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License and Collaboration Agreement - Narrative (Details) - USD ($) $ in Millions |  | 3 Months Ended | 9 Months Ended |  |  |  |
--- | --- | --- | --- | --- | --- | --- | ---
Jul. 27, 2021 | Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020 | Jun. 30, 2021 | Mar. 31, 2020 | May 07, 2019 | Jul. 13, 2017
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Recognized revenue from deferred revenue contract liability |  | $ 0.2 | $ 8.5 | $ 1.7 | $ 11.8 |  |  |  |
Janssen | License and Collaboration Agreement |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Increase (decrease) in transaction price |  | 8.0 |  | 8.0 |  |  |  |  |
Revenue recognized |  |  | 12.6 |  | 22.0 |  |  |  |
Janssen | License and Collaboration Agreement | Phase 3 clinical trial for a second-generation compound for any indication |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Milestone payment |  | 115.0 |  | 115.0 |  |  |  |  |
Janssen | License and Collaboration Agreement | Completion of clinical data collection for Phase 1 activities for the first of either PN-232 or PN-235 |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Milestone payment |  | 7.5 |  | 7.5 |  |  |  |  |
Janssen | Original Agreement |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Transaction price |  |  |  |  |  | $ 95.8 |  |  |
Janssen | Original Agreement | License and Collaboration Agreement |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Duration of the parties' research collaboration agreement | 2 years |  |  |  |  |  |  |  |
Janssen | Original Agreement | License and Collaboration Agreement | Three phase 1 studies of second-generation compounds |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Expense obligations eliminated | $ 5.0 |  |  |  |  |  |  |  |
Percentage of development cost eliminated | 50.00% |  |  |  |  |  |  |  |
Janssen | Original Agreement | License and Collaboration Agreement | Phase 2a and 2b costs for PTG-200 |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Development cost payable |  | 100.0 |  | $ 100.0 |  |  |  |  |
Development cost incurred, percentage |  |  |  | 20.00% |  |  |  |  |
Janssen | Original Agreement | License and Collaboration Agreement | Phase 2 studies for second-generation products |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Percentage of development cost eliminated | 20.00% |  |  |  |  |  |  |  |
Milestone payment |  |  |  |  |  |  |  |  | $ 50.0
Janssen | Original Agreement | License and Collaboration Agreement | Maximum | Three phase 1 studies of second-generation compounds |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Development cost payable |  |  |  |  |  |  |  |  | 20.0
Janssen | Original Agreement | License and Collaboration Agreement | Maximum | Phase 2a and 2b costs for PTG-200 |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Development cost payable |  |  |  |  |  |  |  |  | 20.0
Janssen | Original Agreement | License and Collaboration Agreement | Maximum | Phase 2 studies for second-generation products |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Development cost payable |  | 25.0 |  | $ 25.0 |  |  |  |  |
Expense obligations eliminated | $ 25.0 |  |  |  |  |  |  |  |
Janssen | Original Agreement | Upfront cash payment |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Upfront payment |  |  |  |  |  |  |  |  | $ 50.0
Janssen | Restated Agreement |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Upfront payment |  | 80.0 |  | 80.0 |  |  |  |  |
Development cost payable |  | 8.1 |  | 8.1 |  |  |  |  |
Reimbursement for services performed |  | 8.4 |  | 8.4 |  |  |  |  |
Maximum percentages royalties on net product sales | 10.00% |  |  |  |  |  |  |  |
Increase (decrease) in transaction price | $ 8.0 |  |  | 9.9 |  |  |  |  |
Transaction price |  | 105.7 |  | $ 105.7 |  |  |  |  |
Janssen | Restated Agreement | Second-generation Oral Interleukin ("IL")-23 Receptor Antagonist Development Compound |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Eligible amount received |  |  |  |  |  |  | $ 5.0 |  |
Janssen | Restated Agreement | Phase 2a study evaluating PTG-200 for the treatment of CD |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Development cost incurred, percentage |  |  |  | 50.00% |  |  |  |  |
Janssen | Restated Agreement | Services performed for IL-23 receptor antagonist compound research costs and other services |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Reimbursement for services performed |  | 17.9 |  | $ 17.9 |  |  |  |  |
Janssen | Restated Agreement | Additional services |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Revenue recognized |  | 0.0 | $ 0.5 | 0.8 | $ 1.0 |  |  |  |
Janssen | Restated Agreement | License and Collaboration Agreement |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Eligible amount received |  |  |  |  |  |  |  | $ 25.0 |
Collaboration revenue recorded following the contract modification |  | 2.3 |  | $ 9.9 |  |  |  |  |
Janssen | Restated Agreement | License and Collaboration Agreement | Phase 1 studies of second-generation compounds |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Percentage of development cost eliminated |  |  |  | 100.00% |  |  |  |  |
Upcoming potential development milestones |  | 7.5 |  | $ 7.5 |  |  |  |  |
Janssen | Restated Agreement | License and Collaboration Agreement | Phase 2 studies for second-generation products |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Development cost payable |  | 25.0 |  | 25.0 |  |  |  |  |
Milestone payment | $ 25.0 |  |  |  |  |  |  |  |
Janssen | Restated Agreement | License and Collaboration Agreement | 3rd patient in the first Phase 2 clinical trial for any second-generation compound for any indication |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Upcoming potential development milestones |  | 25.0 |  | 25.0 |  |  |  |  |
Janssen | Restated Agreement | License and Collaboration Agreement | 3rd patient in the first Phase 2 clinical trial for any second-generation compound for a second indication |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Upcoming potential development milestones |  | 10.0 |  | $ 10.0 |  |  |  |  |
Janssen | Restated Agreement | License and Collaboration Agreement | Phase 2a study evaluating PTG-200 for the treatment of CD |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Development cost incurred, percentage |  |  |  | 20.00% |  |  |  |  |
Janssen | Restated Agreement | License and Collaboration Agreement | Dosing of the 3rd patient in a Phase 3 clinical trial for a second-generation compound for any indication |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Upcoming potential development milestones |  | 50.0 |  | $ 50.0 |  |  |  |  |
Janssen | Restated Agreement | License and Collaboration Agreement | Dosing Of Third Patient In Phase 3 Clinical Trial For Second Generation Compound For A Second Indication [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Milestone payment |  | 15.0 |  | 15.0 |  |  |  |  |
Janssen | Restated Agreement | License and Collaboration Agreement | Maximum | Phase 2a study evaluating PTG-200 for the treatment of CD |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Development cost payable |  | $ 20.0 |  | $ 20.0 |  |  |  |  |

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