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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
CASH FLOWS FROM OPERATING ACTIVITIES    
Net loss $ (33,905) $ (25,929)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:    
Depreciation and amortization 289 242
(Gain) loss on disposal of property and equipment (62) 34
Net amortization of premium on available-for-sale securities 497 82
Stock-based compensation 3,052 610
Change in fair value associated with redeemable convertible preferred stock tranche liability 0 4,194
Change in fair value of redeemable convertible preferred stock warrant liability 0 525
Changes in operating assets and liabilities:    
Research and development tax incentive receivable 1,530 (1,229)
Receivable from collaboration partner - related party 520 0
Prepaid expenses and other assets 1,034 (183)
Accounts payable 1,096 157
Accrued expenses and other payables 3,271 1,205
Deferred revenue - related party 41,739 0
Net cash provided by (used in) operating activities 18,021 (20,292)
CASH FLOWS FROM INVESTING ACTIVITIES    
Purchase of property and equipment, net (610) (295)
Purchase of available-for-sale securities (28,154) (6,396)
Proceeds from maturities of available-for-sale securities 39,835 11,688
Net cash provided by investing activities 11,071 4,997
CASH FLOWS FROM FINANCING ACTIVITIES    
Proceeds from issuance of redeemable preferred stock, net of issuance costs 0 22,508
Proceeds from issuance of common stock upon exercise of stock options and purchases under employee stock purchase plan 789 143
Payment of deferred offering costs (297) 0
Proceeds from issuance of initial public offering, net of issuance cost 0 84,508
Net cash provided by financing activities 492 107,159
Effect of exchange rate changes on cash, cash equivalents and restricted cash 177 105
Net increase in cash, cash equivalents and restricted cash 29,761 91,969
Cash, cash equivalents and restricted cash, beginning of period 21,094 4,065
Cash, cash equivalents and restricted cash, end of period 50,855 96,034
SUPPLEMENTAL NON-CASH FINANCING AND INVESTING ACTIVITIES    
Conversion of redeemable convertible preferred stock to common stock at closing of initial public offering 0 66,904
Settlement of fair value of redeemable convertible preferred stock liability 0 5,837
Accretion of redeemable convertible preferred stock 0 558
Deferred offering costs in accounts payable and accrued liabilities 0 860
Acquisition of equipment in trade-in 185 0
Purchase of property and equipment in accounts payable and accrued liabilities 6 0
Reclassification of preferred stock warrant liability to equity $ 0 $ 1,005