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Consolidated Statements of Operations - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Operating expenses: |  |  |
Research and development | $ 25,705 | $ 11,831 | $ 7,459
General and administrative | 6,961 | 2,963 | 1,860
Total operating expenses | 32,666 | 14,794 | 9,319
Loss from operations | (32,666) | (14,794) | (9,319)
Interest income | 242 | 19 | 16
Change in fair value of redeemable convertible preferred stock tranche and warrant liabilities | (4,719) | (83) | (1,769)
Other expense | (34) |  |
Net loss | (37,177) | (14,858) | (11,072)
Net loss attributable to common stockholders | $ (37,735) | $ (14,933) | $ (11,218)
Net loss per share attributable to common stockholders, basic and diluted | $ (5.80) | $ (59.32) | $ (49.38)
Weighted-average shares used to compute net loss per share attributable to common stockholders, basic and diluted | 6,501,796 | 251,717 | 227,197

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