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Segment Reporting - Schedule of Segment Revenue Reconciled to Consolidated Net Loss (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Segment Reporting Information [Line Items]
Revenue:	$ 7,696	$ 1,039	$ 4,013
Less:
Cost of product revenue	(1,076)	0	0
Selling, general and administrative
Selling, general and administrative	(191,331)	(99,737)	(58,094)
Research and development expenses
Total research and development expenses	(332,058)	(240,156)	(168,527)
Total other income, net	51,632	40,916	13,277
Income tax expense	(180)	0	0
Loss on equity method investment	0	(470)	(5,198)
Net loss	(465,317)	(298,408)	(214,529)
Product revenue, net
Segment Reporting Information [Line Items]
Revenue:	5,420	0	0
Collaboration and license revenue
Segment Reporting Information [Line Items]
Revenue:	2,276	1,039	4,013
Reportable Segment
Segment Reporting Information [Line Items]
Revenue:	7,696	1,039	4,013
Less:
Cost of product revenue	(1,076)	0	0
Selling, general and administrative
External selling, general and administrative expenses	(90,013)	(38,733)	(20,362)
Selling, general and administrative personnel expenses	(60,638)	(32,285)	(19,428)
Selling, general and administrative stock-based compensation	(40,680)	(28,719)	(18,304)
Selling, general and administrative	(191,331)	(99,737)	(58,094)
Research and development expenses
Paltusotine	(68,337)	(51,229)	(46,772)
Atumelnant	(48,131)	(24,524)	(13,118)
Other research and development programs	(33,322)	(26,010)	(20,421)
Research and development personnel expenses	(102,677)	(70,772)	(53,446)
Research and development stock-based compensation	(50,344)	(40,667)	(22,633)
Other research and development	(29,247)	(26,954)	(12,137)
Total research and development expenses	(332,058)	(240,156)	(168,527)
Total other income, net	51,632	40,916	13,277
Income tax expense	(180)	0	0
Loss on equity method investment	0	(470)	(5,198)
Net loss	(465,317)	(298,408)	(214,529)
Reportable Segment | Product revenue, net
Segment Reporting Information [Line Items]
Revenue:	5,420	0	0
Reportable Segment | Collaboration and license revenue
Segment Reporting Information [Line Items]
Revenue:	$ 2,276	$ 1,039	$ 4,013

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