<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2023 Workiva-->
<!--r:65ceb81b-1301-4d03-a3b5-a19a3f419a3b,g:9d9ffaaa-0d49-4a33-8fc4-ed994a16f30c-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.calix.com/role/ConsolidatedStatementsofStockholdersEquity" xlink:type="simple" xlink:href="calx-20221231.xsd#ConsolidatedStatementsofStockholdersEquity"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/ConsolidatedStatementsofStockholdersEquity" xlink:type="extended" id="id2efbd3e5d604164a772f435e674cd10_ConsolidatedStatementsofStockholdersEquity">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_a87d7cbd-3ff4-46ba-b845-68db4df885b8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f03fa36c-bda7-4d2f-9746-baab5f6afbb9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_a87d7cbd-3ff4-46ba-b845-68db4df885b8" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f03fa36c-bda7-4d2f-9746-baab5f6afbb9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_0cb07742-2f1a-4e38-90ab-d542fe21781a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f03fa36c-bda7-4d2f-9746-baab5f6afbb9" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_0cb07742-2f1a-4e38-90ab-d542fe21781a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_f2e9e747-4525-439a-b96c-a07f07d5fb24" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f03fa36c-bda7-4d2f-9746-baab5f6afbb9" xlink:to="loc_us-gaap_StockholdersEquity_f2e9e747-4525-439a-b96c-a07f07d5fb24" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_6b5803ea-34c7-40c6-a1e7-cde14dce4ce1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f03fa36c-bda7-4d2f-9746-baab5f6afbb9" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_6b5803ea-34c7-40c6-a1e7-cde14dce4ce1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_ff7b91e4-0485-4795-a875-09f9773323aa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f03fa36c-bda7-4d2f-9746-baab5f6afbb9" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_ff7b91e4-0485-4795-a875-09f9773323aa" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_36e46b8b-517d-4521-81d9-4c846fc4e9d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f03fa36c-bda7-4d2f-9746-baab5f6afbb9" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_36e46b8b-517d-4521-81d9-4c846fc4e9d1" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_77615cd1-2ce5-4603-af2b-9a7d028188a6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f03fa36c-bda7-4d2f-9746-baab5f6afbb9" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_77615cd1-2ce5-4603-af2b-9a7d028188a6" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_84902d70-5a2f-49d2-8fe8-e8c6a73b6509" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f03fa36c-bda7-4d2f-9746-baab5f6afbb9" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueNewIssues_84902d70-5a2f-49d2-8fe8-e8c6a73b6509" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodValue_0602ef42-8000-4f93-9c70-9f376127c9b0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchasedAndRetiredDuringPeriodValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f03fa36c-bda7-4d2f-9746-baab5f6afbb9" xlink:to="loc_us-gaap_StockRepurchasedAndRetiredDuringPeriodValue_0602ef42-8000-4f93-9c70-9f376127c9b0" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_885ddf07-22e4-4922-bd82-fcafbe1a9584" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f03fa36c-bda7-4d2f-9746-baab5f6afbb9" xlink:to="loc_us-gaap_NetIncomeLoss_885ddf07-22e4-4922-bd82-fcafbe1a9584" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_16cc935c-ff3b-46b6-bfa6-79d559601fd5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_f03fa36c-bda7-4d2f-9746-baab5f6afbb9" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_16cc935c-ff3b-46b6-bfa6-79d559601fd5" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_bf0c9a07-14f8-4ae2-8d57-9be6e1b0b887" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_c4ec5de6-4436-4ae8-8362-7fed28bef5f7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_4268c830-51ff-47cf-b79c-b61b732e49fb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_a87d7cbd-3ff4-46ba-b845-68db4df885b8" xlink:to="loc_us-gaap_StatementTable_4268c830-51ff-47cf-b79c-b61b732e49fb" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_64b8310a-fe67-47da-b001-2302be1089cc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_4268c830-51ff-47cf-b79c-b61b732e49fb" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_64b8310a-fe67-47da-b001-2302be1089cc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_64b8310a-fe67-47da-b001-2302be1089cc_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_64b8310a-fe67-47da-b001-2302be1089cc" xlink:to="loc_us-gaap_EquityComponentDomain_64b8310a-fe67-47da-b001-2302be1089cc_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_40cbe640-ceec-45ef-9dde-0be57332a116" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_64b8310a-fe67-47da-b001-2302be1089cc" xlink:to="loc_us-gaap_EquityComponentDomain_40cbe640-ceec-45ef-9dde-0be57332a116" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_2426cdd9-a245-4638-a263-87817e310412" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_40cbe640-ceec-45ef-9dde-0be57332a116" xlink:to="loc_us-gaap_CommonStockMember_2426cdd9-a245-4638-a263-87817e310412" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_e509c4a3-1b53-4a72-ba62-756f6a221752" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_40cbe640-ceec-45ef-9dde-0be57332a116" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_e509c4a3-1b53-4a72-ba62-756f6a221752" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_05eefd7a-7f9c-4d0f-9325-ed0088e27e20" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_40cbe640-ceec-45ef-9dde-0be57332a116" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_05eefd7a-7f9c-4d0f-9325-ed0088e27e20" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_4944b04f-0b7b-48a9-9df4-e4fd73bd5120" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_40cbe640-ceec-45ef-9dde-0be57332a116" xlink:to="loc_us-gaap_RetainedEarningsMember_4944b04f-0b7b-48a9-9df4-e4fd73bd5120" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonMember_3c6e30cf-6203-4cb4-bbab-92b8b95c3082" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TreasuryStockCommonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_40cbe640-ceec-45ef-9dde-0be57332a116" xlink:to="loc_us-gaap_TreasuryStockCommonMember_3c6e30cf-6203-4cb4-bbab-92b8b95c3082" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/DescriptionofBusinessandSignificantAccountingPoliciesUsefulLivesofPropertyandEquipmentDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#DescriptionofBusinessandSignificantAccountingPoliciesUsefulLivesofPropertyandEquipmentDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/DescriptionofBusinessandSignificantAccountingPoliciesUsefulLivesofPropertyandEquipmentDetails" xlink:type="extended" id="i5550cd74878648f7aedc83d9d1747acb_DescriptionofBusinessandSignificantAccountingPoliciesUsefulLivesofPropertyandEquipmentDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_85bf585f-e8ed-46ce-acd2-9b24daf973d5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_84812ad3-db95-41c7-b3d4-69df8845b489" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_85bf585f-e8ed-46ce-acd2-9b24daf973d5" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_84812ad3-db95-41c7-b3d4-69df8845b489" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_75bdcb4c-9d1e-45eb-8517-46f6a7e2c717" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_85bf585f-e8ed-46ce-acd2-9b24daf973d5" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_75bdcb4c-9d1e-45eb-8517-46f6a7e2c717" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_a8386bdb-989b-4d37-bd74-b1492491ca35" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_75bdcb4c-9d1e-45eb-8517-46f6a7e2c717" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_a8386bdb-989b-4d37-bd74-b1492491ca35" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_a8386bdb-989b-4d37-bd74-b1492491ca35_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_a8386bdb-989b-4d37-bd74-b1492491ca35" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_a8386bdb-989b-4d37-bd74-b1492491ca35_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_76147100-373f-4148-991e-53d163024eaa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_a8386bdb-989b-4d37-bd74-b1492491ca35" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_76147100-373f-4148-991e-53d163024eaa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComputerEquipmentMember_85b21e38-2499-4285-935e-189f4785168c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComputerEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_76147100-373f-4148-991e-53d163024eaa" xlink:to="loc_us-gaap_ComputerEquipmentMember_85b21e38-2499-4285-935e-189f4785168c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComputerSoftwareIntangibleAssetMember_721ec2be-db3a-4011-af7d-6fc95de982ea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComputerSoftwareIntangibleAssetMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_76147100-373f-4148-991e-53d163024eaa" xlink:to="loc_us-gaap_ComputerSoftwareIntangibleAssetMember_721ec2be-db3a-4011-af7d-6fc95de982ea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquipmentMember_ae2a9090-fb4d-4349-88a6-bc4e6787722d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_76147100-373f-4148-991e-53d163024eaa" xlink:to="loc_us-gaap_EquipmentMember_ae2a9090-fb4d-4349-88a6-bc4e6787722d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_9c3977a5-250e-4fad-80a8-5407e9461476" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FurnitureAndFixturesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_76147100-373f-4148-991e-53d163024eaa" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_9c3977a5-250e-4fad-80a8-5407e9461476" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_2c8ab956-5784-4b0e-9dc6-66e3fdc56818" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_75bdcb4c-9d1e-45eb-8517-46f6a7e2c717" xlink:to="loc_srt_RangeAxis_2c8ab956-5784-4b0e-9dc6-66e3fdc56818" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_2c8ab956-5784-4b0e-9dc6-66e3fdc56818_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_2c8ab956-5784-4b0e-9dc6-66e3fdc56818" xlink:to="loc_srt_RangeMember_2c8ab956-5784-4b0e-9dc6-66e3fdc56818_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_e9a96705-45b5-4d17-9847-9330715c8fa5" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_2c8ab956-5784-4b0e-9dc6-66e3fdc56818" xlink:to="loc_srt_RangeMember_e9a96705-45b5-4d17-9847-9330715c8fa5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_056a8ae2-2edc-4850-82b5-d6866d7f88ca" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_e9a96705-45b5-4d17-9847-9330715c8fa5" xlink:to="loc_srt_MinimumMember_056a8ae2-2edc-4850-82b5-d6866d7f88ca" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_affb463d-5f11-4569-8f79-1596fba2661e" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_e9a96705-45b5-4d17-9847-9330715c8fa5" xlink:to="loc_srt_MaximumMember_affb463d-5f11-4569-8f79-1596fba2661e" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/DescriptionofBusinessandSignificantAccountingPoliciesAdditionalInformationDetail" xlink:type="simple" xlink:href="calx-20221231.xsd#DescriptionofBusinessandSignificantAccountingPoliciesAdditionalInformationDetail"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/DescriptionofBusinessandSignificantAccountingPoliciesAdditionalInformationDetail" xlink:type="extended" id="ia57c24facaab445c8f16c9192103f190_DescriptionofBusinessandSignificantAccountingPoliciesAdditionalInformationDetail">
    <link:loc xlink:type="locator" xlink:label="loc_calx_ScheduleOfCertainTermsLineItemsLineItems_19c87865-bb4d-4b19-9ebf-d97c7f658027" xlink:href="calx-20221231.xsd#calx_ScheduleOfCertainTermsLineItemsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_ProductWarrantyPeriod_f4e3c96d-2bbb-4edd-8853-308948497bc6" xlink:href="calx-20221231.xsd#calx_ProductWarrantyPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_calx_ScheduleOfCertainTermsLineItemsLineItems_19c87865-bb4d-4b19-9ebf-d97c7f658027" xlink:to="loc_calx_ProductWarrantyPeriod_f4e3c96d-2bbb-4edd-8853-308948497bc6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Cash_1ff9a98a-e7d7-42ad-89cd-0544abb21d02" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Cash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_calx_ScheduleOfCertainTermsLineItemsLineItems_19c87865-bb4d-4b19-9ebf-d97c7f658027" xlink:to="loc_us-gaap_Cash_1ff9a98a-e7d7-42ad-89cd-0544abb21d02" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_416689bb-6d56-40c2-a826-d79a52ad9670" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_calx_ScheduleOfCertainTermsLineItemsLineItems_19c87865-bb4d-4b19-9ebf-d97c7f658027" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_416689bb-6d56-40c2-a826-d79a52ad9670" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_12565652-3892-42e7-a493-f589be3ad208" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_calx_ScheduleOfCertainTermsLineItemsLineItems_19c87865-bb4d-4b19-9ebf-d97c7f658027" xlink:to="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_12565652-3892-42e7-a493-f589be3ad208" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_5e9cc701-3939-4fab-ba24-a2badc86530f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_calx_ScheduleOfCertainTermsLineItemsLineItems_19c87865-bb4d-4b19-9ebf-d97c7f658027" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_5e9cc701-3939-4fab-ba24-a2badc86530f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_ScheduleOfCertainTermsTableTable_d5da9a14-864d-4082-9279-db6500f28fbd" xlink:href="calx-20221231.xsd#calx_ScheduleOfCertainTermsTableTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_calx_ScheduleOfCertainTermsLineItemsLineItems_19c87865-bb4d-4b19-9ebf-d97c7f658027" xlink:to="loc_calx_ScheduleOfCertainTermsTableTable_d5da9a14-864d-4082-9279-db6500f28fbd" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_e1908e0f-3af2-46b7-9220-930801750d9a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_calx_ScheduleOfCertainTermsTableTable_d5da9a14-864d-4082-9279-db6500f28fbd" xlink:to="loc_srt_RangeAxis_e1908e0f-3af2-46b7-9220-930801750d9a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_e1908e0f-3af2-46b7-9220-930801750d9a_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_e1908e0f-3af2-46b7-9220-930801750d9a" xlink:to="loc_srt_RangeMember_e1908e0f-3af2-46b7-9220-930801750d9a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_8f53c8a4-9c25-4f71-9684-55256301154c" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_e1908e0f-3af2-46b7-9220-930801750d9a" xlink:to="loc_srt_RangeMember_8f53c8a4-9c25-4f71-9684-55256301154c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_05b3fa91-dc5c-4c6e-9b6c-006e04137590" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_8f53c8a4-9c25-4f71-9684-55256301154c" xlink:to="loc_srt_MinimumMember_05b3fa91-dc5c-4c6e-9b6c-006e04137590" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_6fc347ed-7a1a-4207-ae97-43493948cd9a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_8f53c8a4-9c25-4f71-9684-55256301154c" xlink:to="loc_srt_MaximumMember_6fc347ed-7a1a-4207-ae97-43493948cd9a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesAxis_1a8f13b6-03d3-4248-abd3-a18ed6f65658" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_calx_ScheduleOfCertainTermsTableTable_d5da9a14-864d-4082-9279-db6500f28fbd" xlink:to="loc_srt_ConsolidatedEntitiesAxis_1a8f13b6-03d3-4248-abd3-a18ed6f65658" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesDomain_1a8f13b6-03d3-4248-abd3-a18ed6f65658_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ConsolidatedEntitiesAxis_1a8f13b6-03d3-4248-abd3-a18ed6f65658" xlink:to="loc_srt_ConsolidatedEntitiesDomain_1a8f13b6-03d3-4248-abd3-a18ed6f65658_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ConsolidatedEntitiesDomain_20e22431-eae6-4e13-8ce8-8479754504ab" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ConsolidatedEntitiesAxis_1a8f13b6-03d3-4248-abd3-a18ed6f65658" xlink:to="loc_srt_ConsolidatedEntitiesDomain_20e22431-eae6-4e13-8ce8-8479754504ab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SubsidiariesMember_96e2c6c6-1249-442b-87e7-aac603d685d5" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SubsidiariesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ConsolidatedEntitiesDomain_20e22431-eae6-4e13-8ce8-8479754504ab" xlink:to="loc_srt_SubsidiariesMember_96e2c6c6-1249-442b-87e7-aac603d685d5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_859c5d06-cca4-4178-aca9-dc320efc933c" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_calx_ScheduleOfCertainTermsTableTable_d5da9a14-864d-4082-9279-db6500f28fbd" xlink:to="loc_srt_StatementGeographicalAxis_859c5d06-cca4-4178-aca9-dc320efc933c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_859c5d06-cca4-4178-aca9-dc320efc933c_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_859c5d06-cca4-4178-aca9-dc320efc933c" xlink:to="loc_srt_SegmentGeographicalDomain_859c5d06-cca4-4178-aca9-dc320efc933c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_53756451-188b-4d8e-9257-ee2a24c4631b" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_859c5d06-cca4-4178-aca9-dc320efc933c" xlink:to="loc_srt_SegmentGeographicalDomain_53756451-188b-4d8e-9257-ee2a24c4631b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_BrazilChinaAndUnitedKingdomMember_e854da6d-217a-4411-b474-929e2c7245fa" xlink:href="calx-20221231.xsd#calx_BrazilChinaAndUnitedKingdomMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_53756451-188b-4d8e-9257-ee2a24c4631b" xlink:to="loc_calx_BrazilChinaAndUnitedKingdomMember_e854da6d-217a-4411-b474-929e2c7245fa" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/CashCashEquivalentsandMarketableSecuritiesDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#CashCashEquivalentsandMarketableSecuritiesDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/CashCashEquivalentsandMarketableSecuritiesDetails" xlink:type="extended" id="i3da89a7bbcb241c69403ddda51889845_CashCashEquivalentsandMarketableSecuritiesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsLineItems_2289cc85-d076-4383-8f61-0dc433dd65cd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Cash_1d76b92b-39e7-43f4-879a-6d49de640d66" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Cash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashAndCashEquivalentsLineItems_2289cc85-d076-4383-8f61-0dc433dd65cd" xlink:to="loc_us-gaap_Cash_1d76b92b-39e7-43f4-879a-6d49de640d66" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashEquivalentsAtCarryingValue_9e337fc8-ea06-43fe-acc2-32b7ecb70f43" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashAndCashEquivalentsLineItems_2289cc85-d076-4383-8f61-0dc433dd65cd" xlink:to="loc_us-gaap_CashEquivalentsAtCarryingValue_9e337fc8-ea06-43fe-acc2-32b7ecb70f43" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_47949f34-d72d-4a4a-b989-6f56b1dad1ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashAndCashEquivalentsLineItems_2289cc85-d076-4383-8f61-0dc433dd65cd" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_47949f34-d72d-4a4a-b989-6f56b1dad1ca" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent_971db2d5-526e-464b-9cc8-0e27cef58e3a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashAndCashEquivalentsLineItems_2289cc85-d076-4383-8f61-0dc433dd65cd" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent_971db2d5-526e-464b-9cc8-0e27cef58e3a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_CashCashEquivalentsAndMarketableSecurities_39468f7f-6248-4bb5-a500-5b77436d8615" xlink:href="calx-20221231.xsd#calx_CashCashEquivalentsAndMarketableSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashAndCashEquivalentsLineItems_2289cc85-d076-4383-8f61-0dc433dd65cd" xlink:to="loc_calx_CashCashEquivalentsAndMarketableSecurities_39468f7f-6248-4bb5-a500-5b77436d8615" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTerm_1b0df09f-5fab-4092-a58e-26ab263852c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashAndCashEquivalentsLineItems_2289cc85-d076-4383-8f61-0dc433dd65cd" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTerm_1b0df09f-5fab-4092-a58e-26ab263852c8" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCashAndCashEquivalentsTable_6bef55bb-3d89-4f58-8ff6-585c906d28bc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfCashAndCashEquivalentsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_CashAndCashEquivalentsLineItems_2289cc85-d076-4383-8f61-0dc433dd65cd" xlink:to="loc_us-gaap_ScheduleOfCashAndCashEquivalentsTable_6bef55bb-3d89-4f58-8ff6-585c906d28bc" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAxis_add4a386-4911-4ed4-bbd8-dd660ba8a9c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCashAndCashEquivalentsTable_6bef55bb-3d89-4f58-8ff6-585c906d28bc" xlink:to="loc_us-gaap_CashAndCashEquivalentsAxis_add4a386-4911-4ed4-bbd8-dd660ba8a9c7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_add4a386-4911-4ed4-bbd8-dd660ba8a9c7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_add4a386-4911-4ed4-bbd8-dd660ba8a9c7" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_add4a386-4911-4ed4-bbd8-dd660ba8a9c7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_d80cf9f8-22e0-42ac-a289-0de30c4a58e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_add4a386-4911-4ed4-bbd8-dd660ba8a9c7" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_d80cf9f8-22e0-42ac-a289-0de30c4a58e4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashMember_99eb019f-0d31-4170-ac09-28fd1caeb3d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_d80cf9f8-22e0-42ac-a289-0de30c4a58e4" xlink:to="loc_us-gaap_CashMember_99eb019f-0d31-4170-ac09-28fd1caeb3d1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_74c838b4-894d-4643-a24a-df07e16c3ce2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialPaperMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_d80cf9f8-22e0-42ac-a289-0de30c4a58e4" xlink:to="loc_us-gaap_CommercialPaperMember_74c838b4-894d-4643-a24a-df07e16c3ce2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentDebtSecuritiesMember_93c31a0d-b175-4ccd-8136-732a53e1b8d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_d80cf9f8-22e0-42ac-a289-0de30c4a58e4" xlink:to="loc_us-gaap_USGovernmentDebtSecuritiesMember_93c31a0d-b175-4ccd-8136-732a53e1b8d1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_958ce0f9-b54c-4aaa-921a-345372a30b4d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_d80cf9f8-22e0-42ac-a289-0de30c4a58e4" xlink:to="loc_us-gaap_MoneyMarketFundsMember_958ce0f9-b54c-4aaa-921a-345372a30b4d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_02d5dbf4-dc21-4871-b0d6-ccec4c3b75c3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_d80cf9f8-22e0-42ac-a289-0de30c4a58e4" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_02d5dbf4-dc21-4871-b0d6-ccec4c3b75c3" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_406c62e8-82c3-4945-ae64-b07ecf367e8c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCashAndCashEquivalentsTable_6bef55bb-3d89-4f58-8ff6-585c906d28bc" xlink:to="loc_us-gaap_FinancialInstrumentAxis_406c62e8-82c3-4945-ae64-b07ecf367e8c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_406c62e8-82c3-4945-ae64-b07ecf367e8c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_406c62e8-82c3-4945-ae64-b07ecf367e8c" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_406c62e8-82c3-4945-ae64-b07ecf367e8c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_75fc01f2-31a6-4105-b18f-d45a59abda24" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_406c62e8-82c3-4945-ae64-b07ecf367e8c" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_75fc01f2-31a6-4105-b18f-d45a59abda24" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentDebtSecuritiesMember_102dbfb7-0b88-48ad-bf78-0616e0d8febf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_75fc01f2-31a6-4105-b18f-d45a59abda24" xlink:to="loc_us-gaap_USGovernmentDebtSecuritiesMember_102dbfb7-0b88-48ad-bf78-0616e0d8febf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_60321ad9-077b-4462-bfe0-b2d49c015626" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialPaperMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_75fc01f2-31a6-4105-b18f-d45a59abda24" xlink:to="loc_us-gaap_CommercialPaperMember_60321ad9-077b-4462-bfe0-b2d49c015626" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_6b2fd713-b996-4dd8-bbce-e0ea5a475f31" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_75fc01f2-31a6-4105-b18f-d45a59abda24" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_6b2fd713-b996-4dd8-bbce-e0ea5a475f31" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_12109075-5729-43c6-a208-4a11e043325e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_75fc01f2-31a6-4105-b18f-d45a59abda24" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_12109075-5729-43c6-a208-4a11e043325e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MunicipalNotesMember_25aef531-5c12-418e-9676-d3989bf07e2d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MunicipalNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_75fc01f2-31a6-4105-b18f-d45a59abda24" xlink:to="loc_us-gaap_MunicipalNotesMember_25aef531-5c12-418e-9676-d3989bf07e2d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_992bbfa0-bbe3-42bf-949e-0821835c6206" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfCashAndCashEquivalentsTable_6bef55bb-3d89-4f58-8ff6-585c906d28bc" xlink:to="loc_srt_RangeAxis_992bbfa0-bbe3-42bf-949e-0821835c6206" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_992bbfa0-bbe3-42bf-949e-0821835c6206_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_992bbfa0-bbe3-42bf-949e-0821835c6206" xlink:to="loc_srt_RangeMember_992bbfa0-bbe3-42bf-949e-0821835c6206_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_c3c21d64-76f4-414f-8945-5eadf2011874" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_992bbfa0-bbe3-42bf-949e-0821835c6206" xlink:to="loc_srt_RangeMember_c3c21d64-76f4-414f-8945-5eadf2011874" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_9db422f7-0496-45cc-8814-c7ebed68f6b6" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_c3c21d64-76f4-414f-8945-5eadf2011874" xlink:to="loc_srt_MaximumMember_9db422f7-0496-45cc-8814-c7ebed68f6b6" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/CashCashEquivalentsandMarketableSecuritiesScheduleofMarketableSecuritiesDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#CashCashEquivalentsandMarketableSecuritiesScheduleofMarketableSecuritiesDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/CashCashEquivalentsandMarketableSecuritiesScheduleofMarketableSecuritiesDetails" xlink:type="extended" id="i1ef5ed5ac7834f128b6bb7a7aff126bd_CashCashEquivalentsandMarketableSecuritiesScheduleofMarketableSecuritiesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_52289a51-ad7e-4770-a5a6-07cd04d4e719" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossCurrent_c40ab620-abf7-4f9f-b127-5ef8779e71d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_52289a51-ad7e-4770-a5a6-07cd04d4e719" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostExcludingAccruedInterestAfterAllowanceForCreditLossCurrent_c40ab620-abf7-4f9f-b127-5ef8779e71d6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_c686595f-aea4-41b5-b56e-2972d4c8e266" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_52289a51-ad7e-4770-a5a6-07cd04d4e719" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_c686595f-aea4-41b5-b56e-2972d4c8e266" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent_cc41bd6d-a098-4fd2-816a-1156d05d27cb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_52289a51-ad7e-4770-a5a6-07cd04d4e719" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent_cc41bd6d-a098-4fd2-816a-1156d05d27cb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_cca145f2-47cb-4f5f-aa53-9525c0c2a4a7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_52289a51-ad7e-4770-a5a6-07cd04d4e719" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_cca145f2-47cb-4f5f-aa53-9525c0c2a4a7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_2a002ef4-f0bd-40ef-8b44-360d6997de01" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_cca145f2-47cb-4f5f-aa53-9525c0c2a4a7" xlink:to="loc_us-gaap_FinancialInstrumentAxis_2a002ef4-f0bd-40ef-8b44-360d6997de01" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2a002ef4-f0bd-40ef-8b44-360d6997de01_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_2a002ef4-f0bd-40ef-8b44-360d6997de01" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2a002ef4-f0bd-40ef-8b44-360d6997de01_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_d6ba8d46-1adc-4e8d-a98c-daca21a241cf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_2a002ef4-f0bd-40ef-8b44-360d6997de01" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_d6ba8d46-1adc-4e8d-a98c-daca21a241cf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentDebtSecuritiesMember_d63d2158-31ba-44e7-b3e5-9d5506a76166" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_d6ba8d46-1adc-4e8d-a98c-daca21a241cf" xlink:to="loc_us-gaap_USGovernmentDebtSecuritiesMember_d63d2158-31ba-44e7-b3e5-9d5506a76166" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_c67bd137-f403-40f2-842b-d9c51d1ff661" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialPaperMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_d6ba8d46-1adc-4e8d-a98c-daca21a241cf" xlink:to="loc_us-gaap_CommercialPaperMember_c67bd137-f403-40f2-842b-d9c51d1ff661" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_ed1e654c-0672-4d7e-91a8-b47ede61d1e8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_d6ba8d46-1adc-4e8d-a98c-daca21a241cf" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_ed1e654c-0672-4d7e-91a8-b47ede61d1e8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_68d7585f-f003-459a-8e39-c787348e0d42" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_d6ba8d46-1adc-4e8d-a98c-daca21a241cf" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_68d7585f-f003-459a-8e39-c787348e0d42" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MunicipalNotesMember_f7bfdbc3-b2ca-4de4-83ca-ce5101b2ad81" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MunicipalNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_d6ba8d46-1adc-4e8d-a98c-daca21a241cf" xlink:to="loc_us-gaap_MunicipalNotesMember_f7bfdbc3-b2ca-4de4-83ca-ce5101b2ad81" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_a5592e37-9419-4bed-a0aa-2012482456a7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_cca145f2-47cb-4f5f-aa53-9525c0c2a4a7" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_a5592e37-9419-4bed-a0aa-2012482456a7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_a5592e37-9419-4bed-a0aa-2012482456a7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_a5592e37-9419-4bed-a0aa-2012482456a7" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_a5592e37-9419-4bed-a0aa-2012482456a7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_c342979b-9a8e-4398-beb8-1c02b4855996" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_a5592e37-9419-4bed-a0aa-2012482456a7" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_c342979b-9a8e-4398-beb8-1c02b4855996" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_ShortTermMarketableSecuritiesAndCashEquivalentsMember_1f2df069-bfa7-4318-bc82-f554007334e1" xlink:href="calx-20221231.xsd#calx_ShortTermMarketableSecuritiesAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_c342979b-9a8e-4398-beb8-1c02b4855996" xlink:to="loc_calx_ShortTermMarketableSecuritiesAndCashEquivalentsMember_1f2df069-bfa7-4318-bc82-f554007334e1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_ShortTermMarketableSecuritiesMember_87428955-f12e-41f9-9777-eb164858f9b8" xlink:href="calx-20221231.xsd#calx_ShortTermMarketableSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_calx_ShortTermMarketableSecuritiesAndCashEquivalentsMember_1f2df069-bfa7-4318-bc82-f554007334e1" xlink:to="loc_calx_ShortTermMarketableSecuritiesMember_87428955-f12e-41f9-9777-eb164858f9b8" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/FairValueMeasurementsDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#FairValueMeasurementsDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/FairValueMeasurementsDetails" xlink:type="extended" id="i649e1a837b12408c916dd41a7c9889f4_FairValueMeasurementsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7bfc38bb-11e1-47a9-a368-05f6914cb5c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashEquivalentsAtCarryingValue_6626f6af-158f-4a2f-9dbd-36009c82e2e8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashEquivalentsAtCarryingValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7bfc38bb-11e1-47a9-a368-05f6914cb5c7" xlink:to="loc_us-gaap_CashEquivalentsAtCarryingValue_6626f6af-158f-4a2f-9dbd-36009c82e2e8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent_39599d56-1a0b-4850-af6c-41aaab0aea04" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7bfc38bb-11e1-47a9-a368-05f6914cb5c7" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleExcludingAccruedInterestCurrent_39599d56-1a0b-4850-af6c-41aaab0aea04" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_7b441aff-2ee4-4175-b210-c5eab6c15a26" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7bfc38bb-11e1-47a9-a368-05f6914cb5c7" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_7b441aff-2ee4-4175-b210-c5eab6c15a26" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_5d7047ec-3954-42fb-844a-0c1e620aed72" