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Consolidated Statements of Operations - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Consolidated Statements of Operations      
License and collaboration revenue - related party $ 28,628 $ 231 $ 30,925
Operating expenses:      
Research and development 74,506 65,003 59,497
General and administrative 18,638 15,749 13,697
Total operating expenses 93,144 80,752 73,194
Loss from operations (64,516) (80,521) (42,269)
Interest income 900 2,813 2,566
Interest expense (598) (169)  
Loss on early repayment of debt (585)    
Other expense, net (46) (1) (20)
Loss before income tax (expense) benefit (64,845) (77,878) (39,723)
Income tax (expense) benefit (1,305) 691 799
Net loss $ (66,150) $ (77,187) $ (38,924)
Net loss per share, basic and diluted $ (1.92) $ (2.98) $ (1.74)
Weighted-average shares used to compute net loss per share, basic and diluted 34,396,446 25,894,024 22,364,515