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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
CASH FLOWS FROM OPERATING ACTITIVIES |  |  |
Net loss | $ (37,177) | $ (14,858) | $ (11,072)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 317 | 247 | 258
Loss on disposal of property and equipment | 34 |  |
Amortization of premium on available-for-sale securities | 117 | (8) |
Stock-based compensation | 2,130 | 99 | 42
Change in fair value associated with redeemable convertible preferred stock tranche liability | 4,194 | 626 | 897
Change in fair value of redeemable convertible preferred stock warrant liability | 525 | (543) | 872
Changes in operating assets and liabilities: |  |  |
Research and development tax credit receivable | (1,588) | (192) | 259
Prepaid expenses and other current assets | (1,800) | (1,502) | 604
Other assets | (4) | (30) |
Accounts payable | (115) | 898 | 179
Accrued expenses and other payables | 3,395 | 878 | 218
Net cash used in operating activities | (29,972) | (14,385) | (7,743)
CASH FLOWS FROM INVESTING ACTIVITIES |  |  |
Purchase of available-for-sale securities | (73,169) | (7,865) |
Purchase of property and equipment | (379) | (399) | (299)
Proceeds from maturities of available-for-sale securities | 14,188 |  |
Proceeds from sale of property and equipment | 32 |  |
Net cash used in investing activities | (59,328) | (8,264) | (299)
CASH FLOWS FROM FINANCING ACTIVITIES |  |  |
Proceeds from issuance of redeemable convertible preferred stock, net of issuance costs | 22,488 | 17,362 | 9,000
Proceeds from issuance of redeemable convertible preferred stock upon exercise of preferred stock warrant liability | 20 |  |
Proceeds from issuance of common stock upon exercise of stock options | 151 | 57 | 3
Proceeds from issuance of common stock upon initial public offering, net of issuance costs | 83,648 |  |
Net cash provided by financing activities | 106,307 | 17,419 | 9,003
Effect on exchange rate changes on cash and cash equivalents | 22 | (39) | (97)
Net increase (decrease) in cash and cash equivalents | 17,029 | (5,269) | 864
Cash and cash equivalents, beginning of year | 4,055 | 9,324 | 8,460
Cash and cash equivalents, end of year | 21,084 | 4,055 | 9,324
SUPPLEMENTAL DISCLOSURES OF NON-CASH FINANCING INFORMATION: |  |  |
Settlement of fair value of redeemable convertible preferred stock liability | 5,837 |  | 2,308
Tranche liability in connection with the Series C redeemable convertible preferred stock financing |  | 1,017 |
Accretion of redeemable convertible preferred stock | 558 | $ 75 | $ 146
Conversion of redeemable convertible preferred stock to common stock at closing of initial public offering | 66,904 |  |
Reclassification of preferred stock warrant liability to equity | 1,005 |  |
Purchase of property and equipment in accounts payable | $ 21 |  |

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- Definition The cash inflow associated with the sale or maturity (principal being due) of securities not classified as either held-to-maturity securities or trading securities which are classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=66010992&loc=d3e26853-111562 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The cash inflow associated with the amount received from holders exercising their stock options. This item inherently excludes any excess tax benefit, which the entity may have realized and reported separately. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (j) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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- Definition Value of accretion of temporary equity to its redemption value during the period. + References No definition available. + Details
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