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Licenses and Collaborative Arrangement - Additional information (Details) ¥ in Millions, $ in Millions |  |  |  |  |  |  |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Dec. 19, 2017 USD ($) | Apr. 30, 2017 | Oct. 31, 2016 | Sep. 30, 2016 | Nov. 30, 2015 | Sep. 30, 2015 | Jul. 31, 2015 | Jan. 31, 2018 USD ($) | Mar. 31, 2015 | Dec. 31, 2017 USD ($) | Dec. 31, 2017 CNY (¥) | Dec. 31, 2016 USD ($) | Dec. 31, 2016 CNY (¥) | Dec. 31, 2015 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments |  |  |  |  |  |  |  |  |  | $ 0.3 |  |  |  |
Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Future milestone payments to be made upon achievement |  |  |  |  |  |  |  |  |  | 400.8 |  |  |  |
BMS |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreement date |  |  |  |  |  |  |  |  | 2015-03 |  |  |  |  |
Sanofi |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreement date |  |  |  |  |  |  | 2015-07 |  |  |  |  |  |  |
Upfront payments |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.5
License agreement, expiration period |  |  |  |  |  |  |  |  |  |  |  |  |  | 10 years
UCB |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreement date |  |  |  |  |  | 2015-09 |  |  |  |  |  |  |  |
Upfront payments |  |  |  |  |  |  |  |  |  |  |  | $ 0.8 |  |
License agreement, expiration period |  |  |  |  |  |  |  |  |  |  |  | 10 years | 10 years |
Hanmi |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreement date |  |  |  |  | 2015-11 |  |  |  |  |  |  |  |  |
Upfront payments |  |  |  |  |  |  |  |  |  |  |  | $ 1.0 |  | $ 6.0
License agreement, expiration period |  |  |  |  |  |  |  |  |  |  |  | 10 years | 10 years | 10 years
Tesaro |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreement date |  |  |  | 2016-09 |  |  |  |  |  |  |  |  |  |
Upfront payments |  |  |  |  |  |  |  |  |  |  |  | $ 15.0 |  |
License agreement, expiration period |  |  |  |  |  |  |  |  |  |  |  | 10 years | 10 years |
GSK China |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreement date |  |  | 2016-10 |  |  |  |  |  |  |  |  |  |  |
Upfront payments |  |  |  |  |  |  |  |  |  |  |  | $ 0.7 | ¥ 4.5 |
Bater |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments |  |  |  |  |  |  |  |  |  | 0.3 | ¥ 2.0 |  |  |
Paratek |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreement date |  | 2017-04 |  |  |  |  |  |  |  |  |  |  |  |
Upfront payments |  |  |  |  |  |  |  |  |  | $ 7.5 |  |  |  |
License agreement, expiration period |  |  |  |  |  |  |  |  |  | 11 years | 11 years |  |  |
Five Prime |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
License agreement date | Dec. 19, 2017 |  |  |  |  |  |  |  |  |  |  |  |  |
Future milestone payments to be made upon achievement | $ 39.0 |  |  |  |  |  |  |  |  |  |  |  |  |
Five Prime | Subsequent Event |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payment of upfront fees |  |  |  |  |  |  |  | $ 5.0 |  |  |  |  |  |

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