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Summary of Significant Accounting Policies (Tables) | 12 Months Ended
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Dec. 31, 2017
Accounting Policies [Abstract] |
Schedule of Estimated Useful Lives by Major Asset Category | Estimated useful lives by major asset category are as follows:
|  | Useful Lives
Machinery and equipment |  | 5 to 7 years
Computers and software |  | 3 years
Furniture and fixtures |  | 10 years
Weighted-Average Assumptions Used to Estimate Fair Value of Employee Stock Options | The estimated fair value of each stock option and purchase right is then expensed over the requisite service period, which is generally the vesting period. The following weighted-average assumptions were used during these periods:
|  | Years Ended December 31, |
|  | 2017 |  |  | 2016 |  |  | 2015 |
Stock Options: |  |  |  |  |  |  |  |  |  |  |  |
Expected volatility |  |  | 68 | % |  |  | 78 | % |  |  | 89 | %
Risk-free interest rate |  |  | 2 | % |  | 1-2 | % |  |  | 1-2 | %
Expected dividend yield |  |  | 0 | % |  |  | 0 | % |  |  | 0 | %
Expected life of options in years |  |  | 5.8 |  |  |  | 5.7 |  |  |  | 5.7 |
Weighted-Average Assumptions Used to Estimate Fair Value of Employee Stock Purchase Plan Rights |
|  | Years Ended December 31, |
|  | 2017 |  |  | 2016 |  |  | 2015 |
Employee Stock Purchase Plan: |  |  |  |  |  |  |  |  |  |  |  |
Expected volatility |  | 44%-62 | % |  | 60%-77 | % |  | 51%-59 | %
Risk-free interest rate |  | 1.0%-1.7 | % |  | 0.4%-1.0 | % |  | 0.1%-0.9 | %
Expected dividend yield |  |  | 0 | % |  |  | 0 | % |  |  | 0 | %
Expected life in years |  | 0.5-2.0 |  |  | 0.5-2.0 |  |  | 0.5-2.0 |
Summary of Stock-based Compensation Expense Included in Statements of Operations | The table below summarizes the total stock-based compensation expense included in the Company’s statements of operations for the periods presented (in thousands):
|  | Years Ended December 31, |
|  | 2017 |  |  | 2016 |  |  | 2015 |
Cost of product sales |  | $ | 3,690 |  |  | $ | 1,218 |  |  | $ | — |
Research and development |  |  | 26,485 |  |  |  | 18,050 |  |  |  | 12,171 |
Sales, general and administrative |  |  | 45,357 |  |  |  | 35,997 |  |  |  | 28,023 |
|  | $ | 75,532 |  |  | $ | 55,265 |  |  | $ | 40,194 |

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