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Loss per share - Summary of Basic and Diluted Net Loss Per Share (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020
Numerator:
Net loss attributable to ordinary shareholders	$ (163,324)	$ (80,629)	$ (396,234)	$ (128,617)
Denominator:
Weighted average number of ordinary shares- basic and diluted	93,045,531	74,738,563	90,723,132	73,847,551
Product revenue -net	$ (1.76)	$ (1.08)	$ (4.37)	$ (1.74)

X

- Definition

The amount of net income or loss for the period per each share in instances when basic and diluted earnings per share are the same amount and reported as a single line item on the face of the financial statements. Basic earnings per share is the amount of net income or loss for the period per each share of common stock or unit outstanding during the reporting period. Diluted earnings per share includes the amount of net income or loss for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.

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Amount, after deduction of tax, noncontrolling interests, dividends on preferred stock and participating securities; of income (loss) available to common shareholders.

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Average number of shares or units issued and outstanding that are used in calculating basic and diluted earnings per share (EPS).

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