<SEC-DOCUMENT>0001623632-22-000230-index.html : 20220214
<SEC-HEADER>0001623632-22-000230.hdr.sgml : 20220214
<ACCEPTANCE-DATETIME>20220214132653
ACCESSION NUMBER:		0001623632-22-000230
CONFORMED SUBMISSION TYPE:	SC 13G
PUBLIC DOCUMENT COUNT:		3
FILED AS OF DATE:		20220214
DATE AS OF CHANGE:		20220214

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Orchard Therapeutics plc
		CENTRAL INDEX KEY:			0001748907
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-90710
		FILM NUMBER:		22628816

	BUSINESS ADDRESS:	
		STREET 1:		108 CANNON STREET
		CITY:			LONDON
		STATE:			X0
		ZIP:			EC4N 6EU
		BUSINESS PHONE:		011-44-0-203-3846700

	MAIL ADDRESS:	
		STREET 1:		108 CANNON STREET
		CITY:			LONDON
		STATE:			X0
		ZIP:			EC4N 6EU

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Orchard Rx Ltd
		DATE OF NAME CHANGE:	20180802

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			FEDERATED HERMES, INC.
		CENTRAL INDEX KEY:			0001056288
		STANDARD INDUSTRIAL CLASSIFICATION:	INVESTMENT ADVICE [6282]
		IRS NUMBER:				251111467
		STATE OF INCORPORATION:			PA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G

	BUSINESS ADDRESS:	
		STREET 1:		1001 LIBERTY AVENUE
		CITY:			PITTSBURGH
		STATE:			PA
		ZIP:			15222
		BUSINESS PHONE:		4122881900

	MAIL ADDRESS:	
		STREET 1:		1001 LIBERTY AVENUE
		CITY:			PITTSBURGH
		STATE:			PA
		ZIP:			15222

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FEDERATED INVESTORS INC /PA/
		DATE OF NAME CHANGE:	20200130

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FEDERATED HERMES, INC.
		DATE OF NAME CHANGE:	20200130

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FEDERATED INVESTORS INC /PA/
		DATE OF NAME CHANGE:	19980219
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G
<SEQUENCE>1
<FILENAME>form45.htm
<TEXT>
Document 1 - file: form45.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>image_001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: image_001.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>image_002.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: image_002.jpg

</DOCUMENT>
</SEC-DOCUMENT>