<SEC-DOCUMENT>0002083937-25-000011.txt : 20250919
<SEC-HEADER>0002083937-25-000011.hdr.sgml : 20250919
<ACCEPTANCE-DATETIME>20250919161021
ACCESSION NUMBER:		0002083937-25-000011
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20250917
FILED AS OF DATE:		20250919
DATE AS OF CHANGE:		20250919

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Fuchs Thomas
		CENTRAL INDEX KEY:			0002083937
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39482
		FILM NUMBER:		251326938

	MAIL ADDRESS:	
		STREET 1:		333 LUDLOW STREET
		STREET 2:		NORTH TOWER, 6TH FLOOR
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			30346

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GeneDx Holdings Corp.
		CENTRAL INDEX KEY:			0001818331
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-HEALTH SERVICES [8000]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				851966622
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		333 LUDLOW STREET
		STREET 2:		NORTH TOWER, 6TH FLOOR
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			06902
		BUSINESS PHONE:		888-729-1206

	MAIL ADDRESS:	
		STREET 1:		333 LUDLOW STREET
		STREET 2:		NORTH TOWER, 6TH FLOOR
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			06902

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Sema4 Holdings Corp.
		DATE OF NAME CHANGE:	20210721

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CM Life Sciences, Inc.
		DATE OF NAME CHANGE:	20200715
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>form3-09192025_080917.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2025-09-17</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001818331</issuerCik>
        <issuerName>GeneDx Holdings Corp.</issuerName>
        <issuerTradingSymbol>WGS</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0002083937</rptOwnerCik>
            <rptOwnerName>Fuchs Thomas</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O GENEDX HOLDINGS CORP.</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>STAMFORD</rptOwnerCity>
            <rptOwnerState>CT</rptOwnerState>
            <rptOwnerZipCode>06902</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes></footnotes>

