<SEC-DOCUMENT>0001493215-25-000053.txt : 20251114
<SEC-HEADER>0001493215-25-000053.hdr.sgml : 20251114
<ACCEPTANCE-DATETIME>20251114083557
ACCESSION NUMBER:		0001493215-25-000053
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20251114
DATE AS OF CHANGE:		20251114

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Zai Lab Ltd
		CENTRAL INDEX KEY:			0001704292
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			E9
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-90351
		FILM NUMBER:		251481485

	BUSINESS ADDRESS:	
		ADDRESS IS A NON US LOCATION: 	YES
		STREET 1:		899 HALEI ROAD
		STREET 2:		BUILDING B, PUDONG
		CITY:			SHANGHAI
		PROVINCE COUNTRY:   	F4
		BUSINESS PHONE:		862161632588

	MAIL ADDRESS:	
		ADDRESS IS A NON US LOCATION: 	YES
		STREET 1:		899 HALEI ROAD
		STREET 2:		BUILDING B, PUDONG
		CITY:			SHANGHAI
		PROVINCE COUNTRY:   	F4

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			RTW INVESTMENTS, LP
		CENTRAL INDEX KEY:			0001493215
		ORGANIZATION NAME:           	
		EIN:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		40 10TH AVENUE
		STREET 2:		7TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10014
		BUSINESS PHONE:		646-597-6980

	MAIL ADDRESS:	
		STREET 1:		40 10TH AVENUE
		STREET 2:		7TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10014

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	RTW INVESTMENTS, LLC
		DATE OF NAME CHANGE:	20100602
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13G/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
		<previousAccessionNumber>0001415889-25-021718</previousAccessionNumber>
	    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001493215</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>





    </filerInfo>
  </headerData>

  <formData>
    <coverPageHeader>
		<amendmentNo>1</amendmentNo>
	      <securitiesClassTitle>Ordinary Shares, par value $0.000006 per share</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>09/30/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001704292</issuerCik>        <issuerName>Zai Lab Limited</issuerName>        <issuerCusip>98887Q104</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>314 Main Street</com:street1>
          <com:street2>4th Floor, Suite 100</com:street2>          <com:city>Cambridge</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02142</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>

	        <designateRulesPursuantThisScheduleFiled>
	   		        <designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
				      </designateRulesPursuantThisScheduleFiled>

    </coverPageHeader>

	    <coverPageHeaderReportingPersonDetails>




    <reportingPersonName>RTW Investments, LP</reportingPersonName>



		 <citizenshipOrOrganization>DE</citizenshipOrOrganization>

      <reportingPersonBeneficiallyOwnedNumberOfShares>
                <soleVotingPower>0.00</soleVotingPower>
                          <sharedVotingPower>22913720.00</sharedVotingPower>
                          <soleDispositivePower>0.00</soleDispositivePower>
                         <sharedDispositivePower>22913720.00</sharedDispositivePower>
             </reportingPersonBeneficiallyOwnedNumberOfShares>

              <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>22913720.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>


     	    <classPercent>2.1</classPercent>




	  	  	  	  <typeOfReportingPerson>IA</typeOfReportingPerson>

	        <typeOfReportingPerson>PN</typeOfReportingPerson>









    </coverPageHeaderReportingPersonDetails>
	    <coverPageHeaderReportingPersonDetails>




    <reportingPersonName>Roderick Wong</reportingPersonName>



		 <citizenshipOrOrganization>X1</citizenshipOrOrganization>

      <reportingPersonBeneficiallyOwnedNumberOfShares>
                <soleVotingPower>0.00</soleVotingPower>
                          <sharedVotingPower>22913720.00</sharedVotingPower>
                          <soleDispositivePower>0.00</soleDispositivePower>
                         <sharedDispositivePower>22913720.00</sharedDispositivePower>
             </reportingPersonBeneficiallyOwnedNumberOfShares>

              <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>22913720.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>


     	    <classPercent>2.1</classPercent>







	        <typeOfReportingPerson>HC</typeOfReportingPerson>



	        <typeOfReportingPerson>IN</typeOfReportingPerson>




    </coverPageHeaderReportingPersonDetails>

    <items>
      <item1>
        <issuerName>Zai Lab Limited</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>314 Main Street, 4th Floor, Suite 100, Cambridge, MA, 02142.</issuerPrincipalExecutiveOfficeAddress>
      </item1>

      <item2>
        <filingPersonName>This statement is filed by:

(i) RTW Investments, LP ("RTW Investments"), a Delaware limited partnership and the investment adviser to certain funds (the "RTW Funds"), with respect to the Ordinary Shares, par value $0.000006 per share (the "Shares") of Zai Lab Limited (the "Issuer") directly held by the RTW Funds; and

(ii) Roderick Wong, M.D. ("Dr. Wong"), the Managing Partner and Chief Investment Officer of RTW Investments, with respect to the Shares directly held by the RTW Funds.

