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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2017
Income Tax Disclosure [Abstract] |
Summary of Domestic and Foreign Pre-tax Income (Loss) | Domestic and foreign pre-tax income (loss) is as follows (in thousands):
|  | Years Ended December 31, |
|  | 2017 |  |  | 2016 |  |  | 2015 |
Domestic |  |  | (45,249 | ) |  | $ | (18,419 | ) |  | $ | 25,854 |
Foreign |  |  | (243,035 | ) |  |  | (251,633 | ) |  |  | (189,967 | )
|  |  | (288,284 | ) |  | $ | (270,052 | ) |  | $ | (164,113 | )
Components of Deferred Tax Assets | The components of the deferred tax assets are as follows (in thousands):
|  | December 31, |
|  | 2017 |  |  | 2016 |
NOL carryforwards |  | $ | 163,059 |  |  | $ | 168,753 |
R&D credit carryforwards |  |  | 27,862 |  |  |  | 21,016 |
Capitalized R&D |  |  | 5,606 |  |  |  | 3,977 |
Stock-based compensation |  |  | 30,986 |  |  |  | 27,576 |
Other |  |  | 10,110 |  |  |  | 6,102 |
|  |  | 237,623 |  |  |  | 227,424 |
Valuation allowance |  |  | (237,623 | ) |  |  | (227,424 | )
|  | $ | — |  |  | $ | — |
Reconciliation of Income Taxes to Amount Computed by Applying Statutory Federal Income Tax Rate to Pretax Loss | A reconciliation of income taxes to the amount computed by applying the statutory federal income tax rate to the pretax loss is summarized as follows (in thousands):
|  | Years Ended December 31, |
|  | 2017 |  |  | 2016 |  |  | 2015 |
Amounts computed at statutory federal rate |  | $ | (98,016 | ) |  | $ | (91,818 | ) |  | $ | (55,799 | )
Stock-based compensation and other permanent differences |  |  | 1,341 |  |  |  | 3,065 |  |  |  | 1,752 |
R&D credits |  |  | (5,573 | ) |  |  | (3,390 | ) |  |  | (3,782 | )
Change in valuation allowance |  |  | (28,230 | ) |  |  | 27,583 |  |  |  | 4,580 |
State taxes |  |  | (26 | ) |  |  | 272 |  |  |  | 742 |
Contingencies |  |  | 360 |  |  |  | 361 |  |  |  | 2,247 |
Foreign rate differential |  |  | 61,480 |  |  |  | 64,065 |  |  |  | 48,456 |
Tax Cuts and Jobs Act |  |  | 68,889 |  |  |  | — |  |  |  | — |
Other |  |  | 894 |  |  |  | 1,203 |  |  |  | 2,134 |
Income tax expense |  | $ | 1,119 |  |  | $ | 1,341 |  |  | $ | 330 |
Unrecognized Tax Benefits | The following table provides a reconciliation of changes in unrecognized tax benefits (in thousands):
|  | Years Ended December 31, |
|  | 2017 |  |  | 2016 |  |  | 2015 |
Balance at beginning of period |  | $ | 2,664 |  |  | $ | 2,301 |  |  | $ | — |
Additions related to current period tax positions |  |  | 361 |  |  |  | 363 |  |  |  | 2,301 |
Provisional impact of Tax Cuts and Jobs Act |  |  | (1,092 | ) |  |  | — |  |  |  | — |
Balance at end of period |  | $ | 1,933 |  |  | $ | 2,664 |  |  | $ | 2,301 |

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