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7bfc38bb-11e1-47a9-a368-05f6914cb5c7" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_5d7047ec-3954-42fb-844a-0c1e620aed72" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_e1ece357-0cb2-4765-adb0-b3dd15b98960" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_5d7047ec-3954-42fb-844a-0c1e620aed72" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_e1ece357-0cb2-4765-adb0-b3dd15b98960" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_e1ece357-0cb2-4765-adb0-b3dd15b98960_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_e1ece357-0cb2-4765-adb0-b3dd15b98960" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_e1ece357-0cb2-4765-adb0-b3dd15b98960_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_caa81b5a-9ef6-48e7-8f82-583f2c05cd54" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_e1ece357-0cb2-4765-adb0-b3dd15b98960" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_caa81b5a-9ef6-48e7-8f82-583f2c05cd54" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_eae1b1c8-6d13-49e7-82b5-6540c8c76295" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_caa81b5a-9ef6-48e7-8f82-583f2c05cd54" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_eae1b1c8-6d13-49e7-82b5-6540c8c76295" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAxis_cbe2938c-7c64-416a-bf16-8b7fa04f2ed1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_5d7047ec-3954-42fb-844a-0c1e620aed72" xlink:to="loc_us-gaap_CashAndCashEquivalentsAxis_cbe2938c-7c64-416a-bf16-8b7fa04f2ed1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_cbe2938c-7c64-416a-bf16-8b7fa04f2ed1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_cbe2938c-7c64-416a-bf16-8b7fa04f2ed1" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_cbe2938c-7c64-416a-bf16-8b7fa04f2ed1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_6c505cf1-ff57-4d9b-8989-42a3cb475891" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_cbe2938c-7c64-416a-bf16-8b7fa04f2ed1" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_6c505cf1-ff57-4d9b-8989-42a3cb475891" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_2a0adfe1-5de4-423c-9efc-b549de1eb4bd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_6c505cf1-ff57-4d9b-8989-42a3cb475891" xlink:to="loc_us-gaap_MoneyMarketFundsMember_2a0adfe1-5de4-423c-9efc-b549de1eb4bd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_8e411f2f-aacf-4d48-8f16-e367bc38db6c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_5d7047ec-3954-42fb-844a-0c1e620aed72" xlink:to="loc_us-gaap_FinancialInstrumentAxis_8e411f2f-aacf-4d48-8f16-e367bc38db6c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8e411f2f-aacf-4d48-8f16-e367bc38db6c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_8e411f2f-aacf-4d48-8f16-e367bc38db6c" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_8e411f2f-aacf-4d48-8f16-e367bc38db6c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1c795ef9-f4de-4874-807d-b9c1c976e615" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_8e411f2f-aacf-4d48-8f16-e367bc38db6c" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1c795ef9-f4de-4874-807d-b9c1c976e615" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentDebtSecuritiesMember_89892a71-516b-4bb0-9810-c623cf1630f6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1c795ef9-f4de-4874-807d-b9c1c976e615" xlink:to="loc_us-gaap_USGovernmentDebtSecuritiesMember_89892a71-516b-4bb0-9810-c623cf1630f6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_c1f2be9a-b5f4-4856-9bf7-de13d044b2a5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialPaperMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1c795ef9-f4de-4874-807d-b9c1c976e615" xlink:to="loc_us-gaap_CommercialPaperMember_c1f2be9a-b5f4-4856-9bf7-de13d044b2a5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_a69433fd-51fc-44f4-85a7-c179bb7e032d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1c795ef9-f4de-4874-807d-b9c1c976e615" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_a69433fd-51fc-44f4-85a7-c179bb7e032d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_24eb96de-1ea0-4654-b2f0-792a8e8879d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1c795ef9-f4de-4874-807d-b9c1c976e615" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_24eb96de-1ea0-4654-b2f0-792a8e8879d6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MunicipalNotesMember_1c36dcc3-e6c2-4839-9fa6-14a0509efb71" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MunicipalNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1c795ef9-f4de-4874-807d-b9c1c976e615" xlink:to="loc_us-gaap_MunicipalNotesMember_1c36dcc3-e6c2-4839-9fa6-14a0509efb71" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_f15140b3-4676-4f06-9e86-65ad221475f5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_5d7047ec-3954-42fb-844a-0c1e620aed72" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_f15140b3-4676-4f06-9e86-65ad221475f5" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_f15140b3-4676-4f06-9e86-65ad221475f5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_f15140b3-4676-4f06-9e86-65ad221475f5" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_f15140b3-4676-4f06-9e86-65ad221475f5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ebb5adec-f300-46d8-a6ee-5704982da59c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_f15140b3-4676-4f06-9e86-65ad221475f5" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ebb5adec-f300-46d8-a6ee-5704982da59c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_8f86c367-731d-460f-b01a-5bc0aa84ffe8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ebb5adec-f300-46d8-a6ee-5704982da59c" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_8f86c367-731d-460f-b01a-5bc0aa84ffe8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_6a424011-123a-4081-a8da-3a82f1d32ce5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ebb5adec-f300-46d8-a6ee-5704982da59c" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_6a424011-123a-4081-a8da-3a82f1d32ce5" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/BalanceSheetDetailsAllowanceandProductReturnReserveDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#BalanceSheetDetailsAllowanceandProductReturnReserveDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/BalanceSheetDetailsAllowanceandProductReturnReserveDetails" xlink:type="extended" id="ib78afa25b3284de7bc788125c2c6dab3_BalanceSheetDetailsAllowanceandProductReturnReserveDetails">
    <link:loc xlink:type="locator" xlink:label="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_a07c8de2-7ba6-42f6-8194-3710c69cac82" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ValuationAndQualifyingAccountsDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_75fc3379-032e-46bd-a294-b6afbca158cd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MovementInValuationAllowancesAndReservesRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_a07c8de2-7ba6-42f6-8194-3710c69cac82" xlink:to="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_75fc3379-032e-46bd-a294-b6afbca158cd" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesBalance_917143fc-bebc-47c6-9184-4fb043b073cf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesBalance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_75fc3379-032e-46bd-a294-b6afbca158cd" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesBalance_917143fc-bebc-47c6-9184-4fb043b073cf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_8a43fcd6-0d5a-4acf-8cc4-725e046e9f11" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_75fc3379-032e-46bd-a294-b6afbca158cd" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_8a43fcd6-0d5a-4acf-8cc4-725e046e9f11" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDeductions_ccb004da-14f2-4706-ac13-7b37acc4b3ae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesDeductions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_75fc3379-032e-46bd-a294-b6afbca158cd" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDeductions_ccb004da-14f2-4706-ac13-7b37acc4b3ae" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesBalance_f558df66-6023-4764-8baa-bafa96625fd6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesBalance"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_88d2bb1b-24af-4f31-aef9-6e046efaa9cf" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ValuationAndQualifyingAccountsDisclosureTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_a07c8de2-7ba6-42f6-8194-3710c69cac82" xlink:to="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_88d2bb1b-24af-4f31-aef9-6e046efaa9cf" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_f6bfd6d5-36cd-43bc-ae70-ca5c7caf1c9f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_88d2bb1b-24af-4f31-aef9-6e046efaa9cf" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_f6bfd6d5-36cd-43bc-ae70-ca5c7caf1c9f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_f6bfd6d5-36cd-43bc-ae70-ca5c7caf1c9f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_f6bfd6d5-36cd-43bc-ae70-ca5c7caf1c9f" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_f6bfd6d5-36cd-43bc-ae70-ca5c7caf1c9f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_7aae4d14-5441-4f9c-a0be-1b9067dcc024" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_f6bfd6d5-36cd-43bc-ae70-ca5c7caf1c9f" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_7aae4d14-5441-4f9c-a0be-1b9067dcc024" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllowanceForCreditLossMember_35d11e99-4d97-4fea-9cb5-4e07d798af71" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllowanceForCreditLossMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_7aae4d14-5441-4f9c-a0be-1b9067dcc024" xlink:to="loc_us-gaap_AllowanceForCreditLossMember_35d11e99-4d97-4fea-9cb5-4e07d798af71" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_SECSchedule1209ReserveProductReturnsMember_a7bc622a-d913-4cc0-8737-ac070ed36d93" xlink:href="calx-20221231.xsd#calx_SECSchedule1209ReserveProductReturnsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_7aae4d14-5441-4f9c-a0be-1b9067dcc024" xlink:to="loc_calx_SECSchedule1209ReserveProductReturnsMember_a7bc622a-d913-4cc0-8737-ac070ed36d93" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/BalanceSheetDetailsPropertyandEquipmentnetDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#BalanceSheetDetailsPropertyandEquipmentnetDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/BalanceSheetDetailsPropertyandEquipmentnetDetails" xlink:type="extended" id="i17fa594e5d4d4dbc8c9ae0bdb60bec2b_BalanceSheetDetailsPropertyandEquipmentnetDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cb9ae062-0a5a-4023-92de-daf2946bfd0f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_62347b7a-b149-407f-983b-7ddd868809e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cb9ae062-0a5a-4023-92de-daf2946bfd0f" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_62347b7a-b149-407f-983b-7ddd868809e0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_1c5bd084-11eb-4ec2-9e36-656b94940168" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cb9ae062-0a5a-4023-92de-daf2946bfd0f" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_1c5bd084-11eb-4ec2-9e36-656b94940168" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_2bf159be-9b98-480a-ad8f-ff4a9e051c90" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cb9ae062-0a5a-4023-92de-daf2946bfd0f" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_2bf159be-9b98-480a-ad8f-ff4a9e051c90" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_e59f9a32-0b3b-44f4-8952-491ad6347b13" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_cb9ae062-0a5a-4023-92de-daf2946bfd0f" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_e59f9a32-0b3b-44f4-8952-491ad6347b13" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_51af387c-7cad-40ce-ad8b-84fa6cd0ef5b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_e59f9a32-0b3b-44f4-8952-491ad6347b13" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_51af387c-7cad-40ce-ad8b-84fa6cd0ef5b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_51af387c-7cad-40ce-ad8b-84fa6cd0ef5b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_51af387c-7cad-40ce-ad8b-84fa6cd0ef5b" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_51af387c-7cad-40ce-ad8b-84fa6cd0ef5b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ecebac2c-b6cb-46c1-8923-4dd34f949a24" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_51af387c-7cad-40ce-ad8b-84fa6cd0ef5b" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ecebac2c-b6cb-46c1-8923-4dd34f949a24" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquipmentMember_90a0bda9-78d0-4c27-b986-505276d650d3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ecebac2c-b6cb-46c1-8923-4dd34f949a24" xlink:to="loc_us-gaap_EquipmentMember_90a0bda9-78d0-4c27-b986-505276d650d3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComputerEquipmentMember_f471e3ad-3e9f-4143-b7ef-72ce64fa61d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComputerEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ecebac2c-b6cb-46c1-8923-4dd34f949a24" xlink:to="loc_us-gaap_ComputerEquipmentMember_f471e3ad-3e9f-4143-b7ef-72ce64fa61d6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_SoftwareMember_203f0b0e-48c5-4336-ae55-d29fff096748" xlink:href="calx-20221231.xsd#calx_SoftwareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ecebac2c-b6cb-46c1-8923-4dd34f949a24" xlink:to="loc_calx_SoftwareMember_203f0b0e-48c5-4336-ae55-d29fff096748" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_440bfe96-818e-47fb-b8e4-747962460835" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ecebac2c-b6cb-46c1-8923-4dd34f949a24" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_440bfe96-818e-47fb-b8e4-747962460835" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_faff79b6-501f-47b1-93b4-7df272150aa8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FurnitureAndFixturesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_ecebac2c-b6cb-46c1-8923-4dd34f949a24" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_faff79b6-501f-47b1-93b4-7df272150aa8" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/BalanceSheetDetailsIntangibleAssetAcquisitionDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#BalanceSheetDetailsIntangibleAssetAcquisitionDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/BalanceSheetDetailsIntangibleAssetAcquisitionDetails" xlink:type="extended" id="i00dafe871d104543ac2b07f07e5a2e11_BalanceSheetDetailsIntangibleAssetAcquisitionDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_34d43079-c5ad-424a-ba94-bb6002e3a52a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_0f164e98-be04-493e-9974-bd672a177d45" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_34d43079-c5ad-424a-ba94-bb6002e3a52a" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_0f164e98-be04-493e-9974-bd672a177d45" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsMiscellaneousNoncurrent_262f361f-88a0-4a2a-99ff-9f55f38a38dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsMiscellaneousNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_34d43079-c5ad-424a-ba94-bb6002e3a52a" xlink:to="loc_us-gaap_OtherAssetsMiscellaneousNoncurrent_262f361f-88a0-4a2a-99ff-9f55f38a38dc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_bdff09bb-1b64-4d4a-84cb-c0a5f7f5db3a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_34d43079-c5ad-424a-ba94-bb6002e3a52a" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_bdff09bb-1b64-4d4a-84cb-c0a5f7f5db3a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RoyaltyGuaranteesCommitmentsAmount_13076a5a-c056-4260-9e0f-33f7e9d04b93" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RoyaltyGuaranteesCommitmentsAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_34d43079-c5ad-424a-ba94-bb6002e3a52a" xlink:to="loc_us-gaap_RoyaltyGuaranteesCommitmentsAmount_13076a5a-c056-4260-9e0f-33f7e9d04b93" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilities_0c0703fa-6468-4a1f-b065-3171a46445c0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_34d43079-c5ad-424a-ba94-bb6002e3a52a" xlink:to="loc_us-gaap_OtherLiabilities_0c0703fa-6468-4a1f-b065-3171a46445c0" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_80a76d66-e71c-424e-b3ec-0d88efda1ce0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_34d43079-c5ad-424a-ba94-bb6002e3a52a" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_80a76d66-e71c-424e-b3ec-0d88efda1ce0" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_4f2115a7-af2c-4b5d-96e3-b88d68124e1a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_34d43079-c5ad-424a-ba94-bb6002e3a52a" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_4f2115a7-af2c-4b5d-96e3-