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Research Collaboration and License Agreement (Details) | 12 Months Ended
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Dec. 31, 2020 USD ($) item | Dec. 31, 2019 USD ($) | Dec. 31, 2018 USD ($)
Research Collaboration and License Agreement |  |  |
Research and Development Expense | $ 74,506,000 | $ 65,003,000 | $ 59,497,000
Research Collaboration and License Agreement |  |  |
Research Collaboration and License Agreement |  |  |
Number of development milestone payments | item | 3 |  |
Aggregate development milestone payment | $ 1,000,000.0 |  |
Research and Development Expense | 0 | $ 0 | $ 500,000
Research Collaboration and License Agreement | Phase 2b | Minimum | Entity Required to Continue to Make Payments |  |  |
Research Collaboration and License Agreement |  |  |
Additional payment obligation to the former collaboration partner | 1,000,000.0 |  |
Research Collaboration and License Agreement | Phase 2b | Maximum | Entity Required to Continue to Make Payments |  |  |
Research Collaboration and License Agreement |  |  |
Additional payment obligation to the former collaboration partner | 3,000,000.0 |  |
Research Collaboration and License Agreement | Phase 3 | Minimum | Entity Required to Continue to Make Payments |  |  |
Research Collaboration and License Agreement |  |  |
Additional payment obligation to the former collaboration partner | 1,500,000 |  |
Research Collaboration and License Agreement | Phase 3 | Maximum | Entity Required to Continue to Make Payments |  |  |
Research Collaboration and License Agreement |  |  |
Additional payment obligation to the former collaboration partner | $ 4,500,000 |  |

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- Definition The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 985 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 + Details
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