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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
CASH FLOWS FROM OPERATING ACTITIVIES      
Net loss $ (37,177) $ (14,858) $ (11,072)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation and amortization 317 247 258
Loss on disposal of property and equipment 34    
Amortization of premium on available-for-sale securities 117 (8)  
Stock-based compensation 2,130 99 42
Change in fair value associated with redeemable convertible preferred stock tranche liability 4,194 626 897
Change in fair value of redeemable convertible preferred stock warrant liability 525 (543) 872
Changes in operating assets and liabilities:      
Research and development tax credit receivable (1,588) (192) 259
Prepaid expenses and other current assets (1,800) (1,502) 604
Other assets (4) (30)  
Accounts payable (115) 898 179
Accrued expenses and other payables 3,395 878 218
Net cash used in operating activities (29,972) (14,385) (7,743)
CASH FLOWS FROM INVESTING ACTIVITIES      
Purchase of available-for-sale securities (73,169) (7,865)  
Purchase of property and equipment (379) (399) (299)
Proceeds from maturities of available-for-sale securities 14,188    
Proceeds from sale of property and equipment 32    
Net cash used in investing activities (59,328) (8,264) (299)
CASH FLOWS FROM FINANCING ACTIVITIES      
Proceeds from issuance of redeemable convertible preferred stock, net of issuance costs 22,488 17,362 9,000
Proceeds from issuance of redeemable convertible preferred stock upon exercise of preferred stock warrant liability 20    
Proceeds from issuance of common stock upon exercise of stock options 151 57 3
Proceeds from issuance of common stock upon initial public offering, net of issuance costs 83,648    
Net cash provided by financing activities 106,307 17,419 9,003
Effect on exchange rate changes on cash and cash equivalents 22 (39) (97)
Net increase (decrease) in cash and cash equivalents 17,029 (5,269) 864
Cash and cash equivalents, beginning of year 4,055 9,324 8,460
Cash and cash equivalents, end of year 21,084 4,055 9,324
SUPPLEMENTAL DISCLOSURES OF NON-CASH FINANCING INFORMATION:      
Settlement of fair value of redeemable convertible preferred stock liability 5,837   2,308
Tranche liability in connection with the Series C redeemable convertible preferred stock financing   1,017  
Accretion of redeemable convertible preferred stock 558 $ 75 $ 146
Conversion of redeemable convertible preferred stock to common stock at closing of initial public offering 66,904    
Reclassification of preferred stock warrant liability to equity 1,005    
Purchase of property and equipment in accounts payable $ 21