<SEC-DOCUMENT>0001959173-25-007948.txt : 20251231
<SEC-HEADER>0001959173-25-007948.hdr.sgml : 20251231
<ACCEPTANCE-DATETIME>20251231152902
ACCESSION NUMBER:		0001959173-25-007948
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20251231
DATE AS OF CHANGE:		20251231

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Zai Lab Ltd
		CENTRAL INDEX KEY:			0001704292
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			E9
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-38205
		FILM NUMBER:		251617274

	BUSINESS ADDRESS:	
		ADDRESS IS A NON US LOCATION: 	YES
		STREET 1:		899 HALEI ROAD
		STREET 2:		BUILDING B, PUDONG
		CITY:			SHANGHAI
		PROVINCE COUNTRY:   	F4
		BUSINESS PHONE:		862161632588

	MAIL ADDRESS:	
		ADDRESS IS A NON US LOCATION: 	YES
		STREET 1:		899 HALEI ROAD
		STREET 2:		BUILDING B, PUDONG
		CITY:			SHANGHAI
		PROVINCE COUNTRY:   	F4

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Amado Rafael
		CENTRAL INDEX KEY:			0001662119
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		314 MAIN STREET
		STREET 2:		4TH FLOOR, SUITE 100
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001662119</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



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  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001704292</issuerCik>
      <issuerName>Zai Lab Ltd</issuerName>
      <secFileNumber>001-38205</secFileNumber>
      <issuerAddress>
        <com:street1>899 HALEI ROAD</com:street1>
        <com:street2>BUILDING B, PUDONG</com:street2>
        <com:city>SHANGHAI</com:city>
        <com:stateOrCountry>F4</com:stateOrCountry>
        <com:zipCode>201203</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>862161632588</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Amado Rafael</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>10787</noOfUnitsSold>
      <aggregateMarketValue>188033.59</aggregateMarketValue>
      <noOfUnitsOutstanding>355325670</noOfUnitsOutstanding>
      <approxSaleDate>12/31/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>American Depositary Shares</securitiesClassTitle>
      <acquiredDate>12/30/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Vesting</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>10787</amountOfSecuritiesAcquired>
      <paymentDate>12/30/2025</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>Sale includes an amount necessary to cover a tax obligation resulting from the settlement of a vested equity award distribution.</remarks>
    <noticeSignature>
      <noticeDate>12/31/2025</noticeDate>
      <signature>/s/ Gerardo Ibarra-Munoz, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Rafael Amado</signature>
    </noticeSignature>
  </formData>
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