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Consolidated Statements of Stockholders’ Equity - USD ($)
$ in Thousands
Total
Common Stock Shares
Common Stock and Paid-In Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Stock Held in Trust
Beginning balance (in shares) at Dec. 31, 2022   53,877,000        
Beginning balance at Dec. 31, 2022 $ 316,328   $ 759,432 $ (3,931) $ (439,173) $ 0
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Issuance of common stock, net of transaction costs (in shares)   12,787,000        
Issuance of common stock, net of transaction costs 369,080   369,080      
Exercise of stock options (in shares)   1,283,000        
Exercise of stock options 20,091   20,091      
Stock issued under Employee Stock Purchase Plan (in shares)   147,000        
Stock issued under Employee Stock Purchase Plan 2,291   2,291      
Issuance of common stock upon vesting of restricted stock units (in shares)   81,000        
Stock-based compensation 40,937   40,937      
Comprehensive income (loss) 4,908     4,908    
Net loss (214,529)       (214,529)  
Ending balance (in shares) at Dec. 31, 2023   68,175,000        
Ending balance at Dec. 31, 2023 539,106   1,191,831 977 (653,702) 0
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Issuance of common stock, net of transaction costs (in shares)   21,986,000        
Issuance of common stock, net of transaction costs 970,048   970,048      
Exercise of stock options (in shares)   2,294,000        
Exercise of stock options 40,463   40,463      
Stock issued under Employee Stock Purchase Plan (in shares)   222,000        
Stock issued under Employee Stock Purchase Plan 4,224   4,224      
Issuance of common stock upon vesting of restricted stock units (in shares)   249,000        
Stock-based compensation 69,386   69,386      
Comprehensive income (loss) (14)     (14)    
Net loss (298,408)       (298,408)  
Ending balance (in shares) at Dec. 31, 2024   92,926,000        
Ending balance at Dec. 31, 2024 $ 1,324,805   2,275,952 963 (952,110) 0
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Exercise of stock options (in shares) 2,027,378 2,028,000        
Exercise of stock options $ 35,402   35,402      
Stock issued under Employee Stock Purchase Plan (in shares)   206,000        
Stock issued under Employee Stock Purchase Plan 5,219   5,219      
Issuance of common stock upon vesting of restricted stock units (in shares)   415,000        
Stock-based compensation 91,024   91,024      
Stock held in trust under deferred compensation plan 0   112     (112)
Other 48   48      
Comprehensive income (loss) 902     902    
Net loss (465,317)       (465,317)  
Ending balance (in shares) at Dec. 31, 2025   95,575,000        
Ending balance at Dec. 31, 2025 $ 992,083   $ 2,407,757 $ 1,865 $ (1,417,427) $ (112)