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Income Taxes - Additional Information (Details) - USD ($) $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2025 | Dec. 31, 2024
Operating Loss Carryforwards [Line Items] |  |
Federal operating loss carryforwards | $ 861,800 |
State operating loss carryforwards | 258,100 |
Foreign operating loss carryforwards | 14,200 |
Research and development credit carryforwards | $ 79,999 | $ 57,901
Cumulative change in ownership percentage | 50.00% |
United States |  |
Operating Loss Carryforwards [Line Items] |  |
Operating loss carryforward indefinitely | $ 855,400 |
Operating loss carryforwards, future taxable income, offset percentage | 80.00% |
Research and development credit carryforwards | $ 42,400 |
United States | Orphan Drug Credits |  |
Operating Loss Carryforwards [Line Items] |  |
Research and development credit carryforwards | 34,500 |
State |  |
Operating Loss Carryforwards [Line Items] |  |
Operating loss carryforward indefinitely | 5,100 |
California |  |
Operating Loss Carryforwards [Line Items] |  |
Research and development credit carryforwards | 21,500 |
Foreign Tax Jurisdiction |  |
Operating Loss Carryforwards [Line Items] |  |
Operating loss carryforward subject to expiration | $ 10,100 |

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