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Commitments and contingencies - Components of operating lease expense (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Sep. 30, 2021
Sep. 30, 2020
Operating lease expense:        
Total operating lease cost $ 81 $ 81 $ 243 $ 261
Other information:        
Cash paid for amounts included in the measurement of operating lease liability $ 76 $ 18 $ 226 $ 135
Weighted average remaining lease term, in years 5 years 9 months 18 days 6 years 9 months 18 days 5 years 9 months 18 days 6 years 9 months 18 days
Weighted average discount rate 7.60% 7.60% 7.60% 7.60%
General and administrative expense        
Operating lease expense:        
Operating lease cost $ 81 $ 73 $ 243 $ 186
Variable operating lease cost       43
Research and development expense        
Operating lease expense:        
Short-term lease cost   $ 8   $ 32