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Nature of the business and basis of presentation (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended 12 Months Ended
Sep. 30, 2021
Jun. 30, 2021
Mar. 31, 2021
Sep. 30, 2020
Jun. 30, 2020
Mar. 31, 2020
Sep. 30, 2021
Sep. 30, 2020
Dec. 31, 2020
Dec. 31, 2019
Nature of the business and basis of presentation                    
Net loss $ 24,330 $ 28,933 $ 15,090 $ 21,403 $ 16,207 $ 11,886 $ 68,353 $ 49,496 $ 79,207 $ 43,755
Accumulated deficit 277,880           277,880   $ 209,527  
Cash, cash equivalents and short-term marketable securities $ 215,081           $ 215,081