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Amgen license agreement (Details) - USD ($)	1 Months Ended		3 Months Ended		6 Months Ended
	Nov. 30, 2018	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Share Issued value under agreement					$ 95,453,000
Loss recognized related to change in fair value of the anti-dilution right liability prior to extinguishment				$ (11,000)		$ (11,000)
Research and development expense			$ 5,960,000	$ 8,420,000	10,023,000	8,646,000
Upfront cash payment						5,000,000
Fair value of issuance of the anti-dilution right liability						$ 1,639,000
Amgen Agreement
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Initial fair value of the anti-dilution right liability	$ 7,404,000
Amgen Agreement | Amgen
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Ownership interest of the outstanding shares (as a percent)		10.00%		10.00%		10.00%
Amgen Agreement | Research and Development Expense
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Initial fair value of the anti-dilution right liability		$ 1,639,000
Research and development expense				$ 7,992,000		$ 7,992,000
Upfront cash payment			5,000,000		5,000,000
Fair value of shares of Series A Preferred Stock issued to Amgen			1,353,000		1,353,000
Fair value of issuance of the anti-dilution right liability			$ 1,639,000		$ 1,639,000
Amgen Agreement | Other expense
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Loss recognized related to change in fair value of the anti-dilution right liability prior to extinguishment		11,000
Amgen Agreement | Amgen
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Upfront payment		5,000,000
Total consideration transferred to Amgen		$ 6,353,000
Amgen Agreement | Series A Preferred Stock
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Share Issued value under agreement	$ 3,205,128
Amgen Agreement | Series A Preferred Stock | Amgen
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Share Issued under agreement		2,653,333
Share Issued value under agreement		$ 1,353,000

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