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Equity Incentive Plans (Tables)

12 Months Ended

Dec. 31, 2025

Share-Based Payment Arrangement [Abstract]

Summary of Activity Under Stock Option Plans

Activity under the Company’s stock option plans during the year ended December 31, 2025 was as follows:

			Options Outstanding						Weighted- Average Exercise Price						Weighted- Average Remaining Term (in years)						Aggregate Intrinsic Value (000’s)
Balance on December 31, 2024			13,665,771						$	26.57
Granted			3,038,153						$	35.85
Exercised			(2,027,378)						$	17.46
Forfeited and expired			(1,045,472)						$	33.27
Balance on December 31, 2025			13,631,074						$	29.54					7.2						$	237,015
Exercisable on December 31, 2025			7,695,416						$	25.28					6.3						$	165,272

Summary of Company's restricted stock unit activity

The Company’s restricted stock unit activity during the year ended December 31, 2025 was as follows:

			Restricted Stock Units Outstanding						Weighted- Average Grant Date Fair Value
Balance on December 31, 2024			1,334,635						$	34.30
Granted			1,624,023						$	35.43
Vested			(415,264)						$	32.51
Forfeited			(221,662)						$	36.19
Balance on December 31, 2025			2,321,732						$	35.23

Weighted Average Assumptions Used to Estimate Fair Value of Stock Options Granted to Employees

The following table summarizes the weighted average assumptions used to estimate the fair value of stock options granted under the Company’s stock option plans for the periods presented below:

Stock Option Awards			Year ended December 31,
			2025						2024						2023
Expected option term			6.0 years						6.0 years						6.0 years
Expected volatility			64		%				66		%				66		%
Risk free interest rate			4.3		%				4.2		%				4.1		%
Expected dividend yield			—		%				—		%				—		%

The following table summarizes the weighted average assumptions used to estimate the fair value of the ESPP awards for the periods presented below:

ESPP			Year ended December 31,
			2025						2024						2023
Expected term			1.3 years						1.3 years						1.1 years
Expected volatility			57		%				72		%				66		%
Risk free interest rate			3.8		%				5.0		%				5.0		%
Expected dividend yield			—		%				—		%				—		%

Summary of Stock-based Compensation Expense for the Equity Awards Issued to Employees and Non-Employees

Stock-based compensation expense for the equity awards issued by the Company to employees and non-employees for the periods presented below was as follows:

			Year ended December 31,
			2025						2024						2023
Included in research and development			$	50,344					$	40,667					$	22,633
Included in general and administrative			40,680						28,719						18,304
Total stock-based compensation expense			$	91,024					$	69,386					$	40,937

Schedule of Unrecognized Tax Benefits

A summary of the Company's total unrecognized stock-based compensation expense, as of December 31, 2025, is as follows:

			Unrecognized Stock-Based Compensation Expense (in thousands)						Average Remaining Vesting Period (in years)
Stock option awards			$	122,413					2.4
RSU awards			$	61,297					2.7
ESPP			$	6,600					1.4

Changes to the Company’s unrecognized tax benefits are summarized in the following table:

			Year ended December 31,
			2025						2024						2023
Beginning balance			$	10,689					$	6,946					$	4,110
Increase (decrease) for prior year tax positions			(20)						(85)						188
Increase (decrease) for current year tax positions			4,083						3,828						2,648
Decreases due to settlements			—						—						—
Expiration of the statute of limitations for the assessment of taxes			—						—						—
Ending balance			$	14,752					$	10,689					$	6,946

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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