The foregoing persons are hereinafter sometimes collectively referred to as the "Reporting Persons."

The filing of this statement should not be construed as an admission that any of the foregoing persons or any Reporting Person is, for the purposes of Section 13 of the Securities Exchange Act of 1934, as amended, the beneficial owner of the Shares reported herein.</filingPersonName>        <principalBusinessOfficeOrResidenceAddress>The address of the business office of each of the Reporting Persons is 40 10th Avenue, Floor 7, New York, New York 10014.</principalBusinessOfficeOrResidenceAddress>        <citizenship>RTW Investments is a Delaware limited partnership. Dr. Wong is a citizen of the United States.</citizenship>      </item2>

        <item3>
				<notApplicableFlag>N</notApplicableFlag>





		<typeOfPersonFiling>IA</typeOfPersonFiling>

		<typeOfPersonFiling>HC</typeOfPersonFiling>







      </item3>



    <item4>
    <amountBeneficiallyOwned>There is no CUSIP number assigned to the Shares. CUSIP number 98887Q104 has been assigned to the American Depositary Shares ("ADSs") of the Issuer. Each ADS represents ten Shares.

The information required by Item 4(a) is set forth in Rows 5 - 9 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The percentage set forth in Row 11 of each cover page is calculated based upon 1,099,557,340 Shares outstanding as of July 31, 2025, as reported in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (the "SEC") on August 7, 2025.  </amountBeneficiallyOwned>    <classPercent>RTW Investments: 2.1%
Dr. Wong: 2.1%</classPercent>
      <numberOfSharesPersonHas>
        <solePowerOrDirectToVote>RTW Investments: 0
Dr. Wong: 0</solePowerOrDirectToVote>
        <sharedPowerOrDirectToVote>RTW Investments: 22,913,720 Shares
Dr. Wong: 22,913,720 Shares</sharedPowerOrDirectToVote>
        <solePowerOrDirectToDispose>RTW Investments: 0
Dr. Wong: 0</solePowerOrDirectToDispose>
        <sharedPowerOrDirectToDispose>RTW Investments: 22,913,720 Shares
Dr. Wong: 22,913,720 Shares</sharedPowerOrDirectToDispose>
      </numberOfSharesPersonHas>
    </item4>


        <item5>

            <notApplicableFlag>N</notApplicableFlag>
        <classOwnership5PercentOrLess>Y</classOwnership5PercentOrLess>

    </item5>


        <item6>
	              <notApplicableFlag>N</notApplicableFlag>
        <ownershipMoreThan5PercentOnBehalfOfAnotherPerson>See Item 2.  The RTW Funds have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the Shares reported herein.</ownershipMoreThan5PercentOnBehalfOfAnotherPerson>
		     </item6>


        <item7>
	  	  <notApplicableFlag>Y</notApplicableFlag>


    </item7>


          <item8>
                <notApplicableFlag>Y</notApplicableFlag>

              </item8>


            <item9>
                <notApplicableFlag>Y</notApplicableFlag>
                      </item9>


      <item10>
                <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>

      </item10>
    </items>

		<exhibitInfo>Exhibit 99.1	Joint Filing Agreement (incorporated by reference to Exhibit 99.1 to the Reporting Persons' Schedule 13G filed with the SEC on August 14, 2025).</exhibitInfo>

	    <signatureInformation>
      <reportingPersonName>RTW Investments, LP</reportingPersonName>

      <signatureDetails>
        <signature>/s/ Roderick Wong, M.D.</signature>
        <title>By Roderick Wong, M.D., Managing Partner </title>
        <date>11/14/2025</date>
      </signatureDetails>

    </signatureInformation>
	     <signatureInformation>
      <reportingPersonName>Roderick Wong</reportingPersonName>

      <signatureDetails>
        <signature>/s/ Roderick Wong, M.D.</signature>
        <title>Roderick Wong, M.D.</title>
        <date>11/14/2025</date>
      </signatureDetails>

    </signatureInformation>



  </formData>

    </edgarSubmission>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
