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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Common Stock
At-the-market offering
Common Stock
Additional Paid-In Capital
At-the-market offering
Additional Paid-In Capital
Accumulated Other Comprehensive Gain (Loss)
Accumulated Deficit
At-the-market offering
Total
Balance, Beginning at Dec. 31, 2017       $ 222,188 $ (6) $ (101,550)   $ 120,632
Balance, Beginning (in shares) at Dec. 31, 2017   21,088,306            
Increase (Decrease) in Stockholders' Equity                
Issuance of common stock, net of issuance costs     $ 1,508       $ 1,508  
Issuance of common stock, net of issuance costs (in shares) 151,273              
Issuance of common stock and warrants upon private placement, net of issuance costs       21,673       21,673
Issuance of common stock and warrants upon private placement, net of issuance costs (in shares)   2,750,000            
Issuance of common stock upon under equity incentive and employee stock purchase plans       934       934
Issuance of common stock upon under equity incentive and employee stock purchase plans (in shares)   197,640            
Retirement of common stock in exchange for common stock warrant       (6,670)       (6,670)
Retirement of common stock in exchange for common stock warrant (in shares)   (1,000,000)            
Issuance of common stock warrant in exchange for retirement of common stock       6,670       6,670
Stock-based compensation expense       6,919       6,919
Other comprehensive gain (loss)         (227)     (227)
Net loss           (38,924)   (38,924)
Balance, Ending at Dec. 31, 2018       253,222 (233) (140,474)   112,515
Balance, Ending (in shares) at Dec. 31, 2018   23,187,219            
Increase (Decrease) in Stockholders' Equity                
Issuance of common stock, net of issuance costs     34,492       34,492  
Issuance of common stock, net of issuance costs (in shares) 2,846,641              
Issuance of common stock upon under equity incentive and employee stock purchase plans       1,779       1,779
Issuance of common stock upon under equity incentive and employee stock purchase plans (in shares)   583,792            
Issuance of common stock upon exercise of Exchange Warrants (in shares)   599,997            
Stock-based compensation expense       8,353       8,353
Other comprehensive gain (loss)         12     12
Net loss           (77,187)   (77,187)
Balance, Ending at Dec. 31, 2019       297,846 (221) (217,661)   $ 79,964
Balance, Ending (in shares) at Dec. 31, 2019   27,217,649           27,217,649
Increase (Decrease) in Stockholders' Equity                
Issuance of common stock, net of issuance costs     $ 41,871 212,974     $ 41,871 $ 212,974
Issuance of common stock, net of issuance costs (in shares) 2,483,719 13,526,189            
Issuance of common stock upon under equity incentive and employee stock purchase plans       2,799       2,799
Issuance of common stock upon under equity incentive and employee stock purchase plans (in shares)   517,908            
Stock-based compensation expense       7,899       7,899
Other comprehensive gain (loss)         249     249
Net loss           (66,150)   (66,150)
Balance, Ending at Dec. 31, 2020       $ 563,389 $ 28 $ (283,811)   $ 279,606
Balance, Ending (in shares) at Dec. 31, 2020   43,745,465           43,745,465