b88d68124e1a" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_20a1f7e2-bc3f-4e25-972d-2bb711c9213c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_34d43079-c5ad-424a-ba94-bb6002e3a52a" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_20a1f7e2-bc3f-4e25-972d-2bb711c9213c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_8ed85f4b-7416-4e53-bf33-3be1ac307c9e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_20a1f7e2-bc3f-4e25-972d-2bb711c9213c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_8ed85f4b-7416-4e53-bf33-3be1ac307c9e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8ed85f4b-7416-4e53-bf33-3be1ac307c9e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_8ed85f4b-7416-4e53-bf33-3be1ac307c9e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8ed85f4b-7416-4e53-bf33-3be1ac307c9e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ba5e0fad-b553-4655-94aa-415fb0b37163" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_8ed85f4b-7416-4e53-bf33-3be1ac307c9e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ba5e0fad-b553-4655-94aa-415fb0b37163" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComputerSoftwareIntangibleAssetMember_0cf0f229-cfdb-4cdf-a667-28081748ec52" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComputerSoftwareIntangibleAssetMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_ba5e0fad-b553-4655-94aa-415fb0b37163" xlink:to="loc_us-gaap_ComputerSoftwareIntangibleAssetMember_0cf0f229-cfdb-4cdf-a667-28081748ec52" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/BalanceSheetDetailsRestructuringDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#BalanceSheetDetailsRestructuringDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/BalanceSheetDetailsRestructuringDetails" xlink:type="extended" id="ie4c2b074285941f69c0279e366c47876_BalanceSheetDetailsRestructuringDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_443e1794-216b-4989-9381-d93237703cf4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCharges_a54e71f9-71db-4d33-8e9e-1d6eeecde72c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_443e1794-216b-4989-9381-d93237703cf4" xlink:to="loc_us-gaap_RestructuringCharges_a54e71f9-71db-4d33-8e9e-1d6eeecde72c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve_3fe6bd72-2695-4df2-a6ee-6f6315319ae6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringReserve"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_443e1794-216b-4989-9381-d93237703cf4" xlink:to="loc_us-gaap_RestructuringReserve_3fe6bd72-2695-4df2-a6ee-6f6315319ae6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_46b5c706-97d1-4507-8a42-e1b72f6a84a9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_443e1794-216b-4989-9381-d93237703cf4" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_46b5c706-97d1-4507-8a42-e1b72f6a84a9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanAxis_40d3a3db-c943-414c-b849-c5fe6b45ec03" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringPlanAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_46b5c706-97d1-4507-8a42-e1b72f6a84a9" xlink:to="loc_us-gaap_RestructuringPlanAxis_40d3a3db-c943-414c-b849-c5fe6b45ec03" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_40d3a3db-c943-414c-b849-c5fe6b45ec03_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringPlanAxis_40d3a3db-c943-414c-b849-c5fe6b45ec03" xlink:to="loc_us-gaap_RestructuringPlanDomain_40d3a3db-c943-414c-b849-c5fe6b45ec03_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringPlanDomain_9de90ba6-5969-4fa2-9ba3-4ddba0d559d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringPlanDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringPlanAxis_40d3a3db-c943-414c-b849-c5fe6b45ec03" xlink:to="loc_us-gaap_RestructuringPlanDomain_9de90ba6-5969-4fa2-9ba3-4ddba0d559d0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_AllPlatformFutureAndWorkFromAnywhereCultureAlignmentMember_3c53e291-3c23-4c04-a61c-c5c4d4a2678f" xlink:href="calx-20221231.xsd#calx_AllPlatformFutureAndWorkFromAnywhereCultureAlignmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringPlanDomain_9de90ba6-5969-4fa2-9ba3-4ddba0d559d0" xlink:to="loc_calx_AllPlatformFutureAndWorkFromAnywhereCultureAlignmentMember_3c53e291-3c23-4c04-a61c-c5c4d4a2678f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_12cb3112-1004-4fd1-9f12-435027b62999" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_46b5c706-97d1-4507-8a42-e1b72f6a84a9" xlink:to="loc_srt_StatementGeographicalAxis_12cb3112-1004-4fd1-9f12-435027b62999" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_12cb3112-1004-4fd1-9f12-435027b62999_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_12cb3112-1004-4fd1-9f12-435027b62999" xlink:to="loc_srt_SegmentGeographicalDomain_12cb3112-1004-4fd1-9f12-435027b62999_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_ac3de07e-cbae-4129-aaa2-5cfd4d588160" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_12cb3112-1004-4fd1-9f12-435027b62999" xlink:to="loc_srt_SegmentGeographicalDomain_ac3de07e-cbae-4129-aaa2-5cfd4d588160" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_SanJoseCaliforniaMember_81133e60-bcbb-4b53-b03d-e13ef95fcc0f" xlink:href="calx-20221231.xsd#calx_SanJoseCaliforniaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_ac3de07e-cbae-4129-aaa2-5cfd4d588160" xlink:to="loc_calx_SanJoseCaliforniaMember_81133e60-bcbb-4b53-b03d-e13ef95fcc0f" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/CommitmentsandContingenciesTextualDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#CommitmentsandContingenciesTextualDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/CommitmentsandContingenciesTextualDetails" xlink:type="extended" id="i64f5616be81c415898ae3223ec673913_CommitmentsandContingenciesTextualDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_0ebf4805-2153-496c-af71-0795fafd9f92" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_542b0382-54fb-41a4-99e3-8a34ff8b776f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_0ebf4805-2153-496c-af71-0795fafd9f92" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_542b0382-54fb-41a4-99e3-8a34ff8b776f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_22b8391d-37d0-4b62-8236-cfdb039cc478" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_0ebf4805-2153-496c-af71-0795fafd9f92" xlink:to="loc_us-gaap_OperatingLeaseWeightedAverageDiscountRatePercent_22b8391d-37d0-4b62-8236-cfdb039cc478" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_020e779c-b5cf-40b7-9126-7ed8b4a8f758" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_0ebf4805-2153-496c-af71-0795fafd9f92" xlink:to="loc_us-gaap_OperatingLeaseWeightedAverageRemainingLeaseTerm1_020e779c-b5cf-40b7-9126-7ed8b4a8f758" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_e4d2923a-6940-45b8-a645-b94d7002113d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseCost"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_0ebf4805-2153-496c-af71-0795fafd9f92" xlink:to="loc_us-gaap_OperatingLeaseCost_e4d2923a-6940-45b8-a645-b94d7002113d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasePayments_4562699b-9df5-4e5b-95a3-45a13e3e8640" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeasePayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_0ebf4805-2153-496c-af71-0795fafd9f92" xlink:to="loc_us-gaap_OperatingLeasePayments_4562699b-9df5-4e5b-95a3-45a13e3e8640" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PurchaseCommitmentRemainingMinimumAmountCommitted_a0527839-e8b5-4a9e-ac1c-5990c8f56878" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PurchaseCommitmentRemainingMinimumAmountCommitted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_0ebf4805-2153-496c-af71-0795fafd9f92" xlink:to="loc_us-gaap_PurchaseCommitmentRemainingMinimumAmountCommitted_a0527839-e8b5-4a9e-ac1c-5990c8f56878" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_AccruedExcessAndObsoleteInventoryAtContractManufacturer_9c2687de-ddef-41d1-9e57-2cd4034011f9" xlink:href="calx-20221231.xsd#calx_AccruedExcessAndObsoleteInventoryAtContractManufacturer"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_0ebf4805-2153-496c-af71-0795fafd9f92" xlink:to="loc_calx_AccruedExcessAndObsoleteInventoryAtContractManufacturer_9c2687de-ddef-41d1-9e57-2cd4034011f9" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubleaseIncome_5d92cb29-2b54-447c-96f9-1057562921a8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubleaseIncome"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_0ebf4805-2153-496c-af71-0795fafd9f92" xlink:to="loc_us-gaap_SubleaseIncome_5d92cb29-2b54-447c-96f9-1057562921a8" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_e9c757bd-5e67-4276-83da-e8316dd6936e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_0ebf4805-2153-496c-af71-0795fafd9f92" xlink:to="loc_us-gaap_LossContingenciesTable_e9c757bd-5e67-4276-83da-e8316dd6936e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_b90a025c-8dbf-4983-844d-0ef3afd18cab" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_e9c757bd-5e67-4276-83da-e8316dd6936e" xlink:to="loc_srt_StatementGeographicalAxis_b90a025c-8dbf-4983-844d-0ef3afd18cab" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_b90a025c-8dbf-4983-844d-0ef3afd18cab_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_b90a025c-8dbf-4983-844d-0ef3afd18cab" xlink:to="loc_srt_SegmentGeographicalDomain_b90a025c-8dbf-4983-844d-0ef3afd18cab_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_549a869b-7dd7-4ad0-ace2-4d082b8b3bce" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_b90a025c-8dbf-4983-844d-0ef3afd18cab" xlink:to="loc_srt_SegmentGeographicalDomain_549a869b-7dd7-4ad0-ace2-4d082b8b3bce" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_SanJoseCaliforniaMember_7a96e0b4-f855-4451-bc77-831f4c27df08" xlink:href="calx-20221231.xsd#calx_SanJoseCaliforniaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_549a869b-7dd7-4ad0-ace2-4d082b8b3bce" xlink:to="loc_calx_SanJoseCaliforniaMember_7a96e0b4-f855-4451-bc77-831f4c27df08" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/StockholdersEquityStockOfferingTreasuryStockRetirementPreferredStockandCommonStockDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#StockholdersEquityStockOfferingTreasuryStockRetirementPreferredStockandCommonStockDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/StockholdersEquityStockOfferingTreasuryStockRetirementPreferredStockandCommonStockDetails" xlink:type="extended" id="ibeef06b9aa4c4afd9437ed372c1b1ca4_StockholdersEquityStockOfferingTreasuryStockRetirementPreferredStockandCommonStockDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bd402520-dbe3-45bd-81cd-a72bbdbedf4d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_711b2ea0-35a5-47da-bbe6-95055653d942" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bd402520-dbe3-45bd-81cd-a72bbdbedf4d" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_711b2ea0-35a5-47da-bbe6-95055653d942" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesIssued_44e6a272-aeea-4cf8-9c52-4b1383ce27d2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bd402520-dbe3-45bd-81cd-a72bbdbedf4d" xlink:to="loc_us-gaap_PreferredStockSharesIssued_44e6a272-aeea-4cf8-9c52-4b1383ce27d2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_3e73d72d-8b47-4502-b8f6-70a7dd91a874" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bd402520-dbe3-45bd-81cd-a72bbdbedf4d" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_3e73d72d-8b47-4502-b8f6-70a7dd91a874" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared_a0bccdc5-a057-462a-869a-19b7052186d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockDividendsPerShareDeclared"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bd402520-dbe3-45bd-81cd-a72bbdbedf4d" xlink:to="loc_us-gaap_CommonStockDividendsPerShareDeclared_a0bccdc5-a057-462a-869a-19b7052186d0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_06218a67-b704-47fe-a87b-46015626f17a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bd402520-dbe3-45bd-81cd-a72bbdbedf4d" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_06218a67-b704-47fe-a87b-46015626f17a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_d00a23a7-85ed-44c4-a7c2-14192f0e1a9f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bd402520-dbe3-45bd-81cd-a72bbdbedf4d" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_d00a23a7-85ed-44c4-a7c2-14192f0e1a9f" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_f46e0943-edc0-4f48-8de7-1c8f21cee83c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bd402520-dbe3-45bd-81cd-a72bbdbedf4d" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_f46e0943-edc0-4f48-8de7-1c8f21cee83c" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_5515e223-6a4e-4ea9-aad7-99905b3b0ae5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_bd402520-dbe3-45bd-81cd-a72bbdbedf4d" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_5515e223-6a4e-4ea9-aad7-99905b3b0ae5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_a12b26bf-2b14-4653-9bf0-6ecf215bc61a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_5515e223-6a4e-4ea9-aad7-99905b3b0ae5" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_a12b26bf-2b14-4653-9bf0-6ecf215bc61a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_a12b26bf-2b14-4653-9bf0-6ecf215bc61a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_a12b26bf-2b14-4653-9bf0-6ecf215bc61a" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_a12b26bf-2b14-4653-9bf0-6ecf215bc61a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_8cc05cf2-d6b9-4018-be60-dff737158c04" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_a12b26bf-2b14-4653-9bf0-6ecf215bc61a" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_8cc05cf2-d6b9-4018-be60-dff737158c04" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_PublicStockOfferingMember_6a7e1e62-e08f-4d74-8899-60bee46c43e4" xlink:href="calx-20221231.xsd#calx_PublicStockOfferingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_8cc05cf2-d6b9-4018-be60-dff737158c04" xlink:to="loc_calx_PublicStockOfferingMember_6a7e1e62-e08f-4d74-8899-60bee46c43e4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OverAllotmentOptionMember_d01afc1f-2066-40c7-832f-db102ed994e7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OverAllotmentOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_8cc05cf2-d6b9-4018-be60-dff737158c04" xlink:to="loc_us-gaap_OverAllotmentOptionMember_d01afc1f-2066-40c7-832f-db102ed994e7" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/StockholdersEquityEquityIncentivePlansDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#StockholdersEquityEquityIncentivePlansDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/StockholdersEquityEquityIncentivePlansDetails" xlink:type="extended" id="i75108b61dd304b6dbe8e5626fbd80a2b_StockholdersEquityEquityIncentivePlansDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_80d557bc-c1a8-4d62-a123-bcdac25b891d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantAdditionalShares_8e12bd85-0968-4e5d-a31b-40510a49c170" xlink:href="calx-20221231.xsd#calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantAdditionalShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_80d557bc-c1a8-4d62-a123-bcdac25b891d" xlink:to="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantAdditionalShares_8e12bd85-0968-4e5d-a31b-40510a49c170" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_9069d8cd-9e99-4c75-8267-0055e0ecfe87" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_80d557bc-c1a8-4d62-a123-bcdac25b891d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_9069d8cd-9e99-4c75-8267-0055e0ecfe87" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_MinimumExercisePriceOfStockOptionPercent_65597541-934b-423b-989c-c46af355474f" xlink:href="calx-20221231.xsd#calx_MinimumExercisePriceOfStockOptionPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_80d557bc-c1a8-4d62-a123-bcdac25b891d" xlink:to="loc_calx_MinimumExercisePriceOfStockOptionPercent_65597541-934b-423b-989c-c46af355474f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_a87c256e-faaa-4e88-aaf5-ad15db13e71a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_80d557bc-c1a8-4d62-a123-bcdac25b891d" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_a87c256e-faaa-4e88-aaf5-ad15db13e71a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_bbae5cf6-e931-44ff-83fa-aa621d9a2cee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_80d557bc-c1a8-4d62-a123-bcdac25b891d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_bbae5cf6-e931-44ff-83fa-aa621d9a2cee" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_ContractualTermStockOptions_6ae62ea8-dc5b-43fa-8237-b107090e40af" xlink:href="calx-20221231.xsd#calx_ContractualTermStockOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