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Equity Plans - Stock-based Compensation Expense (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]    
Total stock-based compensation expense $ 5,935 $ 2,660
Total unrecognized stock-based compensation costs related to stock options $ 73,600  
Period of unrecognized stock-based compensation costs to be recognized 2 years 10 months 24 days  
Research and Development    
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]    
Total stock-based compensation expense $ 3,326 1,475
General and Administrative    
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]    
Total stock-based compensation expense $ 2,609 $ 1,185