<SEC-DOCUMENT>0001971857-25-000021.txt : 20250102
<SEC-HEADER>0001971857-25-000021.hdr.sgml : 20250102
<ACCEPTANCE-DATETIME>20250102170302
ACCESSION NUMBER:		0001971857-25-000021
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250102
DATE AS OF CHANGE:		20250102

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GeneDx Holdings Corp.
		CENTRAL INDEX KEY:			0001818331
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-HEALTH SERVICES [8000]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		IRS NUMBER:				851966622
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-39482
		FILM NUMBER:		25502807

	BUSINESS ADDRESS:	
		STREET 1:		333 LUDLOW STREET
		STREET 2:		NORTH TOWER, 8TH FLOOR
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			06902
		BUSINESS PHONE:		617 780 8742

	MAIL ADDRESS:	
		STREET 1:		333 LUDLOW STREET
		STREET 2:		NORTH TOWER, 8TH FLOOR
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			06902

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Sema4 Holdings Corp.
		DATE OF NAME CHANGE:	20210721

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CM Life Sciences, Inc.
		DATE OF NAME CHANGE:	20200715

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Feeley Kevin
		CENTRAL INDEX KEY:			0001944119
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		C/O SEMA4 HOLDINGS CORP
		STREET 2:		333 LUDLOW STREET, NORTH TOWER, 8TH FL.
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			06902
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001944119</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001818331</issuerCik>
      <issuerName>GeneDx Holdings Corp.</issuerName>
      <secFileNumber>001-39482</secFileNumber>
      <issuerAddress>
        <com:street1>333 LUDLOW STREET</com:street1>
        <com:street2>NORTH TOWER, 8TH FLOOR</com:street2>
        <com:city>STAMFORD</com:city>
        <com:stateOrCountry>CT</com:stateOrCountry>
        <com:zipCode>06902</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>617 780 8742</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Feeley Kevin</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill Lynch</name>
        <address>
          <com:street1>2049 Century Park E</com:street1>
          <com:street2>Ste 1200</com:street2>
          <com:city>Los Angeles</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>90067</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>1430</noOfUnitsSold>
      <aggregateMarketValue>108000.00</aggregateMarketValue>
      <noOfUnitsOutstanding>27471397</noOfUnitsOutstanding>
      <approxSaleDate>01/02/2025</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>10/29/2024</acquiredDate>
      <natureOfAcquisitionTransaction>RSU vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>119</amountOfSecuritiesAcquired>
      <paymentDate>10/29/2024</paymentDate>
      <natureOfPayment>cashless</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/02/2024</acquiredDate>
      <natureOfAcquisitionTransaction>RSU vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>113</amountOfSecuritiesAcquired>
      <paymentDate>12/02/2024</paymentDate>
      <natureOfPayment>cashless</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/09/2024</acquiredDate>
      <natureOfAcquisitionTransaction>RSU vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>331</amountOfSecuritiesAcquired>
      <paymentDate>12/09/2024</paymentDate>
      <natureOfPayment>cashless</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/16/2024</acquiredDate>
      <natureOfAcquisitionTransaction>RSU vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>867</amountOfSecuritiesAcquired>
      <paymentDate>12/16/2024</paymentDate>
      <natureOfPayment>cashless</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St</com:street1>
          <com:street2>North Tower, 6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>10/29/2024</saleDate>
      <amountOfSecuritiesSold>274</amountOfSecuritiesSold>
      <grossProceeds>18000.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St</com:street1>
          <com:street2>North Tower, 6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>11/21/2024</saleDate>
      <amountOfSecuritiesSold>12019</amountOfSecuritiesSold>
      <grossProceeds>886000.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St</com:street1>
          <com:street2>North Tower, 6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>11/22/2024</saleDate>
      <amountOfSecuritiesSold>9981</amountOfSecuritiesSold>
      <grossProceeds>758000.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St</com:street1>
          <com:street2>North Tower, 6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>12/02/2024</saleDate>
      <amountOfSecuritiesSold>263</amountOfSecuritiesSold>
      <grossProceeds>20000.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St</com:street1>
          <com:street2>North Tower, 6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>12/09/2024</saleDate>
      <amountOfSecuritiesSold>1137</amountOfSecuritiesSold>
      <grossProceeds>87000.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kevin Feeley</name>
        <address>
          <com:street1>333 Ludlow St</com:street1>
          <com:street2>North Tower, 6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>12/16/2024</saleDate>
      <amountOfSecuritiesSold>3728</amountOfSecuritiesSold>
      <grossProceeds>286000.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>The sales from 10/29/24, 12/2/24, 12/9/24, and 12/16/24 reported on this form 144 represent shares sold in the past 3 months by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of RSUs. The sales were to satisfy tax withholding obligations to be funded by a sell to cover transaction.
</remarks>
    <noticeSignature>
      <noticeDate>01/02/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>08/21/2024</planAdoptionDate>
      </planAdoptionDates>
      <signature>Kevin Feeley</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
