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License and Collaboration Agreement - Narrative (Details) - USD ($)
3 Months Ended 12 Months Ended
Jul. 27, 2021
Mar. 31, 2022
Mar. 31, 2021
Dec. 31, 2021
Mar. 31, 2020
May 07, 2019
Jul. 13, 2017
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Recognized revenue from deferred revenue contract liability   $ 13,000 $ 1,100,000        
Janssen | Services performed for IL-23 receptor antagonist compound research costs and other services              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Reimbursement for services performed   17,900,000          
Janssen | License and Collaboration Agreement              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Collaboration revenue recorded following the contract modification   25,700,000 5,600,000        
Janssen | License and Collaboration Agreement | Three phase 1 studies of second-generation compounds              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Eligible amount received       $ 7,500,000      
Janssen | License and Collaboration Agreement | 3rd patient in the first Phase 2 clinical trial for any second-generation compound for a second indication              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Eligible amount received   25,000,000.0          
Janssen | License and Collaboration Agreement | Phase 3 clinical trial for a second-generation compound for any indication              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Upcoming potential development milestones   115,000,000.0          
Janssen | License and Collaboration Agreement | Completion of clinical data collection for Phase 1 activities for the first of either PN-232 or PN-235              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Upcoming potential development milestones   25,000,000.0          
Janssen | Original Agreement              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Transaction price       106,500,000      
Janssen | Original Agreement | License and Collaboration Agreement              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Duration of the parties' research collaboration agreement 2 years            
Janssen | Original Agreement | License and Collaboration Agreement | Three phase 1 studies of second-generation compounds              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Expense obligations eliminated $ 5,000,000.0            
Percentage of development cost eliminated 50.00%            
Janssen | Original Agreement | License and Collaboration Agreement | Phase 2a and 2b costs for PTG-200              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Development cost payable   $ 100,000,000.0          
Development cost incurred, percentage   20.00%          
Janssen | Original Agreement | License and Collaboration Agreement | Phase 2 studies for second-generation products              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Percentage of development cost eliminated 20.00%            
Milestone payment             $ 50,000,000.0
Janssen | Original Agreement | License and Collaboration Agreement | Maximum | Three phase 1 studies of second-generation compounds              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Development cost payable             20,000,000.0
Janssen | Original Agreement | License and Collaboration Agreement | Maximum | Phase 2a and 2b costs for PTG-200              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Development cost payable             20,000,000.0
Janssen | Original Agreement | License and Collaboration Agreement | Maximum | Phase 2 studies for second-generation products              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Development cost payable   $ 25,000,000.0          
Expense obligations eliminated $ 25,000,000.0            
Janssen | Original Agreement | Upfront cash payment              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Upfront payment             $ 50,000,000.0
Janssen | Restated Agreement              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Upfront payment   87,500,000          
Development cost payable   7,100,000          
Reimbursement for services performed   8,200,000          
Maximum percentages royalties on net product sales 10.00%            
Increase (decrease) in transaction price   25,000,000.0   $ 8,000,000.0      
Transaction price   $ 131,500,000          
Janssen | Restated Agreement | Second-generation Oral Interleukin ("IL")-23 Receptor Antagonist Development Compound              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Eligible amount received         $ 5,000,000.0    
Janssen | Restated Agreement | Phase 2a study evaluating PTG-200 for the treatment of CD              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Development cost incurred, percentage   50.00%          
Janssen | Restated Agreement | Additional services              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Revenue recognized   $ 0 $ 600,000        
Janssen | Restated Agreement | License and Collaboration Agreement              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Eligible amount received           $ 25,000,000.0  
Janssen | Restated Agreement | License and Collaboration Agreement | Phase 1 studies of second-generation compounds              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Percentage of development cost eliminated   100.00%          
Janssen | Restated Agreement | License and Collaboration Agreement | Phase 2 studies for second-generation products              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Upcoming potential development milestones   $ 25,000,000.0          
Milestone payment $ 25,000,000.0            
Janssen | Restated Agreement | License and Collaboration Agreement | 3rd patient in the first Phase 2 clinical trial for any second-generation compound for a second indication              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Upcoming potential development milestones   $ 10,000,000.0          
Janssen | Restated Agreement | License and Collaboration Agreement | Phase 2a study evaluating PTG-200 for the treatment of CD              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Development cost incurred, percentage   20.00%          
Janssen | Restated Agreement | License and Collaboration Agreement | Dosing of the 3rd patient in a Phase 3 clinical trial for a second-generation compound for any indication              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Upcoming potential development milestones   $ 50,000,000.0          
Janssen | Restated Agreement | License and Collaboration Agreement | Dosing Of Third Patient In Phase 3 Clinical Trial For Second Generation Compound For A Second Indication [Member]              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Upcoming potential development milestones   15,000,000.0          
Janssen | Restated Agreement | License and Collaboration Agreement | Maximum | Phase 2a study evaluating PTG-200 for the treatment of CD              
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]              
Development cost payable   $ 20,000,000.0