    <ownerSignature>
        <signatureName>/s/ Bridget Brown, Attorney-in-Fact</signatureName>
        <signatureDate>2025-09-19</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>ex24-09192025_080925.htm
<TEXT>
<!DOCTYPE html PUBLIC "-//IETF//DTD HTML//EN">
<html><head><title>ex24-09192025_080925.htm</title></head><body style="margin-top:0;font-family:Times New Roman; font-size:10pt; color:#000000">
<p style="margin:0px; padding-right:13.467px; font-size:11pt" align="center"><b>LIMITED POWER OF ATTORNEY</b></p>
<p style="margin:0px" align="center"><br></p>
<p style="margin:0px; padding-left:6.267px; padding-right:26.267px; text-indent:46.8px; font-size:11pt" align="justify">The undersigned hereby constitutes and appoints Daniel Fine, Samantha McWatters and Bridget Brown, as long as they are providing services to GeneDx Holdings Corp., a Delaware corporation (the <font style="font-family:Arial Unicode MS,Times New Roman">&ldquo;</font><b>Company</b><font style="font-family:Arial Unicode MS,Times New Roman">&rdquo;</font>), or either of them, acting individually, as the undersigned<font style="font-family:Arial Unicode MS,Times New Roman">&rsquo;</font>s true and lawful attorney-in-fact to:</p>
<p style="margin:0px" align="justify"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; text-indent:60.4px; width:107.067px; font-family:Arial; float:left">(1)</p>
<p style="margin:0px; padding-left:107.067px; padding-right:26.8px; text-indent:-2px; font-size:11pt" align="justify">execute for and on behalf of the undersigned, in the undersigned<font style="font-family:Arial Unicode MS,Times New Roman">&rsquo;</font>s capacity as an officer and/or director of the Company, Forms 3, 4, and 5, and any amendments thereto, in accordance with Section 16(a) of the Securities Exchange Act of 1934 (as amended, the <font style="font-family:Arial Unicode MS,Times New Roman">&ldquo;</font><b>Exchange Act</b><font style="font-family:Arial Unicode MS,Times New Roman">&rdquo;</font>), and the rules and regulations thereunder;</p>
<p style="margin:0px; clear:left" align="justify"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; text-indent:60.4px; width:107.067px; font-family:Arial; font-size:11pt; float:left">(2)</p>
<p style="margin:0px; padding-left:107.067px; padding-right:26.733px; text-indent:-2px; font-size:11pt" align="justify">do and perform any and all acts for and on<i> </i>behalf of the undersigned that may be necessary or desirable to complete and execute any such Forms 3, 4, and 5,<i> </i>and any amendments thereto, and file such forms with the United States Securities and Exchange Commission and any stock exchange or similar authority, if required; and</p>
<p style="margin:0px; clear:left" align="justify"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; text-indent:60.4px; width:107.067px; font-family:Arial; font-size:11pt; float:left">(3)</p>
<p style="margin:0px; padding-left:107.067px; padding-right:26.733px; text-indent:-2px; font-size:11pt" align="justify">take any other action of any type whatsoever in connection with the foregoing that, in the opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such terms and conditions as such attorney-in-fact may approve in such attorney-in-fact<font style="font-family:Arial Unicode MS,Times New Roman">&rsquo;</font>s discretion.</p>
<p style="margin:0px; clear:left"><br></p>
<p style="margin:0px; padding-left:13.4px; padding-right:24.933px; text-indent:47.4px; font-size:11pt" align="justify">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform each and every act and thing whatsoever requisite, necessary or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power of substitution and revocation, hereby ratifying and confirming all that each such attorney-in-fact, or each such attorney-in-fact<font style="font-family:Arial Unicode MS,Times New Roman">&rsquo;</font>s substitute or substitutes, shall lawfully do or cause to be done by virtue of this Power of Attorney and the rights and powers herein granted. The undersigned acknowledges that each of the foregoing attorneys-in-fact, in serving in such capacity at the request of the undersigned, is not assuming, nor is the Company assuming, any of the undersigned<font style="font-family:Arial Unicode MS,Times New Roman">&rsquo;</font>s responsibilities to comply with Section 16 of the Exchange Act.</p>
<p style="margin:0px" align="justify"><br></p>
<p style="margin:0px; padding-left:13.8px; padding-right:25.733px; text-indent:44.933px; font-size:11pt" align="justify">The undersigned agrees that each such attorney-in-fact may rely entirely on information furnished orally or in writing by the undersigned to each such attorney-in-fact. The undersigned also agrees to indemnify and hold harmless the Company and each such attorney-in-fact against any losses, claims, damages or liabilities (or actions in these respects) that arise out of or are based on any untrue statement or omission of necessary facts in the information provided by<b> </b>the undersigned to such attorney-in-fact for purposes of executing, acknowledging, delivering and filing Forms 3, 4 or 5 (including amendments thereto) and agrees to reimburse the Company and each such attorney-in-fact for any legal or other expenses reasonably incurred in connection with investigating or defending against any such loss, claim, damage, liability or action.</p>
<p style="margin:0px" align="justify"><br></p>
<p style="margin:0px; padding-left:13.8px; padding-right:25.733px; text-indent:44.933px; font-size:11pt" align="justify">This Power of Attorney supersedes and replaces all prior Powers of Attorney submitted by the undersigned. &nbsp;This Power of Attorney shall remain in full force and effect until the undersigned is no longer required to file Forms 3, 4, and 5 with respect to the undersigned<font style="font-family:Arial Unicode MS,Times New Roman">&rsquo;</font>s holdings of, and transactions in securities issued by, the Company, unless earlier revoked by the undersigned in a signed writing delivered to the foregoing attorneys-in-fact.</p>
<p style="margin:0px" align="justify"><br></p>
<p style="margin:0px; padding-left:13.8px; padding-right:25.733px; text-indent:44.933px; font-size:11pt" align="justify"><b>IN WITNESS WHEREOF</b>, the undersigned has caused this Power of Attorney to be executed as of this 19<sup>th</sup> day of August 2025.</p>
<p style="margin:0px" align="justify"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; text-indent:288px; width:336px; font-size:11pt; float:left">By:</p>
<p style="margin:0px; padding-left:288px; padding-right:25.933px; text-indent:-2px; font-size:11pt" align="justify"><u>/s/ Thomas Fuchs</u></p>
<p style="margin-top:0px; margin-bottom:-2px; text-indent:288px; width:336px; font-size:11pt; clear:left; float:left">Name:</p>
<p style="margin:0px; padding-left:288px; padding-right:25.933px; text-indent:-2px; font-size:11pt" align="justify">Thomas Fuchs</p>
<p style="margin:0px; clear:left" align="justify"><br></p>
</body></html>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
