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Income Taxes - Components of Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016
--- | --- | ---
Income Tax Disclosure [Abstract] |  |
NOL carryforwards | $ 163,059 | $ 168,753
R&D credit carryforwards | 27,862 | 21,016
Capitalized R&D | 5,606 | 3,977
Stock-based compensation | 30,986 | 27,576
Other | 10,110 | 6,102
Deferred Tax Assets, Gross | 237,623 | 227,424
Valuation allowance | (237,623) | (227,424)
Deferred Tax Assets, Net | $ 0 | $ 0

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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible operating loss carryforwards. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 25 -Paragraph 20 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=96869850&loc=d3e28680-109314 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 6 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32621-109319 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32632-109319 + Details
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