_80d557bc-c1a8-4d62-a123-bcdac25b891d" xlink:to="loc_calx_ContractualTermStockOptions_6ae62ea8-dc5b-43fa-8237-b107090e40af" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_70ec692c-ed71-454c-8e6f-7ce8fe77f92f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_80d557bc-c1a8-4d62-a123-bcdac25b891d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_70ec692c-ed71-454c-8e6f-7ce8fe77f92f" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_be1c92ff-4707-4353-8459-fe5526d688b3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_80d557bc-c1a8-4d62-a123-bcdac25b891d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_be1c92ff-4707-4353-8459-fe5526d688b3" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1_24fb0d17-d23b-4889-a1cd-2f177492c6ef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_80d557bc-c1a8-4d62-a123-bcdac25b891d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1_24fb0d17-d23b-4889-a1cd-2f177492c6ef" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNetIncomePerShareTargetAchievementPerformanceThresholdPercent_c611f6f8-1628-4ffb-b58a-90aa43134703" xlink:href="calx-20221231.xsd#calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNetIncomePerShareTargetAchievementPerformanceThresholdPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_80d557bc-c1a8-4d62-a123-bcdac25b891d" xlink:to="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNetIncomePerShareTargetAchievementPerformanceThresholdPercent_c611f6f8-1628-4ffb-b58a-90aa43134703" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardBookingsTargetAchievementPerformanceThresholdPercent_f942c725-4ac4-47ea-9858-8a02f1930687" xlink:href="calx-20221231.xsd#calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardBookingsTargetAchievementPerformanceThresholdPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_80d557bc-c1a8-4d62-a123-bcdac25b891d" xlink:to="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardBookingsTargetAchievementPerformanceThresholdPercent_f942c725-4ac4-47ea-9858-8a02f1930687" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesGrantedIfTargetAchievementPerformanceThresholdNotMet_41b38fd2-5d00-435b-84e2-f712efb29172" xlink:href="calx-20221231.xsd#calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesGrantedIfTargetAchievementPerformanceThresholdNotMet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_80d557bc-c1a8-4d62-a123-bcdac25b891d" xlink:to="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesGrantedIfTargetAchievementPerformanceThresholdNotMet_41b38fd2-5d00-435b-84e2-f712efb29172" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesAwardWeightingPercentForTargetAchievementPerformanceThresholdPercent_fdabc268-2f9b-4acf-b369-4c8dea109dc5" xlink:href="calx-20221231.xsd#calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesAwardWeightingPercentForTargetAchievementPerformanceThresholdPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_80d557bc-c1a8-4d62-a123-bcdac25b891d" xlink:to="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesAwardWeightingPercentForTargetAchievementPerformanceThresholdPercent_fdabc268-2f9b-4acf-b369-4c8dea109dc5" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesAwardTargetAchievementPerformanceThresholdPercent_82d53a19-7801-4faf-bf26-197d17d10b80" xlink:href="calx-20221231.xsd#calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesAwardTargetAchievementPerformanceThresholdPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_80d557bc-c1a8-4d62-a123-bcdac25b891d" xlink:to="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesAwardTargetAchievementPerformanceThresholdPercent_82d53a19-7801-4faf-bf26-197d17d10b80" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardsPercentageOfTotalSubjectToServiceCondition_1d590a28-778e-48e9-9e4f-2e59102e8ec2" xlink:href="calx-20221231.xsd#calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardsPercentageOfTotalSubjectToServiceCondition"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_80d557bc-c1a8-4d62-a123-bcdac25b891d" xlink:to="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardsPercentageOfTotalSubjectToServiceCondition_1d590a28-778e-48e9-9e4f-2e59102e8ec2" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_PerformanceTargetsServicesConditionPeriod_499573ca-b3c4-495b-95b3-78ec9a01de66" xlink:href="calx-20221231.xsd#calx_PerformanceTargetsServicesConditionPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_80d557bc-c1a8-4d62-a123-bcdac25b891d" xlink:to="loc_calx_PerformanceTargetsServicesConditionPeriod_499573ca-b3c4-495b-95b3-78ec9a01de66" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_1ee4a36b-2572-4e5a-876b-a6848e096b70" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_80d557bc-c1a8-4d62-a123-bcdac25b891d" xlink:to="loc_us-gaap_ShareBasedCompensation_1ee4a36b-2572-4e5a-876b-a6848e096b70" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2f3e7376-e11c-4afd-8a02-c7c5f4fd6506" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_80d557bc-c1a8-4d62-a123-bcdac25b891d" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2f3e7376-e11c-4afd-8a02-c7c5f4fd6506" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_2b85119c-f87f-4e03-92da-26a5046ff8a3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2f3e7376-e11c-4afd-8a02-c7c5f4fd6506" xlink:to="loc_us-gaap_PlanNameAxis_2b85119c-f87f-4e03-92da-26a5046ff8a3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_2b85119c-f87f-4e03-92da-26a5046ff8a3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_2b85119c-f87f-4e03-92da-26a5046ff8a3" xlink:to="loc_us-gaap_PlanNameDomain_2b85119c-f87f-4e03-92da-26a5046ff8a3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_ef32a9dd-f772-4d48-b9f2-9d4f817135d5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_2b85119c-f87f-4e03-92da-26a5046ff8a3" xlink:to="loc_us-gaap_PlanNameDomain_ef32a9dd-f772-4d48-b9f2-9d4f817135d5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_A2019EquityIncentiveAwardPlanMember_16e918fa-6461-4bf7-9017-bc55e17adfd2" xlink:href="calx-20221231.xsd#calx_A2019EquityIncentiveAwardPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_ef32a9dd-f772-4d48-b9f2-9d4f817135d5" xlink:to="loc_calx_A2019EquityIncentiveAwardPlanMember_16e918fa-6461-4bf7-9017-bc55e17adfd2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_A2021PerformanceTargetsMember_66f916f4-2963-4c27-8ce1-399df7c23cf5" xlink:href="calx-20221231.xsd#calx_A2021PerformanceTargetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_ef32a9dd-f772-4d48-b9f2-9d4f817135d5" xlink:to="loc_calx_A2021PerformanceTargetsMember_66f916f4-2963-4c27-8ce1-399df7c23cf5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_8a72b450-5305-4a10-953d-26407525bdb3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2f3e7376-e11c-4afd-8a02-c7c5f4fd6506" xlink:to="loc_us-gaap_AwardTypeAxis_8a72b450-5305-4a10-953d-26407525bdb3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_8a72b450-5305-4a10-953d-26407525bdb3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_8a72b450-5305-4a10-953d-26407525bdb3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_8a72b450-5305-4a10-953d-26407525bdb3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_03c2e0e3-efe2-4b72-9685-30bdb94dd14e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_8a72b450-5305-4a10-953d-26407525bdb3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_03c2e0e3-efe2-4b72-9685-30bdb94dd14e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_f3fe978d-3a68-4e1e-bc10-b08fcaae099e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_03c2e0e3-efe2-4b72-9685-30bdb94dd14e" xlink:to="loc_us-gaap_EmployeeStockOptionMember_f3fe978d-3a68-4e1e-bc10-b08fcaae099e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_PerformanceBasedStockOptionsMember_b6e6c4cb-4b8e-4c0f-a4a2-63b849ed2dd0" xlink:href="calx-20221231.xsd#calx_PerformanceBasedStockOptionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_03c2e0e3-efe2-4b72-9685-30bdb94dd14e" xlink:to="loc_calx_PerformanceBasedStockOptionsMember_b6e6c4cb-4b8e-4c0f-a4a2-63b849ed2dd0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VestingAxis_72c08cbf-88f8-41fc-bc97-d648ab75acf7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VestingAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2f3e7376-e11c-4afd-8a02-c7c5f4fd6506" xlink:to="loc_us-gaap_VestingAxis_72c08cbf-88f8-41fc-bc97-d648ab75acf7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VestingDomain_72c08cbf-88f8-41fc-bc97-d648ab75acf7_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VestingDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VestingAxis_72c08cbf-88f8-41fc-bc97-d648ab75acf7" xlink:to="loc_us-gaap_VestingDomain_72c08cbf-88f8-41fc-bc97-d648ab75acf7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VestingDomain_ff7ce7ac-7809-4615-934c-54c4b94eab12" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VestingDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VestingAxis_72c08cbf-88f8-41fc-bc97-d648ab75acf7" xlink:to="loc_us-gaap_VestingDomain_ff7ce7ac-7809-4615-934c-54c4b94eab12" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationAwardTrancheOneMember_92314dd0-dac7-43fc-aaf0-b270969a3a74" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationAwardTrancheOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VestingDomain_ff7ce7ac-7809-4615-934c-54c4b94eab12" xlink:to="loc_us-gaap_ShareBasedCompensationAwardTrancheOneMember_92314dd0-dac7-43fc-aaf0-b270969a3a74" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationAwardTrancheTwoMember_654127c8-2c49-4f93-8cd4-7cded749b9e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationAwardTrancheTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VestingDomain_ff7ce7ac-7809-4615-934c-54c4b94eab12" xlink:to="loc_us-gaap_ShareBasedCompensationAwardTrancheTwoMember_654127c8-2c49-4f93-8cd4-7cded749b9e0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualAxis_aa9eccbf-3468-4acb-aab3-b4a081f7dbf2" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2f3e7376-e11c-4afd-8a02-c7c5f4fd6506" xlink:to="loc_srt_TitleOfIndividualAxis_aa9eccbf-3468-4acb-aab3-b4a081f7dbf2" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_aa9eccbf-3468-4acb-aab3-b4a081f7dbf2_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_TitleOfIndividualAxis_aa9eccbf-3468-4acb-aab3-b4a081f7dbf2" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_aa9eccbf-3468-4acb-aab3-b4a081f7dbf2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_a4c9efde-6edb-4884-b29a-cb6ad523841d" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_TitleOfIndividualAxis_aa9eccbf-3468-4acb-aab3-b4a081f7dbf2" xlink:to="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_a4c9efde-6edb-4884-b29a-cb6ad523841d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ExecutiveOfficerMember_c60c54e5-6863-439f-962b-6634de7e4a18" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ExecutiveOfficerMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_TitleOfIndividualWithRelationshipToEntityDomain_a4c9efde-6edb-4884-b29a-cb6ad523841d" xlink:to="loc_srt_ExecutiveOfficerMember_c60c54e5-6863-439f-962b-6634de7e4a18" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_22d15f60-23b9-4192-b278-d764436494b1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2f3e7376-e11c-4afd-8a02-c7c5f4fd6506" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_22d15f60-23b9-4192-b278-d764436494b1" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_22d15f60-23b9-4192-b278-d764436494b1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_22d15f60-23b9-4192-b278-d764436494b1" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_22d15f60-23b9-4192-b278-d764436494b1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_e999f07e-98ed-4f0a-81d5-85732f419c46" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_22d15f60-23b9-4192-b278-d764436494b1" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_e999f07e-98ed-4f0a-81d5-85732f419c46" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_8cdc8ffa-2eaa-4b2f-a6c2-e851d36096fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_e999f07e-98ed-4f0a-81d5-85732f419c46" xlink:to="loc_us-gaap_SubsequentEventMember_8cdc8ffa-2eaa-4b2f-a6c2-e851d36096fd" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/StockholdersEquityFairValueofAwardsGrantedDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#StockholdersEquityFairValueofAwardsGrantedDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/StockholdersEquityFairValueofAwardsGrantedDetails" xlink:type="extended" id="iba452e745dca4349b91d46657a36cd66_StockholdersEquityFairValueofAwardsGrantedDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_acef54e2-08fa-42d7-83c0-7ced5311b4ac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_9d9ac90b-f0f2-47ae-bdac-d909be9bba91" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_acef54e2-08fa-42d7-83c0-7ced5311b4ac" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_9d9ac90b-f0f2-47ae-bdac-d909be9bba91" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_acfe260f-0b1a-4354-837d-80b0d2e288dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_acef54e2-08fa-42d7-83c0-7ced5311b4ac" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_acfe260f-0b1a-4354-837d-80b0d2e288dc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_bcde45f3-32b6-48f2-8ba8-41f2deeeaa1f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_acef54e2-08fa-42d7-83c0-7ced5311b4ac" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_bcde45f3-32b6-48f2-8ba8-41f2deeeaa1f" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_73b7545f-c38f-4bdc-84ec-81f944141fee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_bcde45f3-32b6-48f2-8ba8-41f2deeeaa1f" xlink:to="loc_us-gaap_PlanNameAxis_73b7545f-c38f-4bdc-84ec-81f944141fee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_73b7545f-c38f-4bdc-84ec-81f944141fee_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_73b7545f-c38f-4bdc-84ec-81f944141fee" xlink:to="loc_us-gaap_PlanNameDomain_73b7545f-c38f-4bdc-84ec-81f944141fee_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_c00e7f72-05f3-4534-86e7-d3e7009ebbe4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_73b7545f-c38f-4bdc-84ec-81f944141fee" xlink:to="loc_us-gaap_PlanNameDomain_c00e7f72-05f3-4534-86e7-d3e7009ebbe4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_A2017NonqualifiedEmployeeStockPurchasePlanMember_c6f272fe-9129-4ed8-b626-35f30b45a0d5" xlink:href="calx-20221231.xsd#calx_A2017NonqualifiedEmployeeStockPurchasePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_c00e7f72-05f3-4534-86e7-d3e7009ebbe4" xlink:to="loc_calx_A2017NonqualifiedEmployeeStockPurchasePlanMember_c6f272fe-9129-4ed8-b626-35f30b45a0d5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_5235c8ef-d4ca-42bc-9b34-9b93a360293b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_bcde45f3-32b6-48f2-8ba8-41f2deeeaa1f" xlink:to="loc_us-gaap_AwardTypeAxis_5235c8ef-d4ca-42bc-9b34-9b93a360293b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_5235c8ef-d4ca-42bc-9b34-9b93a360293b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_5235c8ef-d4ca-42bc-9b34-9b93a360293b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_5235c8ef-d4ca-42bc-9b34-9b93a360293b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_f7b2f241-6a84-4d51-9659-fc8b35ba7c1b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_5235c8ef-d4ca-42bc-9b34-9b93a360293b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_f7b2f241-6a84-4d51-9659-fc8b35ba7c1b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember_8d62db37-d86d-4d77-a6cb-d9f9b10deedd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_f7b2f241-6a84-4d51-9659-fc8b35ba7c1b" xlink:to="loc_us-gaap_EmployeeStockMember_8d62db37-d86d-4d77-a6cb-d9f9b10deedd" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/StockholdersEquityStockBasedCompensationExpenseDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#StockholdersEquityStockBasedCompensationExpenseDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/StockholdersEquityStockBasedCompensationExpenseDetails" xlink:type="extended" id="i981a2f13eaf5484bb1fcaefa399c514c_StockholdersEquityStockBasedCompensationExpenseDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0334a1e4-ffdb-4dca-acd4-dccd17efaed1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_72b13d2c-5124-411b-8a39-b5146b9d43d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0334a1e4-ffdb-4dca-acd4-dccd17efaed1" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_72b13d2c-5124-411b-8a39-b5146b9d43d6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_bfb3f9aa-c418-4fbb-a004-2307c38d5578" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0334a1e4-ffdb-4dca-acd4-dccd17efaed1" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