<SEC-DOCUMENT>0001623632-23-000226-index.html : 20230201
<SEC-HEADER>0001623632-23-000226.hdr.sgml : 20230201
<ACCEPTANCE-DATETIME>20230201112503
ACCESSION NUMBER:		0001623632-23-000226
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20230201
DATE AS OF CHANGE:		20230201

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Orchard Therapeutics plc
		CENTRAL INDEX KEY:			0001748907
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-90710
		FILM NUMBER:		23575430

	BUSINESS ADDRESS:	
		STREET 1:		245 HAMMERSMITH ROAD, 3RD FLOOR
		CITY:			LONDON
		STATE:			X0
		ZIP:			W6 8PW
		BUSINESS PHONE:		011-44-0-203-3846700

	MAIL ADDRESS:	
		STREET 1:		245 HAMMERSMITH ROAD, 3RD FLOOR
		CITY:			LONDON
		STATE:			X0
		ZIP:			W6 8PW

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Orchard Rx Ltd
		DATE OF NAME CHANGE:	20180802

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			FEDERATED HERMES, INC.
		CENTRAL INDEX KEY:			0001056288
		STANDARD INDUSTRIAL CLASSIFICATION:	INVESTMENT ADVICE [6282]
		IRS NUMBER:				251111467
		STATE OF INCORPORATION:			PA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		1001 LIBERTY AVENUE
		CITY:			PITTSBURGH
		STATE:			PA
		ZIP:			15222
		BUSINESS PHONE:		4122881900

	MAIL ADDRESS:	
		STREET 1:		1001 LIBERTY AVENUE
		CITY:			PITTSBURGH
		STATE:			PA
		ZIP:			15222

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FEDERATED INVESTORS INC /PA/
		DATE OF NAME CHANGE:	20200130

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FEDERATED HERMES, INC.
		DATE OF NAME CHANGE:	20200130

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FEDERATED INVESTORS INC /PA/
		DATE OF NAME CHANGE:	19980219
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>form825.htm
<TEXT>
Document 1 - file: form825.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>image_001.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: image_001.jpg

</DOCUMENT>
</SEC-DOCUMENT>