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Commitments and Contingencies - Additional Information (Detail) - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Other Commitments [Line Items] |  |  |
Operating lease, expiration year | 2020-05 |  |
Rent expense | $ 3,800,000 | $ 2,800,000 | $ 2,900,000
Restricted cash | $ 2,475,000 | 2,375,000 |
Maximum |  |  |
Other Commitments [Line Items] |  |  |
Percentage of royalty payments obligation on net product sales | 2.00% |  |
Letter of Credit [Member] |  |  |
Other Commitments [Line Items] |  |  |
Restricted cash |  |  | $ 500,000
Letter of Credit [Member] | Corporate Credit Card Program |  |  |
Other Commitments [Line Items] |  |  |
Restricted cash |  | $ 2,000,000 |
Vehicles [Member] |  |  |
Other Commitments [Line Items] |  |  |
Operating leases arrangement term |  |  | 36 months

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