_bfb3f9aa-c418-4fbb-a004-2307c38d5578" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_PercentOfHistoricalVolatility_bc61d22f-6766-405a-b837-49105cfad7af" xlink:href="calx-20221231.xsd#calx_PercentOfHistoricalVolatility"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0334a1e4-ffdb-4dca-acd4-dccd17efaed1" xlink:to="loc_calx_PercentOfHistoricalVolatility_bc61d22f-6766-405a-b837-49105cfad7af" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_PercentOfImpliedVolatility_766e10f6-a81e-41f5-a04e-0cc3434750ad" xlink:href="calx-20221231.xsd#calx_PercentOfImpliedVolatility"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0334a1e4-ffdb-4dca-acd4-dccd17efaed1" xlink:to="loc_calx_PercentOfImpliedVolatility_766e10f6-a81e-41f5-a04e-0cc3434750ad" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_06572598-fa0b-464a-9464-162cccdb753b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0334a1e4-ffdb-4dca-acd4-dccd17efaed1" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_06572598-fa0b-464a-9464-162cccdb753b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_74839b29-ef50-4bfd-97b4-0927b40d9469" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_06572598-fa0b-464a-9464-162cccdb753b" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_74839b29-ef50-4bfd-97b4-0927b40d9469" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_74839b29-ef50-4bfd-97b4-0927b40d9469_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_74839b29-ef50-4bfd-97b4-0927b40d9469" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_74839b29-ef50-4bfd-97b4-0927b40d9469_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_cc530ee0-0922-49a7-adcd-e4218ef16176" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_74839b29-ef50-4bfd-97b4-0927b40d9469" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_cc530ee0-0922-49a7-adcd-e4218ef16176" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_CostOfRevenueProductsMember_41944a30-8354-4b34-8024-33e83b22da94" xlink:href="calx-20221231.xsd#calx_CostOfRevenueProductsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_cc530ee0-0922-49a7-adcd-e4218ef16176" xlink:to="loc_calx_CostOfRevenueProductsMember_41944a30-8354-4b34-8024-33e83b22da94" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_CostOfRevenueServicesMember_91a77800-3e1c-4873-a4b7-e42faa253253" xlink:href="calx-20221231.xsd#calx_CostOfRevenueServicesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_cc530ee0-0922-49a7-adcd-e4218ef16176" xlink:to="loc_calx_CostOfRevenueServicesMember_91a77800-3e1c-4873-a4b7-e42faa253253" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingAndMarketingExpenseMember_81e00abf-e9d3-432a-8b09-f16328fe315e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SellingAndMarketingExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_cc530ee0-0922-49a7-adcd-e4218ef16176" xlink:to="loc_us-gaap_SellingAndMarketingExpenseMember_81e00abf-e9d3-432a-8b09-f16328fe315e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_5bc2cee7-f563-4edf-8f7b-d94d4c7a4c0f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_cc530ee0-0922-49a7-adcd-e4218ef16176" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_5bc2cee7-f563-4edf-8f7b-d94d4c7a4c0f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_bf272b44-896a-4105-99e9-55c8801407e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_cc530ee0-0922-49a7-adcd-e4218ef16176" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_bf272b44-896a-4105-99e9-55c8801407e0" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/StockholdersEquityESPPDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#StockholdersEquityESPPDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/StockholdersEquityESPPDetails" xlink:type="extended" id="i8367a65faa9f479eba98c53691931ed9_StockholdersEquityESPPDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4d25f3-5938-4e2b-a8d7-8a6b74118acf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumEmployeeSubscriptionRate_8a5909c5-7093-4f0b-a5ee-ddc72201f923" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumEmployeeSubscriptionRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4d25f3-5938-4e2b-a8d7-8a6b74118acf" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumEmployeeSubscriptionRate_8a5909c5-7093-4f0b-a5ee-ddc72201f923" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee_83625f11-a5fc-45f4-8cf0-4335e255fb4d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4d25f3-5938-4e2b-a8d7-8a6b74118acf" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee_83625f11-a5fc-45f4-8cf0-4335e255fb4d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfOfferingPeriods_202e9af0-a5c3-40a2-bf37-85b94ba6e2f2" xlink:href="calx-20221231.xsd#calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfOfferingPeriods"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4d25f3-5938-4e2b-a8d7-8a6b74118acf" xlink:to="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfOfferingPeriods_202e9af0-a5c3-40a2-bf37-85b94ba6e2f2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_SharebasedCompensationArrangementbySharebasedPaymentAwardPurchasePriceofCommonStockOfferingPeriod_ac4a5f8b-a4c5-4068-bf79-5eca8e19a25e" xlink:href="calx-20221231.xsd#calx_SharebasedCompensationArrangementbySharebasedPaymentAwardPurchasePriceofCommonStockOfferingPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4d25f3-5938-4e2b-a8d7-8a6b74118acf" xlink:to="loc_calx_SharebasedCompensationArrangementbySharebasedPaymentAwardPurchasePriceofCommonStockOfferingPeriod_ac4a5f8b-a4c5-4068-bf79-5eca8e19a25e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_ad45c667-c49f-4dfa-b26f-88c17ddab3ea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4d25f3-5938-4e2b-a8d7-8a6b74118acf" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_ad45c667-c49f-4dfa-b26f-88c17ddab3ea" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_bf0469d1-f2dc-4ed9-9d5c-ca9cfeda1b78" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4d25f3-5938-4e2b-a8d7-8a6b74118acf" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_bf0469d1-f2dc-4ed9-9d5c-ca9cfeda1b78" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_b44f7f32-a176-45d3-9352-eef8db86e671" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4d25f3-5938-4e2b-a8d7-8a6b74118acf" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_b44f7f32-a176-45d3-9352-eef8db86e671" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_831c0306-03f7-4cea-966a-661d51837d2d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4d25f3-5938-4e2b-a8d7-8a6b74118acf" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_831c0306-03f7-4cea-966a-661d51837d2d" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockOwnershipPlan_0c0c4656-be38-4725-866c-cc4dcd9f0854" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockOwnershipPlan"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4d25f3-5938-4e2b-a8d7-8a6b74118acf" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockOwnershipPlan_0c0c4656-be38-4725-866c-cc4dcd9f0854" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_8c383186-4c51-4c2c-8b65-458586dc102d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4d25f3-5938-4e2b-a8d7-8a6b74118acf" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_8c383186-4c51-4c2c-8b65-458586dc102d" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_0daa64e1-0497-4d91-9cf1-64c69efd1dce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4d25f3-5938-4e2b-a8d7-8a6b74118acf" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_0daa64e1-0497-4d91-9cf1-64c69efd1dce" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumContributionPercent_db72f3d7-fddc-43d5-b6b1-f9cf877a6d07" xlink:href="calx-20221231.xsd#calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumContributionPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4d25f3-5938-4e2b-a8d7-8a6b74118acf" xlink:to="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumContributionPercent_db72f3d7-fddc-43d5-b6b1-f9cf877a6d07" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardEmployeeTerminationPeriodFollowingPurchaseDateToReceiveSharesSubjectToRiskOfForfeiture_d62c4154-1d90-4194-9472-3ebedb8f0690" xlink:href="calx-20221231.xsd#calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardEmployeeTerminationPeriodFollowingPurchaseDateToReceiveSharesSubjectToRiskOfForfeiture"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4d25f3-5938-4e2b-a8d7-8a6b74118acf" xlink:to="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardEmployeeTerminationPeriodFollowingPurchaseDateToReceiveSharesSubjectToRiskOfForfeiture_d62c4154-1d90-4194-9472-3ebedb8f0690" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorizedPerPurchasePeriod_aa307965-7b52-42e9-9378-5dfe37125e70" xlink:href="calx-20221231.xsd#calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorizedPerPurchasePeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4d25f3-5938-4e2b-a8d7-8a6b74118acf" xlink:to="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorizedPerPurchasePeriod_aa307965-7b52-42e9-9378-5dfe37125e70" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantAdditionalShares_0cf56485-9126-48be-8c34-14f055c5e5dc" xlink:href="calx-20221231.xsd#calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantAdditionalShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4d25f3-5938-4e2b-a8d7-8a6b74118acf" xlink:to="loc_calx_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantAdditionalShares_0cf56485-9126-48be-8c34-14f055c5e5dc" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_61688637-dc96-47b9-bdad-9a32d38ddbf8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4d25f3-5938-4e2b-a8d7-8a6b74118acf" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_61688637-dc96-47b9-bdad-9a32d38ddbf8" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesPurchasedForAward_9556352d-0835-475d-993f-525cb6986811" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesPurchasedForAward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4d25f3-5938-4e2b-a8d7-8a6b74118acf" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesPurchasedForAward_9556352d-0835-475d-993f-525cb6986811" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_31c821b7-76b6-4094-a67c-e9f90f255234" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4d25f3-5938-4e2b-a8d7-8a6b74118acf" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_31c821b7-76b6-4094-a67c-e9f90f255234" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7e693c30-6c25-45ea-bb61-311a79fdb3b4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4a4d25f3-5938-4e2b-a8d7-8a6b74118acf" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7e693c30-6c25-45ea-bb61-311a79fdb3b4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_6488ef06-570b-4a1f-99de-c986be1b10ad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7e693c30-6c25-45ea-bb61-311a79fdb3b4" xlink:to="loc_us-gaap_AwardTypeAxis_6488ef06-570b-4a1f-99de-c986be1b10ad" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_6488ef06-570b-4a1f-99de-c986be1b10ad_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_6488ef06-570b-4a1f-99de-c986be1b10ad" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_6488ef06-570b-4a1f-99de-c986be1b10ad_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_19abec3b-5acf-4f78-8458-bd74fb2c6d4f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_6488ef06-570b-4a1f-99de-c986be1b10ad" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_19abec3b-5acf-4f78-8458-bd74fb2c6d4f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember_fa547d95-611b-44ba-a0ab-95423243bab1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_19abec3b-5acf-4f78-8458-bd74fb2c6d4f" xlink:to="loc_us-gaap_EmployeeStockMember_fa547d95-611b-44ba-a0ab-95423243bab1" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_4cb57425-9e93-419c-b803-25d6f7c2e7a2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7e693c30-6c25-45ea-bb61-311a79fdb3b4" xlink:to="loc_us-gaap_PlanNameAxis_4cb57425-9e93-419c-b803-25d6f7c2e7a2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_4cb57425-9e93-419c-b803-25d6f7c2e7a2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_4cb57425-9e93-419c-b803-25d6f7c2e7a2" xlink:to="loc_us-gaap_PlanNameDomain_4cb57425-9e93-419c-b803-25d6f7c2e7a2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_9a630e40-e878-4f50-887a-ec2b86f4962e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_4cb57425-9e93-419c-b803-25d6f7c2e7a2" xlink:to="loc_us-gaap_PlanNameDomain_9a630e40-e878-4f50-887a-ec2b86f4962e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_A2017NonqualifiedEmployeeStockPurchasePlanMember_d38843fc-71da-4b73-aaf7-9834edbeb825" xlink:href="calx-20221231.xsd#calx_A2017NonqualifiedEmployeeStockPurchasePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_9a630e40-e878-4f50-887a-ec2b86f4962e" xlink:to="loc_calx_A2017NonqualifiedEmployeeStockPurchasePlanMember_d38843fc-71da-4b73-aaf7-9834edbeb825" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_EmployeeStockPurchasePlanMember_5ccd714f-0533-4b4f-807b-59d58f56f7d1" xlink:href="calx-20221231.xsd#calx_EmployeeStockPurchasePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_9a630e40-e878-4f50-887a-ec2b86f4962e" xlink:to="loc_calx_EmployeeStockPurchasePlanMember_5ccd714f-0533-4b4f-807b-59d58f56f7d1" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/StockholdersEquityAssumptionsDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#StockholdersEquityAssumptionsDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/StockholdersEquityAssumptionsDetails" xlink:type="extended" id="i294e07fd212542cfbe06ecbcaa97656d_StockholdersEquityAssumptionsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3beca203-e52e-473e-82bf-b766ded95b63" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_52da0c52-1c88-4012-ad5b-c309997674da" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3beca203-e52e-473e-82bf-b766ded95b63" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_52da0c52-1c88-4012-ad5b-c309997674da" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_dc3c7722-8df0-4627-a30a-3180357d1eb1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_52da0c52-1c88-4012-ad5b-c309997674da" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_dc3c7722-8df0-4627-a30a-3180357d1eb1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_9d5a8286-d005-452c-8a43-accaff3d52ce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_52da0c52-1c88-4012-ad5b-c309997674da" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_9d5a8286-d005-452c-8a43-accaff3d52ce" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_638fc76f-f273-4f01-89d0-13d0f279aff1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_52da0c52-1c88-4012-ad5b-c309997674da" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_638fc76f-f273-4f01-89d0-13d0f279aff1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4062d51f-284b-4630-84f0-d0b3e5dc5cff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3beca203-e52e-473e-82bf-b766ded95b63" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4062d51f-284b-4630-84f0-d0b3e5dc5cff" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_08862624-9758-4c55-b7a1-b278d41f3a2a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4062d51f-284b-4630-84f0-d0b3e5dc5cff" xlink:to="loc_us-gaap_AwardTypeAxis_08862624-9758-4c55-b7a1-b278d41f3a2a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_08862624-9758-4c55-b7a1-b278d41f3a2a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_08862624-9758-4c55-b7a1-b278d41f3a2a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_08862624-9758-4c55-b7a1-b278d41f3a2a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_8014f82b-429f-4bcf-a6e3-26c39e38ed02" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_08862624-9758-4c55-b7a1-b278d41f3a2a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_8014f82b-429f-4bcf-a6e3-26c39e38ed02" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_4fac624d-8e02-47ed-a58c-7834eb926783" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_8014f82b-429f-4bcf-a6e3-26c39e38ed02" xlink:to="loc_us-gaap_EmployeeStockOptionMember_4fac624d-8e02-47ed-a58c-7834eb926783" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember_5dbf485e-9a1d-4b62-8b37-7bd013ed8dcf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_8014f82b-429f-4bcf-a6e3-26c39e38ed02" xlink:to="loc_us-gaap_EmployeeStockMember_5dbf485e-9a1d-4b62-8b37-7bd013ed8dcf" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/StockholdersEquityUnrecognizedStockbasedCompensationExpensesDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#StockholdersEquityUnrecognizedStockbasedCompensationExpensesDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/StockholdersEquityUnrecognizedStockbasedCompensationExpensesDetails