<SEC-DOCUMENT>0001818331-25-000034.txt : 20250310
<SEC-HEADER>0001818331-25-000034.hdr.sgml : 20250310
<ACCEPTANCE-DATETIME>20250310194324
ACCESSION NUMBER:		0001818331-25-000034
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250310
DATE AS OF CHANGE:		20250310

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GeneDx Holdings Corp.
		CENTRAL INDEX KEY:			0001818331
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-HEALTH SERVICES [8000]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		IRS NUMBER:				851966622
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-39482
		FILM NUMBER:		25725418

	BUSINESS ADDRESS:	
		STREET 1:		333 LUDLOW STREET
		STREET 2:		NORTH TOWER, 6TH FLOOR
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			06902
		BUSINESS PHONE:		888-729-1206

	MAIL ADDRESS:	
		STREET 1:		333 LUDLOW STREET
		STREET 2:		NORTH TOWER, 6TH FLOOR
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			06902

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Sema4 Holdings Corp.
		DATE OF NAME CHANGE:	20210721

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CM Life Sciences, Inc.
		DATE OF NAME CHANGE:	20200715

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Stueland Katherine
		CENTRAL INDEX KEY:			0001689575
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		458 BRANNAN STREET
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94107
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001689575</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001818331</issuerCik>
      <issuerName>GeneDx Holdings Corp.</issuerName>
      <secFileNumber>001-39482</secFileNumber>
      <issuerAddress>
        <com:street1>333 Ludlow St, North Tower</com:street1>
        <com:street2>6th Floor</com:street2>
        <com:city>Stamford</com:city>
        <com:stateOrCountry>CT</com:stateOrCountry>
        <com:zipCode>06902</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>888-729-1206</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Katherine Stueland</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Morgan Stanley Smith Barney</name>
        <address>
          <com:street1>2000 Westchester Avenue</com:street1>
          <com:city>Purchase</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10577-2530</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>2731</noOfUnitsSold>
      <aggregateMarketValue>258700</aggregateMarketValue>
      <noOfUnitsOutstanding>28244306</noOfUnitsOutstanding>
      <approxSaleDate>03/10/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <acquiredDate>03/10/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Restricted Stock Unit Vest</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2731</amountOfSecuritiesAcquired>
      <paymentDate>03/10/2025</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Katherine Stueland</name>
        <address>
          <com:street1>333 Ludlow St, North Tower</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <saleDate>12/16/2024</saleDate>
      <amountOfSecuritiesSold>10501</amountOfSecuritiesSold>
      <grossProceeds>806000</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Katherine Stueland</name>
        <address>
          <com:street1>333 Ludlow St, North Tower</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <saleDate>01/02/2025</saleDate>
      <amountOfSecuritiesSold>18006</amountOfSecuritiesSold>
      <grossProceeds>1407700</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Katherine Stueland</name>
        <address>
          <com:street1>333 Ludlow St, North Tower</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <saleDate>01/07/2025</saleDate>
      <amountOfSecuritiesSold>51420</amountOfSecuritiesSold>
      <grossProceeds>4858100</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Katherine Stueland</name>
        <address>
          <com:street1>333 Ludlow St, North Tower</com:street1>
          <com:street2>6th Floor</com:street2>
          <com:city>Stamford</com:city>
          <com:stateOrCountry>CT</com:stateOrCountry>
          <com:zipCode>06902</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <saleDate>01/29/2025</saleDate>
      <amountOfSecuritiesSold>1657</amountOfSecuritiesSold>
      <grossProceeds>130000</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>Represents 2,731 shares to be sold on behalf of the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units, and shares sold in the past 3 months by the Reporting Person, including: 1) 12,158 shares sold to cover tax withholding obligations in connection with the vesting and settlement of RSUs to satisfy tax withholding obligations to be funded by a sell to cover transaction; and 2) 69,426 shares in connection with sales pursuant to the Reporting Persons Rule 10b5-1 trading plan adopted on August 16, 2024.</remarks>
    <noticeSignature>
      <noticeDate>03/10/2025</noticeDate>
      <signature>/s/ Katherine Stueland</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
