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Amgen license agreement (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended
Aug. 31, 2019
Nov. 30, 2018
Jun. 30, 2018
Mar. 31, 2021
Mar. 31, 2020
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Research and development expense       $ 10,602 $ 8,791
Amgen Agreement          
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Initial fair value of the anti-dilution right liability   $ 7,404      
Payment for clinical trail $ 2,500        
Obligation for payment in connection with dosing of the first patient 7,500        
Amgen Agreement | Maximum          
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Aggregate milestone payments upon the achievement of specified commercial milestones 75,000        
Payment in connection with dosing of the first patient $ 30,000        
Amgen Agreement | Amgen          
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Ownership interest of the outstanding shares (as a percent)     10.00%    
Amgen Agreement | Research and development expense          
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Research and development expense       $ 0 $ 0
Amgen Agreement | Amgen          
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Upfront payment     $ 5,000    
Amgen Agreement | Series A Preferred Stock          
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Share Issued under agreement   3,205,128      
Amgen Agreement | Series A Preferred Stock | Amgen          
Research and Development Arrangement, Contract to Perform for Others [Line Items]          
Share Issued under agreement     2,653,333    
Share Issued value under agreement     $ 1,353