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Consolidated statements of cash flows - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2021
Jun. 30, 2020
Operating activities    
Net loss $ (396,234) $ (128,617)
Adjustments to reconcile net loss to net cash used in operating activities:    
Allowance for doubtful accounts 4 2
Inventory write-down 290 7
Depreciation and amortization expenses 2,975 2,107
Amortization of deferred income (156) (156)
Share-based compensation 17,550 13,427
Noncash research and development expenses 62,250  
Share of loss from equity method investment 208 406
Loss on disposal of property and equipment 4 1
Noncash lease expenses 2,779 2,114
Changes in operating assets and liabilities:    
Accounts receivable (12,868) (3,235)
Inventories 1,740 (571)
Prepayments and other current assets (1,952) (948)
Long term deposits (29) (335)
Value added tax recoverable (1,682) (2,422)
Accounts payable 62,980 9,732
Other current liabilities 28,077 4,697
Operating lease liabilities (2,214) (1,539)
Deferred income 930 13,011
Net cash used in operating activities (235,348) (92,319)
Cash flows from investing activities:    
Purchases of short-term investments   (205,000)
Proceeds from maturity of short-term investments 743,902 200,000
Purchase of property and equipment (5,647) (1,303)
Purchase of intangible assets (427) (218)
Net cash provided by (used in) investing activities 737,828 (6,521)
Cash flows from financing activities:    
Repayment of short-term borrowings   (2,130)
Proceeds from exercises of stock options 3,992 3,075
Proceeds from issuance of ordinary shares upon public offerings 818,874 281,295
Payment of public offering costs (1,323) (740)
Employee taxes paid related to net share settlement of equity awards (594)  
Net cash provided by financing activities 820,949 281,500
Effect of foreign exchange rate changes on cash, cash equivalents and restricted cash 1,028 12
Net increase in cash, cash equivalents and restricted cash 1,324,457 182,672
Cash, cash equivalents and restricted cash - beginning of period 442,859 76,442
Cash, cash equivalents and restricted cash - end of period 1,767,316 259,114
Supplemental disclosure on non-cash investing and financing activities:    
Payables for purchase of property and equipment 1,720 984
Payables for intangible assets 58  
Payables for public offering costs 555  
Supplemental disclosure of cash flow information:    
Cash and cash equivalents 1,766,573 258,604
Restricted cash, non-current 743 510
Total cash and cash equivalents and restricted cash $ 1,767,316 259,114
Interest paid   $ 122