<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2024 Workiva-->
<!--r:3eae8d64-35aa-427e-bba6-fd2c5d91f97b,g:cbec7551-7d54-439c-a640-6a5a51286ddc-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://zailab.com/role/Cover" xlink:type="simple" xlink:href="zlab-20240205.xsd#Cover"/>
  <link:presentationLink xlink:role="http://zailab.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_388fc285-7cd6-4074-9530-ba6e84862840" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationTable_85f59fc2-f300-4ebc-b33e-29063f2a3923" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentInformationTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_388fc285-7cd6-4074-9530-ba6e84862840" xlink:to="loc_dei_DocumentInformationTable_85f59fc2-f300-4ebc-b33e-29063f2a3923" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_d5fac3ae-3f94-48cc-a9da-8c693359890e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationTable_85f59fc2-f300-4ebc-b33e-29063f2a3923" xlink:to="loc_us-gaap_StatementClassOfStockAxis_d5fac3ae-3f94-48cc-a9da-8c693359890e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_4fa22e0e-da5c-44fb-9eba-ee8d459b9a30" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_d5fac3ae-3f94-48cc-a9da-8c693359890e" xlink:to="loc_us-gaap_ClassOfStockDomain_4fa22e0e-da5c-44fb-9eba-ee8d459b9a30" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AdrMember_837dc1be-dd99-47b2-b015-4007b0f232fe" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_AdrMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_4fa22e0e-da5c-44fb-9eba-ee8d459b9a30" xlink:to="loc_dei_AdrMember_837dc1be-dd99-47b2-b015-4007b0f232fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_d840b281-a6c4-4d4a-b5db-19679db565e3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_4fa22e0e-da5c-44fb-9eba-ee8d459b9a30" xlink:to="loc_us-gaap_CommonStockMember_d840b281-a6c4-4d4a-b5db-19679db565e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentInformationLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationTable_85f59fc2-f300-4ebc-b33e-29063f2a3923" xlink:to="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_204340df-0a64-4ab1-8f7e-8c710680c074" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_DocumentType_204340df-0a64-4ab1-8f7e-8c710680c074" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_9072f309-5a89-4b48-9afb-de9b505461a5" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_DocumentPeriodEndDate_9072f309-5a89-4b48-9afb-de9b505461a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_76744357-3a20-4e5f-9956-940d99d30604" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_EntityRegistrantName_76744357-3a20-4e5f-9956-940d99d30604" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_b8c18904-02d5-40ce-919f-a53e6f24f9a1" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_EntityIncorporationStateCountryCode_b8c18904-02d5-40ce-919f-a53e6f24f9a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_c335461e-a24e-4202-bacd-e6e84b161752" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_EntityFileNumber_c335461e-a24e-4202-bacd-e6e84b161752" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_3786597a-0580-4901-9c57-c3e2d27211b8" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_EntityTaxIdentificationNumber_3786597a-0580-4901-9c57-c3e2d27211b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_f739ae85-7733-4f3d-8305-deceb4ce4c91" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_EntityAddressAddressLine1_f739ae85-7733-4f3d-8305-deceb4ce4c91" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_26d7bc18-d717-477d-b280-07aebc95e0b6" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_EntityAddressAddressLine2_26d7bc18-d717-477d-b280-07aebc95e0b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_c0c18459-4ada-490d-87f9-fdc230389a9d" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_EntityAddressCityOrTown_c0c18459-4ada-490d-87f9-fdc230389a9d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCountry_8f6322cb-1cdf-4b00-a0de-181131a98cb8" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressCountry"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_EntityAddressCountry_8f6322cb-1cdf-4b00-a0de-181131a98cb8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_9871cb8c-44b2-43cc-98c3-eaa9b9b1a4a5" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_EntityAddressPostalZipCode_9871cb8c-44b2-43cc-98c3-eaa9b9b1a4a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_1d98078f-97d9-4c24-b16b-df1af7a1f349" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_CityAreaCode_1d98078f-97d9-4c24-b16b-df1af7a1f349" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_014f8664-fca4-41f7-9b0e-adac04862c53" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_LocalPhoneNumber_014f8664-fca4-41f7-9b0e-adac04862c53" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_4be4dd92-ec7a-403d-be27-bb71d5bb8643" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_WrittenCommunications_4be4dd92-ec7a-403d-be27-bb71d5bb8643" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_1ec61d46-c3d3-494a-a5bf-792af4b65d5c" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_SolicitingMaterial_1ec61d46-c3d3-494a-a5bf-792af4b65d5c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_447bbe5c-b613-4704-ab02-7429aed4dfbc" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_PreCommencementTenderOffer_447bbe5c-b613-4704-ab02-7429aed4dfbc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_36fa23b0-a308-4453-83cc-c8d41c3e95e3" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_36fa23b0-a308-4453-83cc-c8d41c3e95e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_bc7c22ef-bdfb-42ed-942e-ecd03cf73f67" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_Security12bTitle_bc7c22ef-bdfb-42ed-942e-ecd03cf73f67" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_09fdc762-d014-4ad2-8355-05afd698450a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_TradingSymbol_09fdc762-d014-4ad2-8355-05afd698450a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_fce15a01-51c0-4e59-9217-0905e810d436" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_SecurityExchangeName_fce15a01-51c0-4e59-9217-0905e810d436" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_0a92318a-7de7-4e4d-9e6b-2cc573600773" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_EntityEmergingGrowthCompany_0a92318a-7de7-4e4d-9e6b-2cc573600773" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_4ac6b095-9a3f-4739-857a-1bd286884980" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_AmendmentFlag_4ac6b095-9a3f-4739-857a-1bd286884980" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_815075b5-3350-42a7-8544-f0e43d4a5512" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_6ddef750-7da9-4415-a9d7-df70f6fc4cc5" xlink:to="loc_dei_EntityCentralIndexKey_815075b5-3350-42a7-8544-f0e43d4a5512" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
