    <SEC-DOCUMENT>0001818331-24-000027-index.html : 20240429
    <SEC-HEADER>0001818331-24-000027.hdr.sgml : 20240429
    <ACCEPTANCE-DATETIME>20240429162507
    ACCESSION NUMBER:		0001818331-24-000027
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20231231
    FILED AS OF DATE:		20240429
    DATE AS OF CHANGE:		20240429
    EFFECTIVENESS DATE:		20240429

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			GeneDx Holdings Corp.
    		CENTRAL INDEX KEY:			0001818331
    		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-HEALTH SERVICES [8000]
    		ORGANIZATION NAME:           	08 Industrial Applications and Services
    		IRS NUMBER:				851966622
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-39482
    		FILM NUMBER:		24891306

    	BUSINESS ADDRESS:
    		STREET 1:		333 LUDLOW STREET
    		STREET 2:		NORTH TOWER, 8TH FLOOR
    		CITY:			STAMFORD
    		STATE:			CT
    		ZIP:			06902
    		BUSINESS PHONE:		617 780 8742

    	MAIL ADDRESS:
    		STREET 1:		333 LUDLOW STREET
    		STREET 2:		NORTH TOWER, 8TH FLOOR
    		CITY:			STAMFORD
    		STATE:			CT
    		ZIP:			06902

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Sema4 Holdings Corp.
    		DATE OF NAME CHANGE:	20210721

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	CM Life Sciences, Inc.
    		DATE OF NAME CHANGE:	20200715
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>arsgenedx-2023x1231x10xk.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: arsgenedx-2023x1231x10xk.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>