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Summary of Significant Accounting Policies - Additional Information (Detail) | 1 Months Ended | 12 Months Ended |
--- | --- | --- | ---
Apr. 30, 2016 USD ($) | Dec. 31, 2017 USD ($) Customer Segment shares | Dec. 31, 2016 USD ($) Customer shares | Dec. 31, 2015 USD ($) shares | Mar. 31, 2017 USD ($)
Summary Of Significant Accounting Policy [Line Items] |  |  |  |  |
Accounts receivable written off |  | $ 0 | $ 0 | $ 0 |
Charge on finished goods inventory |  | 700,000 | 0 | 0 |
Impairment losses |  | 0 |  |  |
One-time contingent regulatory milestone payment pursuant to agreement with Ipsen Group | $ 8,000,000 |  |  |  |
Finite-lived intangible assets, net | $ 8,000,000 |  |  |  |
Amortization of intangible assets |  | 1,477,000 | 985,000 | 0 |
Estimated future amortization expense, 2018 |  | 1,500,000 |  |  |
Estimated future amortization expense, 2019 |  | 1,500,000 |  |  |
Estimated future amortization expense, 2020 |  | 1,500,000 |  |  |
Estimated future amortization expense, 2021 |  | 1,000,000 |  |  |
Advertising costs |  | 15,600,000 | 1,600,000 |  |
Advertising costs capitalized as prepaid expenses |  | $ 0 | $ 0 |  |
Number of large customers | Customer |  | 4 | 4 |  |
Stock compensation expense related to non-employee stock options |  | $ 75,532,000 | $ 55,265,000 | $ 40,194,000 |
Antidilutive securities to purchase common stock | shares |  | 18,526,000 | 14,739,000 | 11,525,000 |
Number of business segments | Segment |  | 1 |  |  |
ASU 2016-09 |  |  |  |  |
Summary Of Significant Accounting Policy [Line Items] |  |  |  |  |
Increase in deferred tax assets to record unrecognized excess tax benefits |  |  |  |  | $ 36,800,000
Increase to additional paid-in capital with corresponding increase to accumulated deficit |  |  |  |  | 300,000
Increase in deferred tax assets to record excess tax benefit |  |  |  |  | $ 100,000
Chief Executive Officer [Member] |  |  |  |  |
Summary Of Significant Accounting Policy [Line Items] |  |  |  |  |
Stock compensation expense related to non-employee stock options |  |  |  | $ 9,000,000 |
Customer Concentration Risk | Sales Revenue, Product Line | Four Customers |  |  |  |  |
Summary Of Significant Accounting Policy [Line Items] |  |  |  |  |
Concentration risk, percentage |  | 89.00% | 93.00% |  |
Customer Concentration Risk | Accounts Receivable | Four Customers |  |  |  |  |
Summary Of Significant Accounting Policy [Line Items] |  |  |  |  |
Concentration risk, percentage |  | 87.00% | 91.00% |  |

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