" xlink:type="extended" id="ie6044af20c024eea89f2ab54751b61ad_StockholdersEquityUnrecognizedStockbasedCompensationExpensesDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_950e2a0b-b48f-4df1-af0c-1878e1d3fb6a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_ccc6af91-beb2-494f-8cff-bf79743f9375" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_950e2a0b-b48f-4df1-af0c-1878e1d3fb6a" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_ccc6af91-beb2-494f-8cff-bf79743f9375" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_927d5003-dc8f-4395-b385-7efe502ea4ef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_950e2a0b-b48f-4df1-af0c-1878e1d3fb6a" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_927d5003-dc8f-4395-b385-7efe502ea4ef" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_EmployeeServiceSharebasedCompensationNonvestedAwardsCompensationCostNotyetRecognizedToBeRecognizedNextTwelveMonth_3e78f6d6-5d19-46fd-97b9-ddc5fc08f89e" xlink:href="calx-20221231.xsd#calx_EmployeeServiceSharebasedCompensationNonvestedAwardsCompensationCostNotyetRecognizedToBeRecognizedNextTwelveMonth"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_950e2a0b-b48f-4df1-af0c-1878e1d3fb6a" xlink:to="loc_calx_EmployeeServiceSharebasedCompensationNonvestedAwardsCompensationCostNotyetRecognizedToBeRecognizedNextTwelveMonth_3e78f6d6-5d19-46fd-97b9-ddc5fc08f89e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_EmployeeServiceSharebasedCompensationNonvestedAwardsCompensationCostNotyetRecognizedToBeRecognizedInYearTwo_25095cbf-f11a-461d-80c5-fb7379f5dbd5" xlink:href="calx-20221231.xsd#calx_EmployeeServiceSharebasedCompensationNonvestedAwardsCompensationCostNotyetRecognizedToBeRecognizedInYearTwo"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_950e2a0b-b48f-4df1-af0c-1878e1d3fb6a" xlink:to="loc_calx_EmployeeServiceSharebasedCompensationNonvestedAwardsCompensationCostNotyetRecognizedToBeRecognizedInYearTwo_25095cbf-f11a-461d-80c5-fb7379f5dbd5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_EmployeeServiceSharebasedCompensationNonvestedAwardsCompensationCostNotyetRecognizedToBeRecognizedInYearThree_ce4d36df-b9a7-4064-ad55-9757079a1674" xlink:href="calx-20221231.xsd#calx_EmployeeServiceSharebasedCompensationNonvestedAwardsCompensationCostNotyetRecognizedToBeRecognizedInYearThree"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_950e2a0b-b48f-4df1-af0c-1878e1d3fb6a" xlink:to="loc_calx_EmployeeServiceSharebasedCompensationNonvestedAwardsCompensationCostNotyetRecognizedToBeRecognizedInYearThree_ce4d36df-b9a7-4064-ad55-9757079a1674" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_EmployeeServiceSharebasedCompensationNonvestedAwardsCompensationCostNotyetRecognizedToBeRecognizedInYearFour_d229a3a9-a235-43ee-a4ef-0a918175922e" xlink:href="calx-20221231.xsd#calx_EmployeeServiceSharebasedCompensationNonvestedAwardsCompensationCostNotyetRecognizedToBeRecognizedInYearFour"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_950e2a0b-b48f-4df1-af0c-1878e1d3fb6a" xlink:to="loc_calx_EmployeeServiceSharebasedCompensationNonvestedAwardsCompensationCostNotyetRecognizedToBeRecognizedInYearFour_d229a3a9-a235-43ee-a4ef-0a918175922e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2c6ccdc9-52ba-431d-9947-6a88edf95afb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_950e2a0b-b48f-4df1-af0c-1878e1d3fb6a" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2c6ccdc9-52ba-431d-9947-6a88edf95afb" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_9aca22a0-8243-4d85-942b-406770496483" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_2c6ccdc9-52ba-431d-9947-6a88edf95afb" xlink:to="loc_us-gaap_AwardTypeAxis_9aca22a0-8243-4d85-942b-406770496483" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_9aca22a0-8243-4d85-942b-406770496483_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_9aca22a0-8243-4d85-942b-406770496483" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_9aca22a0-8243-4d85-942b-406770496483_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3e9b0ec6-8bd9-4aa9-8498-d5ac99edba9f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_9aca22a0-8243-4d85-942b-406770496483" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3e9b0ec6-8bd9-4aa9-8498-d5ac99edba9f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_5a2ab5a7-e0a6-4e11-a7a5-d700dc19acb7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3e9b0ec6-8bd9-4aa9-8498-d5ac99edba9f" xlink:to="loc_us-gaap_EmployeeStockOptionMember_5a2ab5a7-e0a6-4e11-a7a5-d700dc19acb7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember_ab26222b-dbfa-43f3-8aa9-504ee72e0da3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3e9b0ec6-8bd9-4aa9-8498-d5ac99edba9f" xlink:to="loc_us-gaap_EmployeeStockMember_ab26222b-dbfa-43f3-8aa9-504ee72e0da3" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/StockholdersEquitySharesReservedForFutureIssuanceDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#StockholdersEquitySharesReservedForFutureIssuanceDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/StockholdersEquitySharesReservedForFutureIssuanceDetails" xlink:type="extended" id="i785adf74073b4393a19ec84a66ddde74_StockholdersEquitySharesReservedForFutureIssuanceDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c22150-fa92-44e4-8b96-4d4e635d709d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_fca89cfb-861b-45c9-89a2-ffaf81d039db" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c22150-fa92-44e4-8b96-4d4e635d709d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_fca89cfb-861b-45c9-89a2-ffaf81d039db" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_1ee270f2-ccd2-4025-ba93-95f7f993767b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c22150-fa92-44e4-8b96-4d4e635d709d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_1ee270f2-ccd2-4025-ba93-95f7f993767b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_d9d1ef82-3038-4ef2-83fd-c5ec351d8c42" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c22150-fa92-44e4-8b96-4d4e635d709d" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_d9d1ef82-3038-4ef2-83fd-c5ec351d8c42" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_65cfca83-1e2b-4ab4-89d1-e3729b1779a7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_88c22150-fa92-44e4-8b96-4d4e635d709d" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_65cfca83-1e2b-4ab4-89d1-e3729b1779a7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_28390eac-b61d-416a-be52-7eeb34a8ac91" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_65cfca83-1e2b-4ab4-89d1-e3729b1779a7" xlink:to="loc_us-gaap_PlanNameAxis_28390eac-b61d-416a-be52-7eeb34a8ac91" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_28390eac-b61d-416a-be52-7eeb34a8ac91_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_28390eac-b61d-416a-be52-7eeb34a8ac91" xlink:to="loc_us-gaap_PlanNameDomain_28390eac-b61d-416a-be52-7eeb34a8ac91_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_ab9835e7-8be8-441e-8f0d-3cc2ed17cb2d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_28390eac-b61d-416a-be52-7eeb34a8ac91" xlink:to="loc_us-gaap_PlanNameDomain_ab9835e7-8be8-441e-8f0d-3cc2ed17cb2d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_A2019PlanMember_cb4a30a1-9778-434e-942f-2f0797a806d6" xlink:href="calx-20221231.xsd#calx_A2019PlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_ab9835e7-8be8-441e-8f0d-3cc2ed17cb2d" xlink:to="loc_calx_A2019PlanMember_cb4a30a1-9778-434e-942f-2f0797a806d6" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_A2017NonqualifiedEmployeeStockPurchasePlanMember_3aca9807-f62e-4df9-8959-91afb2afdca4" xlink:href="calx-20221231.xsd#calx_A2017NonqualifiedEmployeeStockPurchasePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_ab9835e7-8be8-441e-8f0d-3cc2ed17cb2d" xlink:to="loc_calx_A2017NonqualifiedEmployeeStockPurchasePlanMember_3aca9807-f62e-4df9-8959-91afb2afdca4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_5f1f63f8-7101-492e-be75-e8c4e57f2e1e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_65cfca83-1e2b-4ab4-89d1-e3729b1779a7" xlink:to="loc_us-gaap_AwardTypeAxis_5f1f63f8-7101-492e-be75-e8c4e57f2e1e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_5f1f63f8-7101-492e-be75-e8c4e57f2e1e_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_5f1f63f8-7101-492e-be75-e8c4e57f2e1e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_5f1f63f8-7101-492e-be75-e8c4e57f2e1e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_586cce2d-0d29-4395-abcf-3be523142c82" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_5f1f63f8-7101-492e-be75-e8c4e57f2e1e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_586cce2d-0d29-4395-abcf-3be523142c82" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember_25c2eec6-ae7b-4593-ae1c-c925be84b7f6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_586cce2d-0d29-4395-abcf-3be523142c82" xlink:to="loc_us-gaap_EmployeeStockMember_25c2eec6-ae7b-4593-ae1c-c925be84b7f6" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/AccumulatedOtherComprehensiveLossDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#AccumulatedOtherComprehensiveLossDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/AccumulatedOtherComprehensiveLossDetails" xlink:type="extended" id="ibf9b1527caf84758be0b789cf2aa65d2_AccumulatedOtherComprehensiveLossDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_3e3dd8d0-6d10-473a-b122-b42887d6b42d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1b8734ae-cd0d-4aed-918b-3434010729c3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_3e3dd8d0-6d10-473a-b122-b42887d6b42d" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1b8734ae-cd0d-4aed-918b-3434010729c3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_14215e48-2cd0-4bab-b3fa-405f9dcb729c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1b8734ae-cd0d-4aed-918b-3434010729c3" xlink:to="loc_us-gaap_StockholdersEquity_14215e48-2cd0-4bab-b3fa-405f9dcb729c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_611c1092-6c09-4bf9-9f60-7ce2df86f9b0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_1b8734ae-cd0d-4aed-918b-3434010729c3" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_611c1092-6c09-4bf9-9f60-7ce2df86f9b0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_3ccd1d8c-85f7-44d8-a31e-27c85df767e9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_9ecb89bf-1c49-4abd-a644-3c2a8d579d3e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossLineItems_3e3dd8d0-6d10-473a-b122-b42887d6b42d" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_9ecb89bf-1c49-4abd-a644-3c2a8d579d3e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_3c259938-7ccd-459b-adc0-934aba2c1d08" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossTable_9ecb89bf-1c49-4abd-a644-3c2a8d579d3e" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_3c259938-7ccd-459b-adc0-934aba2c1d08" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_3c259938-7ccd-459b-adc0-934aba2c1d08_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_3c259938-7ccd-459b-adc0-934aba2c1d08" xlink:to="loc_us-gaap_EquityComponentDomain_3c259938-7ccd-459b-adc0-934aba2c1d08_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_acb2e356-73c1-4863-b9b3-e97889e7f487" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_3c259938-7ccd-459b-adc0-934aba2c1d08" xlink:to="loc_us-gaap_EquityComponentDomain_acb2e356-73c1-4863-b9b3-e97889e7f487" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_f2fc7996-2e42-4d61-a643-fe51be38e53f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_acb2e356-73c1-4863-b9b3-e97889e7f487" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_f2fc7996-2e42-4d61-a643-fe51be38e53f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_023d64c2-fe08-4c62-b7aa-943b1d5faaa3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_f2fc7996-2e42-4d61-a643-fe51be38e53f" xlink:to="loc_us-gaap_AccumulatedNetUnrealizedInvestmentGainLossMember_023d64c2-fe08-4c62-b7aa-943b1d5faaa3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_3295b896-0ab4-4793-bec1-8afbcdf35f93" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedTranslationAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_f2fc7996-2e42-4d61-a643-fe51be38e53f" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_3295b896-0ab4-4793-bec1-8afbcdf35f93" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/IncomeTaxesTextualDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#IncomeTaxesTextualDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/IncomeTaxesTextualDetails" xlink:type="extended" id="if4c5dffd4b2e44a2b47fb72fb50979c8_IncomeTaxesTextualDetails">
    <link:loc xlink:type="locator" xlink:label="loc_calx_IncomeTaxesLineItems_a35515bd-e330-4d9a-ad05-126f526030df" xlink:href="calx-20221231.xsd#calx_IncomeTaxesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_63b32cee-31b8-48da-9cc5-84a5729be205" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_calx_IncomeTaxesLineItems_a35515bd-e330-4d9a-ad05-126f526030df" xlink:to="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_63b32cee-31b8-48da-9cc5-84a5729be205" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_eb776b21-0209-4c81-b21d-579db9b5b7a4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_calx_IncomeTaxesLineItems_a35515bd-e330-4d9a-ad05-126f526030df" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_eb776b21-0209-4c81-b21d-579db9b5b7a4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwards_c460a0d7-f3d1-4825-9c6f-a72156e51e40" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLossCarryforwards"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_calx_IncomeTaxesLineItems_a35515bd-e330-4d9a-ad05-126f526030df" xlink:to="loc_us-gaap_OperatingLossCarryforwards_c460a0d7-f3d1-4825-9c6f-a72156e51e40" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardAmount_e3f74dcf-a51c-4d2a-9ad0-a84e16fd35ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TaxCreditCarryforwardAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_calx_IncomeTaxesLineItems_a35515bd-e330-4d9a-ad05-126f526030df" xlink:to="loc_us-gaap_TaxCreditCarryforwardAmount_e3f74dcf-a51c-4d2a-9ad0-a84e16fd35ec" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefits_9edd8273-45ba-4c41-bf5e-8982197d67f8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnrecognizedTaxBenefits"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_calx_IncomeTaxesLineItems_a35515bd-e330-4d9a-ad05-126f526030df" xlink:to="loc_us-gaap_UnrecognizedTaxBenefits_9edd8273-45ba-4c41-bf5e-8982197d67f8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate_bd5ee275-0d70-435a-a888-8e5d3cb6b81f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_calx_IncomeTaxesLineItems_a35515bd-e330-4d9a-ad05-126f526030df" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate_bd5ee275-0d70-435a-a888-8e5d3cb6b81f" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestAccrued_e3c598ae-87dd-448e-8968-01e52dad6eab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestAccrued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_calx_IncomeTaxesLineItems_a35515bd-e330-4d9a-ad05-126f526030df" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestAccrued_e3c598ae-87dd-448e-8968-01e52dad6eab" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_IncomeTaxesTable_56d08dab-70f2-4965-a5c9-f387c597f2e4" xlink:href="calx-20221231.xsd#calx_IncomeTaxesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_calx_IncomeTaxesLineItems_a35515bd-e330-4d9a-ad05-126f526030df" xlink:to="loc_calx_IncomeTaxesTable_56d08dab-70f2-4965-a5c9-f387c597f2e4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_63aca7c2-a07a-4e4c-9e9e-e9de2222770b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_calx_IncomeTaxesTable_56d08dab-70f2-4965-a5c9-f387c597f2e4" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_63aca7c2-a07a-4e4c-9e9e-e9de2222770b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_63aca7c2-a07a-4e4c-9e9e-e9de2222770b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_63aca7c2-a07a-4e4c-9e9e-e9de2222770b" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_63aca7c2-a07a-4e4c-9e9e-e9de2222770b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_a6c995af-a2e5-449e-bc24-1be471cc2745" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_63aca7c2-a07a-4e4c-9e9e-e9de2222770b" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_a6c995af-a2e5-449e-bc24-1be471cc2745" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DomesticCountryMember_c08b8459-74db-4fba-a48a-aad8585bdb6f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DomesticCountryMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_a6c995af-a2e5-449e-bc24-1be471cc2745" xlink:to="loc_us-gaap_DomesticCountryMember_c08b8459-74db-4fba-a48a-aad8585bdb6f