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v3.25.4

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2025 | Dec. 31, 2024 | Dec. 31, 2023
Cash flows from operating activities |  |  |
Net loss | $ (465,317) | $ (298,408) | $ (214,529)
Reconciliation of net loss to net cash used in operating activities: |  |  |
Stock-based compensation | 91,024 | 69,386 | 40,937
Depreciation and amortization | 3,890 | 2,785 | 1,098
Noncash lease expense | 3,014 | 3,042 | 1,210
Accretion of purchase discounts and amortization of premiums on investment securities, net | (15,425) | (14,931) | (6,271)
Accretion of purchase discounts and amortization of premiums on investment securities, net | 0 | 0 | (2,000)
Loss on equity method investment | 0 | 470 | 5,198
Loss on disposal of property and equipment | 50 | 51 | 6
Changes in operating assets and liabilities: |  |  |
Trade accounts receivable | (592) | 0 | 0
Inventory | (2,022) | 0 | 0
Prepaid expenses and other assets | (16,511) | (5,974) | (4,523)
Accounts payable and accrued expenses, compensation and related expenses, and other non-current liabilities | 28,983 | 13,317 | 12,357
Deferred revenue | (1,835) | 74 | (1,535)
Operating lease liabilities | (3,181) | (6) | (546)
Net cash used in operating activities | (377,922) | (230,194) | (168,598)
CASH FLOWS FROM Investing activities |  |  |
Purchases of investment securities | (1,004,427) | (1,146,772) | (527,857)
Purchase of Radionetics preferred stock | 0 | 0 | (5,000)
Maturities and sale of investment securities | 1,184,097 | 575,799 | 337,132
Purchases of property and equipment | (5,762) | (3,844) | (4,688)
Net cash provided by (used in) investing activities | 173,908 | (574,817) | (200,413)
CASH FLOWS FROM Financing activities |  |  |
Proceeds from issuance of common stock, net of commissions | 0 | 985,030 | 369,560
Offering costs related to issuance of common stock | 0 | (14,982) | (541)
Proceeds from exercise of stock options and shares issued under Employee Stock Purchase Plan | 40,611 | 44,611 | 22,216
Net cash provided by financing activities | 40,611 | 1,014,659 | 391,235
Net change in cash, cash equivalents and restricted cash | (163,403) | 209,648 | 22,224
Exchange rate changes on cash, cash equivalents and restricted cash | (106) | 0 | 0
Cash, cash equivalents and restricted cash - beginning of period | 265,845 | 56,197 | 33,973
Cash, cash equivalents and restricted cash - end of period | 102,336 | 265,845 | 56,197
Components of cash, cash equivalents and restricted cash: |  |  |
Cash and cash equivalents | 101,536 | 264,545 | 54,897
Restricted cash | 800 | 1,300 | 1,300
Cash, cash equivalents and restricted cash at end of period | 102,336 | 265,845 | 56,197
Non-cash investing and financing activities |  |  |
Private company shares received under licensing arrangements | 0 | 0 | 2,000
Exercise of Radionetics Warrant | 0 | 0 | 668
Stock options exercised receivable | 10 | 76 | 166
Receivable for common stock issuances | 0 | 0 | 87
Accrued financing costs | 0 | 0 | 26
Stock held in trust | 112 | 0 | 0
Amounts accrued for purchases of property and equipment | 389 | 180 | 872
Right-of-use asset obtained in exchange for lease obligations | 0 | 0 | 46,273
Leasehold improvements paid by the lessor | $ 0 | $ 0 | $ 2,925

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