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v3.22.1

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2022 | Mar. 31, 2021 | Dec. 31, 2020
Cash Flows from Operating Activities |  |  |
Net loss | $ (20,930) | $ (23,998) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Stock-based compensation | 5,935 | 2,660 |
Operating lease right-of-use asset amortization | 584 | 444 |
Net amortization of premium on marketable securities | 358 | 348 |
Depreciation | 249 | 180 |
Changes in operating assets and liabilities: |  |  |
Research and development tax incentive receivable |  | (751) |
Receivable from collaboration partner - related party | (23,584) | (1,570) |
Prepaid expenses and other assets | 1,279 | 57 |
Accounts payable | 5,559 | (344) |
Payable to collaboration partner - related party | (519) | 4,091 |
Accrued expenses and other payables | (5,110) | (673) |
Deferred revenue - related party | (833) | (8,709) |
Operating lease liability | (654) | (491) |
Net cash used in operating activities | (37,666) | (28,756) |
Cash Flows from Investing Activities |  |  |
Purchase of marketable securities | (55,832) | (87,205) |
Proceeds from maturities of marketable securities | 51,629 | 80,552 |
Purchases of property and equipment | (273) | (140) |
Net cash used in investing activities | (4,476) | (6,793) |
Cash Flows from Financing Activities |  |  |
Proceeds from at-the-market offering, net of issuance costs | 14,553 |  |
Proceeds from issuance of common stock upon exercise of stock options and purchases under employee stock purchase plan | 2,558 | 1,316 |
Tax withholding payments related to net settlement of restricted stock units | (186) | (189) |
Issuance costs related to common stock offering |  | (148) |
Net cash provided by financing activities | 16,925 | 979 |
Effect of exchange rate changes on cash, cash equivalents and restricted cash | 29 | (23) |
Net decrease in cash, cash equivalents and restricted cash | (25,188) | (34,593) |
Cash, cash equivalents and restricted cash, beginning of period | 123,890 | 117,818 |
Cash, cash equivalents and restricted cash, end of period | 98,702 | 83,225 | $ 117,818
Supplemental Disclosure of Non-Cash Financing and Investing Information: |  |  |
Purchases of property and equipment in accounts payable and accrued liabilities | 235 | 97 |
Public Offering | Accrued liabilities and other payables |  |  |
Supplemental Disclosure of Non-Cash Financing and Investing Information: |  |  |
Issuance costs related to common stock offering | $ 25 | $ 58 | $ 205

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