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v3.21.2

Consolidated statements of shareholders' equity - USD ($) $ in Thousands | Total | Ordinary Shares | Additional Paid In Capital | Accumulated Deficit | Accumulated Other Comprehensive (Loss) Income | Treasury Stock
--- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2019 | $ 294,660 | $ 4 | $ 734,734 | $ (444,698) | $ 4,620 |
Balance, Shares at Dec. 31, 2019 |  | 68,237,247 |  |  |  |
Issuance of ordinary shares upon vesting of restricted shares | 0 | $ 0 | 0 |  |  |
Issuance of ordinary shares upon vesting of restricted shares, Shares |  | 80,200 |  |  |  |
Exercise of shares option | 346 | $ 0 | 346 |  |  |
Exercise of shares option, Shares |  | 49,278 |  |  |  |
Issuance of ordinary shares upon follow-on public offering, net of issuance cost | 280,568 | $ 0 | 280,568 |  |  |
Issuance of ordinary shares upon follow-on public offering, net of issuance cost, Shares |  | 6,300,000 |  |  |  |
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs | (740) |  |  |  |  |
Share-based compensation | 6,463 |  | 6,463 |  |  |
Net loss | (47,988) |  |  | (47,988) |  |
Foreign currency translation | 3,539 |  |  |  | 3,539 |
Balance at Mar. 31, 2020 | 537,588 | $ 4 | 1,022,111 | (492,686) | 8,159 |
Balance, Shares at Mar. 31, 2020 |  | 74,666,725 |  |  |  |
Balance at Dec. 31, 2019 | 294,660 | $ 4 | 734,734 | (444,698) | 4,620 |
Balance, Shares at Dec. 31, 2019 |  | 68,237,247 |  |  |  |
Net loss | (128,617) |  |  |  |  |
Foreign currency translation | 2,366 |  |  |  |  |
Balance at Jun. 30, 2020 | 465,466 | $ 4 | 1,031,791 | (573,315) | 6,986 |
Balance, Shares at Jun. 30, 2020 |  | 74,882,338 |  |  |  |
Balance at Mar. 31, 2020 | 537,588 | $ 4 | 1,022,111 | (492,686) | 8,159 |
Balance, Shares at Mar. 31, 2020 |  | 74,666,725 |  |  |  |
Issuance of ordinary shares upon vesting of restricted shares | 0 | $ 0 | 0 |  |  |
Issuance of ordinary shares upon vesting of restricted shares, Shares |  | 36,000 |  |  |  |
Exercise of shares option | 2,729 | $ 0 | 2,729 |  |  |
Exercise of shares option, Shares |  | 179,613 |  |  |  |
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs | (13) |  | (13) |  |  |
Share-based compensation | 6,964 |  | 6,964 |  |  |
Net loss | (80,629) |  |  | (80,629) |  |
Foreign currency translation | (1,173) |  |  |  | (1,173) |
Balance at Jun. 30, 2020 | 465,466 | $ 4 | 1,031,791 | (573,315) | 6,986 |
Balance, Shares at Jun. 30, 2020 |  | 74,882,338 |  |  |  |
Balance at Dec. 31, 2020 | $ 1,169,345 | $ 5 | 1,897,467 | (713,603) | (14,524) |
Balance, Shares at Dec. 31, 2020 | 87,811,026 | 87,811,026 |  |  |  |
Issuance of ordinary shares upon vesting of restricted shares | $ 0 | $ 0 | 0 |  |  |
Issuance of ordinary shares upon vesting of restricted shares, Shares |  | 81,600 |  |  |  |
Exercise of shares option | 702 | $ 0 | 702 |  |  |
Exercise of shares option, Shares |  | 58,364 |  |  |  |
Issuance of ordinary shares in connection with collaboration and license arrangement | 62,250 | $ 0 | 62,250 |  |  |
Issuance of ordinary shares in connection with collaboration and license arrangement, Shares |  | 568,182 |  |  |  |
Issuance cost adjustment for secondary listing | 65 |  | 65 |  |  |
Share-based compensation | 7,318 |  | 7,318 |  |  |
Net loss | (232,910) |  |  | (232,910) |  |
Foreign currency translation | 2,900 |  |  |  | 2,900 |
Balance at Mar. 31, 2021 | 1,009,670 | $ 5 | 1,967,802 | (946,513) | (11,624) |
Balance, Shares at Mar. 31, 2021 |  | 88,519,172 |  |  |  |
Balance at Dec. 31, 2020 | $ 1,169,345 | $ 5 | 1,897,467 | (713,603) | (14,524) |
Balance, Shares at Dec. 31, 2020 | 87,811,026 | 87,811,026 |  |  |  |
Net loss | $ (396,234) |  |  |  |  |
Foreign currency translation | (2,341) |  |  |  |  |
Balance at Jun. 30, 2021 | $ 1,671,698 | $ 6 | 2,799,318 | (1,109,837) | (16,865) | $ (924)
Balance, Shares at Jun. 30, 2021 | 94,758,189 | 94,758,189 |  |  |  | (6,086)
Balance at Mar. 31, 2021 | $ 1,009,670 | $ 5 | 1,967,802 | (946,513) | (11,624) |
Balance, Shares at Mar. 31, 2021 |  | 88,519,172 |  |  |  |
Issuance of ordinary shares upon vesting of restricted shares | 0 | $ 0 | 0 |  |  |
Issuance of ordinary shares upon vesting of restricted shares, Shares |  | 32,100 |  |  |  |
Exercise of shares option | 3,289 | $ 0 | 3,289 |  |  |
Exercise of shares option, Shares |  | 490,517 |  |  |  |
Receipt of employees' shares to satisfy tax withholding obligations related to share-based compensation |  |  |  |  |  | (6,086)
Receipt of employees' shares to satisfy tax withholding obligations related to share-based compensation | (924) |  |  |  |  | $ (924)
Issuance of ordinary shares upon follow-on public offering, net of issuance cost | 817,996 | $ 1 | 817,995 |  |  |
Issuance of ordinary shares upon follow-on public offering, net of issuance cost, Shares |  | 5,716,400 |  |  |  |
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs | (879) |  |  |  |  |
Share-based compensation | 10,232 |  | 10,232 |  |  |
Net loss | (163,324) |  |  | (163,324) |  |
Foreign currency translation | (5,241) |  |  |  | (5,241) |
Balance at Jun. 30, 2021 | $ 1,671,698 | $ 6 | $ 2,799,318 | $ (1,109,837) | $ (16,865) | $ (924)
Balance, Shares at Jun. 30, 2021 | 94,758,189 | 94,758,189 |  |  |  | (6,086)

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