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Consolidated statements of shareholders' equity - USD ($)
$ in Thousands
Total
Ordinary Shares
Additional Paid In Capital
Accumulated Deficit
Accumulated Other Comprehensive (Loss) Income
Treasury Stock
Balance at Dec. 31, 2019 $ 294,660 $ 4 $ 734,734 $ (444,698) $ 4,620  
Balance, Shares at Dec. 31, 2019   68,237,247        
Issuance of ordinary shares upon vesting of restricted shares   $ 0 0      
Issuance of ordinary shares upon vesting of restricted shares, Shares   80,200        
Exercise of shares option 346 $ 0 346      
Exercise of shares option, Shares   49,278        
Issuance of ordinary shares upon follow-on public offering, net of issuance cost 280,568 $ 0 280,568      
Issuance of ordinary shares upon follow-on public offering, net of issuance cost, Shares   6,300,000        
Issuance cost adjustment for secondary listing          
Share-based compensation 6,463   6,463      
Net loss (47,988)     (47,988)    
Foreign currency translation 3,539       3,539  
Balance at Mar. 31, 2020 537,588 $ 4 1,022,111 (492,686) 8,159  
Balance, Shares at Mar. 31, 2020   74,666,725        
Balance at Dec. 31, 2019 294,660 $ 4 734,734 (444,698) 4,620  
Balance, Shares at Dec. 31, 2019   68,237,247        
Net loss (192,358)          
Foreign currency translation (7,535)          
Balance at Sep. 30, 2020 1,139,041 $ 5 1,779,007 (637,056) (2,915)  
Balance, Shares at Sep. 30, 2020   86,097,518        
Balance at Mar. 31, 2020 537,588 $ 4 1,022,111 (492,686) 8,159  
Balance, Shares at Mar. 31, 2020   74,666,725        
Issuance of ordinary shares upon vesting of restricted shares 0 $ 0 0      
Issuance of ordinary shares upon vesting of restricted shares, Shares   36,000        
Exercise of shares option 2,729 $ 0 2,729      
Exercise of shares option, Shares   179,613        
Issuance cost adjustment for follow-on public offering (13)   (13)      
Share-based compensation 6,964   6,964      
Net loss (80,629)     (80,629)    
Foreign currency translation (1,173)       (1,173)  
Balance at Jun. 30, 2020 465,466 $ 4 1,031,791 (573,315) 6,986  
Balance, Shares at Jun. 30, 2020   74,882,338        
Issuance of ordinary shares upon vesting of restricted shares 0 $ 0 0      
Issuance of ordinary shares upon vesting of restricted shares, Shares   90,468        
Exercise of shares option 1,008 $ 0 1,008      
Exercise of shares option, Shares   560,662        
Issuance cost adjustment for secondary listing 5,634          
Issuance cost adjustment for follow-on public offering (2)   (2)      
Issuance of ordinary shares upon secondary listing, net of issuance cost 739,233 $ 1 739,232      
Issuance of ordinary shares upon secondary listing, net of issuance cost, Shares   10,564,050        
Share-based compensation 6,978   6,978      
Net loss (63,741)     (63,741)    
Foreign currency translation (9,901)       (9,901)  
Balance at Sep. 30, 2020 1,139,041 $ 5 1,779,007 (637,056) (2,915)  
Balance, Shares at Sep. 30, 2020   86,097,518        
Balance at Dec. 31, 2020 $ 1,169,345 $ 5 1,897,467 (713,603) (14,524)  
Balance, Shares at Dec. 31, 2020 87,811,026 87,811,026        
Issuance of ordinary shares upon vesting of restricted shares   $ 0 0      
Issuance of ordinary shares upon vesting of restricted shares, Shares   81,600        
Exercise of shares option $ 702 $ 0 702      
Exercise of shares option, Shares   58,364        
Issuance of ordinary shares in connection with collaboration and license arrangement 62,250 $ 0 62,250      
Issuance of ordinary shares in connection with collaboration and license arrangement, Shares   568,182        
Issuance cost adjustment for secondary listing 65   65      
Share-based compensation 7,318   7,318      
Net loss (232,910)     (232,910)    
Foreign currency translation 2,900       2,900  
Balance at Mar. 31, 2021 1,009,670 $ 5 1,967,802 (946,513) (11,624)  
Balance, Shares at Mar. 31, 2021   88,519,172        
Balance at Dec. 31, 2020 $ 1,169,345 $ 5 1,897,467 (713,603) (14,524)  
Balance, Shares at Dec. 31, 2020 87,811,026 87,811,026        
Net loss $ (492,646)          
Foreign currency translation (600)          
Balance at Sep. 30, 2021 $ 1,587,930 $ 6 2,812,830 (1,206,249) (15,124) $ (3,533)
Balance, Shares at Sep. 30, 2021 95,273,589 95,273,589       (27,722)
Balance at Mar. 31, 2021 $ 1,009,670 $ 5 1,967,802 (946,513) (11,624)  
Balance, Shares at Mar. 31, 2021   88,519,172        
Issuance of ordinary shares upon vesting of restricted shares 0 $ 0 0      
Issuance of ordinary shares upon vesting of restricted shares, Shares   32,100        
Exercise of shares option 3,289 $ 0 3,289      
Exercise of shares option, Shares   490,517        
Receipt of employees' shares to satisfy tax withholding obligations related to share-based compensation           (6,086)
Receipt of employees' shares to satisfy tax withholding obligations related to share-based compensation (924)         $ (924)
Issuance of ordinary shares upon follow-on public offering, net of issuance cost 817,996 $ 1 817,995      
Issuance of ordinary shares upon follow-on public offering, net of issuance cost, Shares   5,716,400        
Issuance cost adjustment for secondary listing          
Share-based compensation 10,232   10,232      
Net loss (163,324)     (163,324)    
Foreign currency translation (5,241)       (5,241)  
Balance at Jun. 30, 2021 1,671,698 $ 6 2,799,318 (1,109,837) (16,865) $ (924)
Balance, Shares at Jun. 30, 2021   94,758,189       (6,086)
Issuance of ordinary shares upon vesting of restricted shares 0 $ 0 0      
Issuance of ordinary shares upon vesting of restricted shares, Shares   54,050        
Exercise of shares option 2,916 $ 0 2,916      
Exercise of shares option, Shares   461,350        
Receipt of employees' shares to satisfy tax withholding obligations related to share-based compensation           (21,636)
Receipt of employees' shares to satisfy tax withholding obligations related to share-based compensation (2,609)         $ (2,609)
Issuance cost adjustment for follow-on public offering 40   40      
Share-based compensation 10,556   10,556      
Net loss (96,412)     (96,412)    
Foreign currency translation 1,741       1,741  
Balance at Sep. 30, 2021 $ 1,587,930 $ 6 $ 2,812,830 $ (1,206,249) $ (15,124) $ (3,533)
Balance, Shares at Sep. 30, 2021 95,273,589 95,273,589       (27,722)