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Net Loss per Share - Antidilutive Securities (Details) - shares | 12 Months Ended
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Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Potentially dilutive securities have been excluded from diluted net loss per share calculations |  |  |
Anti-dilutive securities (in shares) | 7,671,110 | 6,750,278 | 6,399,025
Options to purchase common stock |  |  |
Potentially dilutive securities have been excluded from diluted net loss per share calculations |  |  |
Anti-dilutive securities (in shares) | 4,648,120 | 3,681,521 | 3,178,441
Common stock warrants |  |  |
Potentially dilutive securities have been excluded from diluted net loss per share calculations |  |  |
Anti-dilutive securities (in shares) | 2,750,000 | 2,750,000 | 2,750,000
Restricted stock units |  |  |
Potentially dilutive securities have been excluded from diluted net loss per share calculations |  |  |
Anti-dilutive securities (in shares) | 244,545 | 278,482 | 418,450
ESPP rights |  |  |
Potentially dilutive securities have been excluded from diluted net loss per share calculations |  |  |
Anti-dilutive securities (in shares) | 28,445 | 40,275 | 52,134

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- Definition Securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) or earnings per unit (EPU) in the future that were not included in the computation of diluted EPS or EPU because to do so would increase EPS or EPU amounts or decrease loss per share or unit amounts for the period presented. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 260 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257 + Details
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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References No definition available. + Details
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