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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2020

Income Taxes

Schedule of domestic and foreign components of net loss

The following table presents domestic and foreign components of net loss before income taxes (in thousands):

​	​	​	​	​	​	​	​	​	​
​	​	Year Ended December 31,
​		2020			2019			2018
Domestic	​	$	(71,073)	​	$	(72,271)		$	(37,511)
Foreign	​		6,228	​		(5,607)			(2,212)
Total net loss before taxes	​	$	(64,845)	​	$	(77,878)		$	(39,723)

Schedule of federal, state and foreign of the income tax expense (benefit)

​

​	​	​	​	​	​	​	​	​	​
​	​	Year Ended December 31,
​	​	2020		​	2019		​	2018
Current:	​	​	​	​	​	​	​	​	​
Federal	​	$	—	​	$	—	​	$	—
State	​	​	—	​	​	—	​	​	—
Foreign	​	​	(88)	​	​	84	​	​	—
Total current tax (benefit) expense	​	​	(88)	​	​	84	​	​	—
Deferred:	​	​	​	​	​	​	​	​	​
Federal	​	​	—	​	​	—	​	​	—
State	​	​	—	​	​	—	​	​	—
Foreign	​	​	1,393	​	​	(775)	​	​	(799)
Total deferred tax expense (benefit)	​	​	1,393	​	​	(775)	​	​	(799)
Total income tax expense (benefit)	​	$	1,305	​	$	(691)	​	$	(799)

Schedule of provision differences from federal statutory rate

​

​	​	​	​	​	​	​	​
​	​	Year Ended December 31,
​		2020		2019		2018
Federal statutory income tax rate		21.0	%	21.0	%	21.0	%
State taxes, net of federal benefit		1.9		1.2		7.0
Research and development credits	​	6.5	​	4.3	​	(1.3)	​
Foreign tax rate difference		(0.9)		0.7		0.4
Change in valuation allowance		(34.3)		(23.8)		(22.2)
Other		3.8		(2.5)		(2.9)
Provision (benefit) for income taxes		(2.0)	%	0.9	%	2.0	%

Schedule of components of deferred tax assets

The components of the deferred tax assets are as follows (in thousands):

​	​	​	​	​	​	​
​	​	December 31,
​		2020			2019
Deferred tax assets:	​	​	​		​	​
Net operating loss carryforwards	​	$	50,272	​	$	39,907
Depreciation and amortization	​		1,237	​		318
Accruals/other	​		5,332	​		5,454
Operating lease liability	​	​	1,252	​	​	1,516
Research and development and foreign credits	​		14,856	​		8,038
Total deferred tax assets	​		72,949	​		55,233
Deferred tax liabilities:	​	​	​	​	​	​
Operating right-of-use asset	​	​	(1,040)	​	​	(1,269)
Total deferred tax liabilities	​	​	(1,040)	​	​	(1,269)
Valuation allowance	​		(71,909)	​		(52,531)
Net deferred tax assets	​	$	—	​	$	1,433

​

Schedule of reconciliation of beginning and ending unrecognized tax benefits

A reconciliation of the beginning and ending amount of unrecognized tax benefits is as follows (in thousands):

​	​	​	​	​	​	​	​	​	​
​	​	Year Ended December 31,
​		2020			2019			2018
Balance at beginning of year	​	$	16,631	​	$	9,466		$	5,414
(Decreases) increases based on tax positions related to prior years	​		(3,799)	​		184			108
Increases based on tax positions related to current year	​		7,053	​		6,981			3,944
Balance at end of year	​	$	19,885	​	$	16,631		$	9,466

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Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years.

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

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Tabular disclosure of income before income tax between domestic and foreign jurisdictions.

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Tabular disclosure of the change in unrecognized tax benefits.

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