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License and Collaboration Agreement - Narrative (Details) - USD ($)
$ in Millions
3 Months Ended 9 Months Ended
Jul. 27, 2021
Sep. 30, 2021
Sep. 30, 2020
Sep. 30, 2021
Sep. 30, 2020
Jun. 30, 2021
Mar. 31, 2020
May 07, 2019
Jul. 13, 2017
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Recognized revenue from deferred revenue contract liability   $ 0.2 $ 8.5 $ 1.7 $ 11.8        
Janssen | License and Collaboration Agreement                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Increase (decrease) in transaction price   8.0   8.0          
Revenue recognized     12.6   22.0        
Janssen | License and Collaboration Agreement | Phase 3 clinical trial for a second-generation compound for any indication                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Milestone payment   115.0   115.0          
Janssen | License and Collaboration Agreement | Completion of clinical data collection for Phase 1 activities for the first of either PN-232 or PN-235                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Milestone payment   7.5   7.5          
Janssen | Original Agreement                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Transaction price           $ 95.8      
Janssen | Original Agreement | License and Collaboration Agreement                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Duration of the parties' research collaboration agreement 2 years                
Janssen | Original Agreement | License and Collaboration Agreement | Three phase 1 studies of second-generation compounds                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Expense obligations eliminated $ 5.0                
Percentage of development cost eliminated 50.00%                
Janssen | Original Agreement | License and Collaboration Agreement | Phase 2a and 2b costs for PTG-200                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Development cost payable   100.0   $ 100.0          
Development cost incurred, percentage       20.00%          
Janssen | Original Agreement | License and Collaboration Agreement | Phase 2 studies for second-generation products                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Percentage of development cost eliminated 20.00%                
Milestone payment                 $ 50.0
Janssen | Original Agreement | License and Collaboration Agreement | Maximum | Three phase 1 studies of second-generation compounds                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Development cost payable                 20.0
Janssen | Original Agreement | License and Collaboration Agreement | Maximum | Phase 2a and 2b costs for PTG-200                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Development cost payable                 20.0
Janssen | Original Agreement | License and Collaboration Agreement | Maximum | Phase 2 studies for second-generation products                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Development cost payable   25.0   $ 25.0          
Expense obligations eliminated $ 25.0                
Janssen | Original Agreement | Upfront cash payment                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Upfront payment                 $ 50.0
Janssen | Restated Agreement                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Upfront payment   80.0   80.0          
Development cost payable   8.1   8.1          
Reimbursement for services performed   8.4   8.4          
Maximum percentages royalties on net product sales 10.00%                
Increase (decrease) in transaction price $ 8.0     9.9          
Transaction price   105.7   $ 105.7          
Janssen | Restated Agreement | Second-generation Oral Interleukin ("IL")-23 Receptor Antagonist Development Compound                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Eligible amount received             $ 5.0    
Janssen | Restated Agreement | Phase 2a study evaluating PTG-200 for the treatment of CD                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Development cost incurred, percentage       50.00%          
Janssen | Restated Agreement | Services performed for IL-23 receptor antagonist compound research costs and other services                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Reimbursement for services performed   17.9   $ 17.9          
Janssen | Restated Agreement | Additional services                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Revenue recognized   0.0 $ 0.5 0.8 $ 1.0        
Janssen | Restated Agreement | License and Collaboration Agreement                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Eligible amount received               $ 25.0  
Collaboration revenue recorded following the contract modification   2.3   $ 9.9          
Janssen | Restated Agreement | License and Collaboration Agreement | Phase 1 studies of second-generation compounds                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Percentage of development cost eliminated       100.00%          
Upcoming potential development milestones   7.5   $ 7.5          
Janssen | Restated Agreement | License and Collaboration Agreement | Phase 2 studies for second-generation products                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Development cost payable   25.0   25.0          
Milestone payment $ 25.0                
Janssen | Restated Agreement | License and Collaboration Agreement | 3rd patient in the first Phase 2 clinical trial for any second-generation compound for any indication                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Upcoming potential development milestones   25.0   25.0          
Janssen | Restated Agreement | License and Collaboration Agreement | 3rd patient in the first Phase 2 clinical trial for any second-generation compound for a second indication                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Upcoming potential development milestones   10.0   $ 10.0          
Janssen | Restated Agreement | License and Collaboration Agreement | Phase 2a study evaluating PTG-200 for the treatment of CD                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Development cost incurred, percentage       20.00%          
Janssen | Restated Agreement | License and Collaboration Agreement | Dosing of the 3rd patient in a Phase 3 clinical trial for a second-generation compound for any indication                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Upcoming potential development milestones   50.0   $ 50.0          
Janssen | Restated Agreement | License and Collaboration Agreement | Dosing Of Third Patient In Phase 3 Clinical Trial For Second Generation Compound For A Second Indication [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Milestone payment   15.0   15.0          
Janssen | Restated Agreement | License and Collaboration Agreement | Maximum | Phase 2a study evaluating PTG-200 for the treatment of CD                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Development cost payable   $ 20.0   $ 20.0