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Consolidated Statements of Operations - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Operating expenses:      
Research and development $ 25,705 $ 11,831 $ 7,459
General and administrative 6,961 2,963 1,860
Total operating expenses 32,666 14,794 9,319
Loss from operations (32,666) (14,794) (9,319)
Interest income 242 19 16
Change in fair value of redeemable convertible preferred stock tranche and warrant liabilities (4,719) (83) (1,769)
Other expense (34)    
Net loss (37,177) (14,858) (11,072)
Net loss attributable to common stockholders $ (37,735) $ (14,933) $ (11,218)
Net loss per share attributable to common stockholders, basic and diluted $ (5.80) $ (59.32) $ (49.38)
Weighted-average shares used to compute net loss per share attributable to common stockholders, basic and diluted 6,501,796 251,717 227,197