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Segment Reporting (Tables) | 9 Months Ended
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Sep. 30, 2025
Segment Reporting [Abstract] |
Schedule of Segment Reporting Presents Reportable Segment Profit and Loss | The following table presents reportable segment profit and loss, including significant expense categories, attributable to the Company’s reportable segment for the periods presented:
| Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
| 2025 |  | 2024 |  |  | 2025 |  | 2024 |
Revenue | $ | 2,764 |  | $ | 3,741 |  |  | $ | 36,341 |  | $ | 39,678 |
Less: |  |  |  |  |  |  |  |  |
Research and development expenses |  |  |  |  |  |  |  |  |
External research and development: |  |  |  |  |  |  |  |  |
STAT6 |  | 17,353 |  |  | 9,078 |  |  |  | 60,151 |  |  | 24,704 |
Other external research and development expense (1) |  | 21,950 |  |  | 22,699 |  |  |  | 71,634 |  |  | 58,377 |
Research and development compensation and related personnel expense (2) |  | 22,323 |  |  | 18,549 |  |  |  | 66,330 |  |  | 56,266 |
Research and development overhead and administrative costs |  | 12,468 |  |  | 10,084 |  |  |  | 34,622 |  |  | 29,084 |
General & administrative (3) |  | 17,336 |  |  | 15,455 |  |  |  | 51,252 |  |  | 47,202 |
Interest and other expense (4) |  | 3,953 |  |  | 60 |  |  |  | 4,135 |  |  | 5,115 |
Plus: |  |  |  |  |  |  |  |  |
Interest income |  | 10,444 |  |  | 9,697 |  |  |  | 27,413 |  |  | 27,964 |
Segment net loss | $ | (82,175 | ) | $ | (62,487 | ) |  | $ | (224,370 | ) | $ | (153,106 | )
(1) Certain prior period amounts have been recast to conform with current period presentation. (2) Research and development compensation and related personnel expense for the three months ended September 30, 2025 and 2024 is inclusive of $8.4 and $7.6 million of stock-based compensation expense, respectively. Research and development compensation and related personnel expense for the nine months ended September 30, 2025 and 2024 is inclusive of $23.9 and $20.9 million of stock-based compensation expense, respectively. (3) General and administrative expense for the three months ended September 30, 2025 and 2024 is inclusive of $7.4 million and $7.3 million of stock-based compensation expense, respectively. General and administrative expense for the nine months ended September 30, 2025 and 2024 is inclusive of $21.5 million and $20.3 million of stock-based compensation expense, respectively. (4) Other expense for the three and nine months ended September 30, 2025 is inclusive of a $3.9 million impairment of long-lived assets. Other expense for the nine months ended September 30, 2024 is inclusive of a $4.9 million impairment of long-lived assets

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- Definition Tabular disclosure of the profit or loss and total assets for each reportable segment. An entity discloses certain information on each reportable segment if the amounts (a) are included in the measure of segment profit or loss reviewed by the chief operating decision maker or (b) are otherwise regularly provided to the chief operating decision maker, even if not included in that measure of segment profit or loss. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 25 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-25 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 22 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-22 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 30 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-30 + Details
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