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v3.8.0.1

Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Cash flows from operating activities |  |  |
Net loss | $ (289,403,000) | $ (271,393,000) | $ (164,443,000)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Stock-based compensation | 75,532,000 | 55,265,000 | 40,194,000
Amortization of premiums and accretion of discounts on investment securities | (291,000) | 89,000 | (2,060,000)
Amortization of intangible assets | 1,477,000 | 985,000 | 0
Depreciation | 1,236,000 | 843,000 | 647,000
Income tax benefit from exercise of stock options |  | (596,000) | (247,000)
Loss on disposal of assets | 4,000 | 5,000 |
Changes in operating assets and liabilities: |  |  |
Accounts receivable, net | (11,440,000) | (5,903,000) |
Interest and other receivables | 150,000 | 401,000 | (674,000)
Inventory | (1,012,000) | (3,305,000) |
Prepaid expenses and other current assets | (911,000) | (4,731,000) | (804,000)
Restricted cash | (100,000) | (2,000,000) | (375,000)
Other assets | 431,000 | (456,000) | (42,000)
Accounts payable | 4,874,000 | 2,240,000 | (344,000)
Accrued liabilities | 4,206,000 | 15,579,000 | 6,256,000
Deferred revenue | (2,644,000) | 2,644,000 |
Long-term liabilities | 34,000 | (75,000) | 97,000
Net cash used in operating activities | (217,857,000) | (210,408,000) | (121,795,000)
Cash flows from investing activities |  |  |
Purchases of investment securities | (478,818,000) | (683,355,000) | (269,486,000)
Maturities of investment securities | 572,103,000 | 430,937,000 | 419,197,000
Intangible assets |  | (8,000,000) |
Purchases of property and equipment | (812,000) | (1,506,000) | (2,141,000)
Net cash provided by (used in) investing activities | 92,473,000 | (261,924,000) | 147,570,000
Cash flows from financing activities |  |  |
Proceeds from issuance of common stock, net of issuance costs | 31,188,000 | 518,896,000 | 14,547,000
Proceeds from settlement agreement |  | 14,320,000 |
Deferred offering costs |  |  | (292,000)
Income tax benefit from exercise of stock options |  | 596,000 | 247,000
Net cash provided by financing activities | 31,188,000 | 533,812,000 | 14,502,000
Effect of exchange rate changes on cash | (6,000) | 2,000 | 7,000
Net (decrease) increase in cash and cash equivalents | (94,202,000) | 61,482,000 | 40,284,000
Cash and cash equivalents at beginning of period | 163,620,000 | 102,138,000 | 61,854,000
Cash and cash equivalents at end of period | 69,418,000 | 163,620,000 | 102,138,000
Supplemental disclosure of cash flow information: |  |  |
Cash paid for income taxes | 1,367,000 | 365,000 | 415,000
Supplemental disclosure of noncash information: |  |  |
Property and equipment purchases in accounts payable and accrued liabilities | 9,000 | 220,000 | $ 156,000
Stock-based compensation capitalized in inventory | $ (61,000) | $ 870,000 |

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- Definition The sum of the periodic adjustments of the differences between securities' face values and purchase prices that are charged against earnings. This is called accretion if the security was purchased at a discount and amortization if it was purchased at premium. As a noncash item, this element is an adjustment to net income when calculating cash provided by or used in operations using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585 + Details
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- Definition The cash outflow to acquire debt and equity securities not classified as either held-to-maturity securities or trading securities which would be classified as available-for-sale securities and reported at fair value, with unrealized gains and losses excluded from earnings and reported in a separate component of shareholders' equity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3213-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=82896770&loc=d3e26853-111562 + Details
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- Definition The cash outflow to acquire asset without physical form usually arising from contractual or other legal rights, excluding goodwill. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3213-108585 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3213-108585 + Details
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- Definition The cash inflow associated with the amount received by a corporation from a shareholder during the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3255-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with the sale or maturity (principal being due) of securities not classified as either held-to-maturity securities or trading securities which are classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=82896770&loc=d3e26853-111562 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585 + Details
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- References No definition available. + Details
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