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Condensed Consolidated Statements of Cash Flows - USD ($)
 9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
CASH FLOWS FROM OPERATING ACTIVITIES    
Net loss $ (25,929,000) $ (9,365,000)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 242,000 160,000
Loss on disposal of property and equipment 34,000  
Amortization of premium on available-for-sale securities 82,000  
Stock-based compensation 610,000 62,000
Change in fair value associated with redeemable convertible preferred stock tranche liability 4,194,000 233,000
Change in fair value of redeemable convertible preferred stock warrant liability 525,000 (659,000)
Changes in operating assets and liabilities:    
Research and development tax incentive receivable (1,229,000) (278,000)
Prepaid expenses and other current assets (179,000) (414,000)
Other assets (4,000)  
Accounts payable 157,000 431,000
Accrued expenses and other payables 1,205,000 184,000
Net cash used in operating activities (20,292,000) (9,646,000)
CASH FLOWS FROM INVESTING ACTIVITIES    
Purchase of property and equipment (327,000) (179,000)
Purchase of available-for-sale securities (6,396,000)  
Proceeds from maturities of available-for-sale securities 11,688,000  
Proceeds from sale of property and equipment 32,000  
Net cash provided by (used in) investing activities 4,997,000 (179,000)
CASH FLOWS FROM FINANCING ACTIVITIES    
Proceeds from issuance of redeemable convertible preferred stock, net of issuance costs 22,508,000 17,362,000
Proceeds from issuance of common stock upon exercise of stock options 143,000 57,000
Proceeds from issuance of initial public offering, net of issuance cost 84,508,000  
Net cash provided by financing activities 107,159,000 17,419,000
Effect on exchange rate changes on cash and cash equivalents 105,000 (206,000)
Net increase in cash and cash equivalents 91,969,000 7,388,000
Cash and cash equivalents, beginning of period 4,055,000 9,324,000
Cash and cash equivalents, end of period 96,024,000 16,712,000
SUPPLEMENTAL DISCLOSURES OF NON-CASH FINANCING INFORMATION    
Settlement of fair value of redeemable convertible preferred stock liability 5,837,000  
Tranche liability in connection with the Series C redeemable convertible preferred stock financing   1,017,000
Accretion of redeemable convertible preferred stock 558,000 $ 36,000
Conversion of redeemable convertible preferred stock to common stock at closing of initial public offering 66,904,000  
Offering costs in accounts payable and accrued liabilities 860,000  
Reclassification of preferred stock warrant liability to equity $ 1,005,000