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Income Taxes - Additional Information (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2025
Dec. 31, 2024
Operating Loss Carryforwards [Line Items]    
Federal operating loss carryforwards $ 861,800  
State operating loss carryforwards 258,100  
Foreign operating loss carryforwards 14,200  
Research and development credit carryforwards $ 79,999 $ 57,901
Cumulative change in ownership percentage 50.00%  
United States    
Operating Loss Carryforwards [Line Items]    
Operating loss carryforward indefinitely $ 855,400  
Operating loss carryforwards, future taxable income, offset percentage 80.00%  
Research and development credit carryforwards $ 42,400  
United States | Orphan Drug Credits    
Operating Loss Carryforwards [Line Items]    
Research and development credit carryforwards 34,500  
State    
Operating Loss Carryforwards [Line Items]    
Operating loss carryforward indefinitely 5,100  
California    
Operating Loss Carryforwards [Line Items]    
Research and development credit carryforwards 21,500  
Foreign Tax Jurisdiction    
Operating Loss Carryforwards [Line Items]    
Operating loss carryforward subject to expiration $ 10,100