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StateAndLocalJurisdictionMember_82cc1767-6131-4ee2-ba65-50d9f56dfd04" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StateAndLocalJurisdictionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_a6c995af-a2e5-449e-bc24-1be471cc2745" xlink:to="loc_us-gaap_StateAndLocalJurisdictionMember_82cc1767-6131-4ee2-ba65-50d9f56dfd04" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_CaliforniaStateMember_c1fe1cb5-4ac0-4357-a289-18373795b60e" xlink:href="calx-20221231.xsd#calx_CaliforniaStateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_a6c995af-a2e5-449e-bc24-1be471cc2745" xlink:to="loc_calx_CaliforniaStateMember_c1fe1cb5-4ac0-4357-a289-18373795b60e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_OtherStateMember_d5a9c1bf-c9ca-4b30-8519-3741f877c203" xlink:href="calx-20221231.xsd#calx_OtherStateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_a6c995af-a2e5-449e-bc24-1be471cc2745" xlink:to="loc_calx_OtherStateMember_d5a9c1bf-c9ca-4b30-8519-3741f877c203" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/RevenuefromContractswithCustomersRevenuebyGeographicRegionDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#RevenuefromContractswithCustomersRevenuebyGeographicRegionDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/RevenuefromContractswithCustomersRevenuebyGeographicRegionDetails" xlink:type="extended" id="i590ecf9596e04ce096921bf5c4219031_RevenuefromContractswithCustomersRevenuebyGeographicRegionDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_ab57f09f-c596-488f-b9b3-4f97de2ddc0d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_28767dcf-78c9-4c70-8e6b-22d6d956b8fb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_ab57f09f-c596-488f-b9b3-4f97de2ddc0d" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_28767dcf-78c9-4c70-8e6b-22d6d956b8fb" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_1bd658e2-b251-441b-b577-36028f68f4b7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_ab57f09f-c596-488f-b9b3-4f97de2ddc0d" xlink:to="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_1bd658e2-b251-441b-b577-36028f68f4b7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_dfb71a81-afdf-46c0-8071-c492fd4a9421" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_1bd658e2-b251-441b-b577-36028f68f4b7" xlink:to="loc_srt_StatementGeographicalAxis_dfb71a81-afdf-46c0-8071-c492fd4a9421" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_dfb71a81-afdf-46c0-8071-c492fd4a9421_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_dfb71a81-afdf-46c0-8071-c492fd4a9421" xlink:to="loc_srt_SegmentGeographicalDomain_dfb71a81-afdf-46c0-8071-c492fd4a9421_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_b9e9d92e-2b03-41d0-a3c0-36a4e4e7b947" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_dfb71a81-afdf-46c0-8071-c492fd4a9421" xlink:to="loc_srt_SegmentGeographicalDomain_b9e9d92e-2b03-41d0-a3c0-36a4e4e7b947" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_f3e88d35-995b-4bcd-a6eb-805adb016e80" xlink:href="https://xbrl.sec.gov/country/2022/country-2022.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_b9e9d92e-2b03-41d0-a3c0-36a4e4e7b947" xlink:to="loc_country_US_f3e88d35-995b-4bcd-a6eb-805adb016e80" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EuropeMember_d9ea8b21-fb81-4e79-aae3-119c88872cee" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_EuropeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_b9e9d92e-2b03-41d0-a3c0-36a4e4e7b947" xlink:to="loc_srt_EuropeMember_d9ea8b21-fb81-4e79-aae3-119c88872cee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_AmericasExUSMember_c557d7c0-efe0-4edf-a8b9-7b2d1d1ba7bd" xlink:href="calx-20221231.xsd#calx_AmericasExUSMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_b9e9d92e-2b03-41d0-a3c0-36a4e4e7b947" xlink:to="loc_calx_AmericasExUSMember_c557d7c0-efe0-4edf-a8b9-7b2d1d1ba7bd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_MiddleEastAndAfricaMember_dad55d25-e722-45b6-af5e-06efb2ec9be0" xlink:href="calx-20221231.xsd#calx_MiddleEastAndAfricaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_b9e9d92e-2b03-41d0-a3c0-36a4e4e7b947" xlink:to="loc_calx_MiddleEastAndAfricaMember_dad55d25-e722-45b6-af5e-06efb2ec9be0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_AsiaPacificMember_a34394ee-7f6b-4c4c-bfc1-91f9d9b82deb" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_AsiaPacificMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_b9e9d92e-2b03-41d0-a3c0-36a4e4e7b947" xlink:to="loc_srt_AsiaPacificMember_a34394ee-7f6b-4c4c-bfc1-91f9d9b82deb" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/RevenuefromContractswithCustomersPropertyandEquipmentbyGeographicRegionDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#RevenuefromContractswithCustomersPropertyandEquipmentbyGeographicRegionDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/RevenuefromContractswithCustomersPropertyandEquipmentbyGeographicRegionDetails" xlink:type="extended" id="ic144524b10a8479e9debf1705de02d41_RevenuefromContractswithCustomersPropertyandEquipmentbyGeographicRegionDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_63425276-f6c8-46a8-8035-e63b9981a10d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_76ba99d1-b313-4359-a111-7d595429dbdf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_63425276-f6c8-46a8-8035-e63b9981a10d" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_76ba99d1-b313-4359-a111-7d595429dbdf" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_bed4298c-19b0-4853-9445-499e1bef256a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_63425276-f6c8-46a8-8035-e63b9981a10d" xlink:to="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_bed4298c-19b0-4853-9445-499e1bef256a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_b021677a-8a99-4c18-a8a7-47e8e4aba36c" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_bed4298c-19b0-4853-9445-499e1bef256a" xlink:to="loc_srt_StatementGeographicalAxis_b021677a-8a99-4c18-a8a7-47e8e4aba36c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_b021677a-8a99-4c18-a8a7-47e8e4aba36c_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_b021677a-8a99-4c18-a8a7-47e8e4aba36c" xlink:to="loc_srt_SegmentGeographicalDomain_b021677a-8a99-4c18-a8a7-47e8e4aba36c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_3568af99-8ccd-4d1f-9669-e0836ad7fc80" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_b021677a-8a99-4c18-a8a7-47e8e4aba36c" xlink:to="loc_srt_SegmentGeographicalDomain_3568af99-8ccd-4d1f-9669-e0836ad7fc80" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_aa60f9ad-c86f-44d9-9561-667958b4280a" xlink:href="https://xbrl.sec.gov/country/2022/country-2022.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_3568af99-8ccd-4d1f-9669-e0836ad7fc80" xlink:to="loc_country_US_aa60f9ad-c86f-44d9-9561-667958b4280a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_CN_f3f15190-9ea8-4b1f-999c-e0e10b565d5c" xlink:href="https://xbrl.sec.gov/country/2022/country-2022.xsd#country_CN"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_3568af99-8ccd-4d1f-9669-e0836ad7fc80" xlink:to="loc_country_CN_f3f15190-9ea8-4b1f-999c-e0e10b565d5c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_IN_86b934ab-917b-4940-a645-e0a9a38412c6" xlink:href="https://xbrl.sec.gov/country/2022/country-2022.xsd#country_IN"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_3568af99-8ccd-4d1f-9669-e0836ad7fc80" xlink:to="loc_country_IN_86b934ab-917b-4940-a645-e0a9a38412c6" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/RevenuefromContractswithCustomersPerformanceObligationDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#RevenuefromContractswithCustomersPerformanceObligationDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/RevenuefromContractswithCustomersPerformanceObligationDetails" xlink:type="extended" id="icdd3388577f1418caf250650d8411c43_RevenuefromContractswithCustomersPerformanceObligationDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_1098f399-8948-4b12-949c-22e1e235c76d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationPercentage_fe54ef58-8934-4bbf-b375-6311cba0d889" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_1098f399-8948-4b12-949c-22e1e235c76d" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationPercentage_fe54ef58-8934-4bbf-b375-6311cba0d889" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_be07473f-f84b-490c-adcb-ee0795220a56" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_1098f399-8948-4b12-949c-22e1e235c76d" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_be07473f-f84b-490c-adcb-ee0795220a56" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_9648c4eb-6524-45ce-a9e4-aabab3687f1a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_1098f399-8948-4b12-949c-22e1e235c76d" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_9648c4eb-6524-45ce-a9e4-aabab3687f1a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionStartDateAxis_041e0232-cc67-49d3-aa79-172d07f418cd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionStartDateAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_9648c4eb-6524-45ce-a9e4-aabab3687f1a" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionStartDateAxis_041e0232-cc67-49d3-aa79-172d07f418cd" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/RevenuefromContractswithCustomersPerformanceObligationDetails_1" xlink:type="simple" xlink:href="calx-20221231.xsd#RevenuefromContractswithCustomersPerformanceObligationDetails_1"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/RevenuefromContractswithCustomersPerformanceObligationDetails_1" xlink:type="extended" id="i04dbf7e644e343fcbbf64cb4a658f31c_RevenuefromContractswithCustomersPerformanceObligationDetails_1">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_1098f399-8948-4b12-949c-22e1e235c76d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationPercentage_fe54ef58-8934-4bbf-b375-6311cba0d889" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_1098f399-8948-4b12-949c-22e1e235c76d" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationPercentage_fe54ef58-8934-4bbf-b375-6311cba0d889" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_be07473f-f84b-490c-adcb-ee0795220a56" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_1098f399-8948-4b12-949c-22e1e235c76d" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionPeriod1_be07473f-f84b-490c-adcb-ee0795220a56" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_9648c4eb-6524-45ce-a9e4-aabab3687f1a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionLineItems_1098f399-8948-4b12-949c-22e1e235c76d" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligationExpectedTimingOfSatisfactionTable_9648c4eb-6524-45ce-a9e4-aabab3687f1a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.calix.com/role/RevenuefromContractswithCustomersConcentrationRiskDetails" xlink:type="simple" xlink:href="calx-20221231.xsd#RevenuefromContractswithCustomersConcentrationRiskDetails"/>
  <link:definitionLink xlink:role="http://www.calix.com/role/RevenuefromContractswithCustomersConcentrationRiskDetails" xlink:type="extended" id="i74c72bea841845ba97091e7de64c95f9_RevenuefromContractswithCustomersConcentrationRiskDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskLineItems_7f3938ed-46a9-4d6f-a944-64d5b3fd627d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_07f5dd68-87ad-4858-b471-f46145a08c7f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_7f3938ed-46a9-4d6f-a944-64d5b3fd627d" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_07f5dd68-87ad-4858-b471-f46145a08c7f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTable_3ea3c5e4-12ee-43fa-8336-a06366d743fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_7f3938ed-46a9-4d6f-a944-64d5b3fd627d" xlink:to="loc_us-gaap_ConcentrationRiskTable_3ea3c5e4-12ee-43fa-8336-a06366d743fd" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MajorCustomersAxis_b1eb8b3a-66f6-49b9-b0db-c04aa62e06b6" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MajorCustomersAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_3ea3c5e4-12ee-43fa-8336-a06366d743fd" xlink:to="loc_srt_MajorCustomersAxis_b1eb8b3a-66f6-49b9-b0db-c04aa62e06b6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_b1eb8b3a-66f6-49b9-b0db-c04aa62e06b6_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_MajorCustomersAxis_b1eb8b3a-66f6-49b9-b0db-c04aa62e06b6" xlink:to="loc_srt_NameOfMajorCustomerDomain_b1eb8b3a-66f6-49b9-b0db-c04aa62e06b6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_8e51a0fb-4847-4dda-ad3f-f09be5d8d895" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_MajorCustomersAxis_b1eb8b3a-66f6-49b9-b0db-c04aa62e06b6" xlink:to="loc_srt_NameOfMajorCustomerDomain_8e51a0fb-4847-4dda-ad3f-f09be5d8d895" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_LumenTechnologiesIncMember_202c5d02-bd51-4c1e-903d-7a6f47e66eff" xlink:href="calx-20221231.xsd#calx_LumenTechnologiesIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_8e51a0fb-4847-4dda-ad3f-f09be5d8d895" xlink:to="loc_calx_LumenTechnologiesIncMember_202c5d02-bd51-4c1e-903d-7a6f47e66eff" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_OneCustomerMember_b189e2cf-8077-4d69-b3a0-090a5878bfdd" xlink:href="calx-20221231.xsd#calx_OneCustomerMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_8e51a0fb-4847-4dda-ad3f-f09be5d8d895" xlink:to="loc_calx_OneCustomerMember_b189e2cf-8077-4d69-b3a0-090a5878bfdd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_calx_CustomerTwoMember_1c8383e7-6445-496e-8601-93c1ff7773b2" xlink:href="calx-20221231.xsd#calx_CustomerTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_8e51a0fb-4847-4dda-ad3f-f09be5d8d895" xlink:to="loc_calx_CustomerTwoMember_1c8383e7-6445-496e-8601-93c1ff7773b2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_fb87f3d8-7506-4021-ad64-0907c5bcd0c0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_3ea3c5e4-12ee-43fa-8336-a06366d743fd" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_fb87f3d8-7506-4021-ad64-0907c5bcd0c0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_fb87f3d8-7506-4021-ad64-0907c5bcd0c0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_fb87f3d8-7506-4021-ad64-0907c5bcd0c0" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_fb87f3d8-7506-4021-ad64-0907c5bcd0c0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_5ce577f2-59b6-4eb1-b1e9-92725775461d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_fb87f3d8-7506-4021-ad64-0907c5bcd0c0" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_5ce577f2-59b6-4eb1-b1e9-92725775461d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_d38567ed-384c-4c1d-89d5-2da40b968617" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CustomerConcentrationRiskMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_5ce577f2-59b6-4eb1-b1e9-92725775461d" xlink:to="loc_us-gaap_CustomerConcentrationRiskMember_d38567ed-384c-4c1d-89d5-2da40b968617" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_7fa3f0f8-2d0b-4b0b-b9ae-90b0c3a49fb3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ConcentrationRiskTable_3ea3c5e4-12ee-43fa-8336-a06366d743fd" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_7fa3f0f8-2d0b-4b0b-b9ae-90b0c3a49fb3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_7fa3f0f8-2d0b-4b0b-b9ae-90b0c3a49fb3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_7fa3f0f8-2d0b-4b0b-b9ae-90b0c3a49fb3" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_7fa3f0f8-2d0b-4b0b-b9ae-90b0c3a49fb3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_c64e56b3-fded-479d-a5a1-4dc5a2a55450" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_7fa3f0f8-2d0b-4b0b-b9ae-90b0c3a49fb3" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_c64e56b3-fded-479d-a5a1-4dc5a2a55450" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerMember_584df4b0-3044-4cce-b0d1-5225fa0a619c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_c64e56b3-fded-479d-a5a1-4dc5a2a55450" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerMember_584df4b0-3044-4cce-b0d1-5225fa0a619c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableMember_37c78c90-058d-48fe-a639-6be9672d9a30" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_c64e56b3-fded-479d-a5a1-4dc5a2a55450" xlink:to="loc_us-gaap_AccountsReceivableMember_37c78c90-058d-48fe-a639-6be9672d9a30" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://fasb.org/us-gaap/role/eedm/ExtensibleEnumerationLists" xlink:type="simple" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-roles-2022.xsd#eedm"/>
  <link:definitionLink xlink:role="http://fasb.org/us-gaap/role/eedm/ExtensibleEnumerationLists" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent" xlink:type="arc" order="1"/>
  </link:definitionLink>
</link:linkbase>
