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Selected Quarterly Financial Data (Unaudited) - Selected Quarterly Financial Data (Detail) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 12 Months Ended
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Dec. 31, 2017 | Sep. 30, 2017 | Jun. 30, 2017 | Mar. 31, 2017 | Dec. 31, 2016 | Sep. 30, 2016 | Jun. 30, 2016 | Mar. 31, 2016 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Quarterly Financial Information Disclosure [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  | $ 43,562 | [1] | $ 35,578 | [1] | $ 30,475 | [1] | $ 15,286 | [1] | $ 11,962 | [1] | $ 5,268 | [1] | $ 97 | [1] | $ 4 | [1] | $ 124,901 | [1] | $ 17,331 | [1] | $ 61
Gross profit | [2] | 41,107 |  | 33,443 |  | 28,251 |  | 13,023 |  | 10,258 |  | 4,423 |  | (429) |  |  |  | 115,824 |  | 14,252 |  |
Net loss |  | $ (68,871) |  | $ (65,248) |  | $ (67,441) |  | $ (87,843) |  | $ (78,696) |  | $ (71,613) |  | $ (71,322) |  | $ (49,762) |  | $ (289,403) |  | $ (271,393) |  | $ (164,443)
Basic and diluted net loss per share |  | $ (0.55) | [3] | $ (0.53) | [3] | $ (0.55) | [3] | $ (0.72) | [3] | $ (0.65) | [3] | $ (0.61) | [3] | $ (0.63) | [3] | $ (0.45) | [3] | $ (2.36) | [3] | $ (2.34) | [3] | $ (1.63)
[1] | The Company commenced commercial sales of NUPLAZID in May 2016. The quarters after March 31, 2016 reflect net product revenue related to NUPLAZID.
[2] | Determined by subtracting cost of product sales from product sales, net.
[3] | Net loss per common share, basic and diluted, are computed independently for each quarter and the full year based upon respective average shares outstanding. Therefore, the sum of the quarterly net loss per common share amounts may not equal the annual amounts reported.

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- Definition The amount of net income or loss for the period per each share in instances when basic and diluted earnings per share are the same amount and reported as a single line item on the face of the financial statements. Basic earnings per share is the amount of net income or loss for the period per each share of common stock or unit outstanding during the reporting period. Diluted earnings per share includes the amount of net income or loss for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period. + References No definition available. + Details
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