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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2020 | Mar. 31, 2019
CASH FLOWS FROM OPERATING ACTIVITIES |  |
Net loss | $ (20,080) | $ (14,103)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Stock-based compensation | 2,048 | 1,979
Operating lease right-of-use asset amortization | 444 | 459
Depreciation and amortization | 217 | 130
Amortization of debt issuance costs and accretion of debt discount | 45 |
Accretion of discount on marketable securities, net of premium amortization | (164) | (94)
Foreign currency remeasurement loss | 549 |
Change in deferred tax asset | 183 | 180
Changes in operating assets and liabilities: |  |
Research and development tax incentive receivable | (162) | (441)
Receivable from collaboration partner - related party | 3,161 | (474)
Prepaid expenses and other assets | 806 | (406)
Accounts payable | 913 | 696
Payable to collaboration partner - related party | (146) | 150
Accrued expenses and other payables | (700) | (3,053)
Deferred revenue - related party | (2,485) | (1,222)
Operating lease liability | (477) | (463)
Net cash used in operating activities | (15,848) | (16,662)
CASH FLOWS FROM INVESTING ACTIVITIES |  |
Purchase of marketable securities | (20,883) | (21,726)
Proceeds from maturities of marketable securities | 63,751 | 26,000
Purchases of property and equipment | (138) | (166)
Net cash provided by investing activities | 42,730 | 4,108
CASH FLOWS FROM FINANCING ACTIVITIES |  |
Issuance costs related to issuance of long-term debt | (7) |
Proceeds from issuance of common stock upon exercise of stock options and purchases under employee stock purchase plan | 406 | 390
Net cash provided by financing activities | 399 | 390
Effect of exchange rate changes on cash, cash equivalents and restricted cash | (72) | 8
Net increase (decrease) in cash, cash equivalents and restricted cash | 27,209 | (12,156)
Cash, cash equivalents and restricted cash, beginning of period | 33,466 | 82,693
Cash, cash equivalents and restricted cash, end of period | 60,675 | 70,537
SUPPLEMENTAL DISCLOSURES OF NON-CASH FINANCING AND INVESTING INFORMATION: |  |
Purchases of property and equipment in accounts payable and accrued liabilities | $ 5 | 649
Tenant improvement allowance reimbursement |  | $ 469

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