XML 50 R34.htm IDEA: XBRL DOCUMENT v3.25.4

Segment Reporting (Tables)

12 Months Ended

Dec. 31, 2025

Segment Reporting [Abstract]

Schedule of Reconciled Consolidated Net Loss

Segment revenue and significant segment expenses which are regularly reported to the CODM are included within the table below and are reconciled to consolidated net loss:

			Year ended December 31,
			2025						2024						2023
Revenue:
Product revenue, net			$	5,420					$	—					$	—
Collaboration and license revenue			2,276						1,039						4,013
Total revenue, net			7,696						1,039						4,013
Less:
Cost of product revenue			(1,076)						—						—
Research and development expenses
Paltusotine			(68,337)						(51,229)						(46,772)
Atumelnant			(48,131)						(24,524)						(13,118)
Other research and development programs			(33,322)						(26,010)						(20,421)
Research and development personnel expenses			(102,677)						(70,772)						(53,446)
Research and development stock-based compensation			(50,344)						(40,667)						(22,633)
Other research and development (1)			(29,247)						(26,954)						(12,137)
Total research and development expenses			(332,058)						(240,156)						(168,527)
Selling, general and administrative
External selling, general and administrative expenses			(90,013)						(38,733)						(20,362)
Selling, general and administrative personnel expenses			(60,638)						(32,285)						(19,428)
Selling, general and administrative stock-based compensation			(40,680)						(28,719)						(18,304)
Total selling, general and administrative expenses			(191,331)						(99,737)						(58,094)
Total other income, net			51,632						40,916						13,277
Income tax expense			(180)						—						—
Loss on equity method investment			—						(470)						(5,198)
Segment and consolidated net loss			$	(465,317)					$	(298,408)					$	(214,529)

(1)Other research and development is comprised of non-personnel related research and development indirect costs incurred for the benefit of multiple research and development programs, including depreciation, and other facility-based expenses, such as rent expense.

X

- Definition

Tabular disclosure of the profit or loss and total assets for each reportable segment. An entity discloses certain information on each reportable segment if the amounts (a) are included in the measure of segment profit or loss reviewed by the chief operating decision maker or (b) are otherwise regularly provided to the chief operating decision maker, even if not included in that measure of segment profit or loss.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 25
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482810/280-10-50-25

Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 22
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482810/280-10-50-22

Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef
-Name Accounting Standards Codification
-Topic 280
-SubTopic 10
-Section 50
-Paragraph 30
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482810/280-10-50-30

+ Details

Name:	us-gaap_ScheduleOfSegmentReportingInformationBySegmentTextBlock
Namespace Prefix:	us-gaap_
Data Type:	dtr-types:textBlockItemType
Balance Type:	na
Period Type:	duration

X

- References

No definition available.

+ Details

Name:	us-gaap_SegmentReportingAbstract
Namespace Prefix:	us-gaap_
Data Type:	xbrli:stringItemType
Balance Type:	na
Period Type:	duration