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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2017

Income Tax Disclosure [Abstract]

Summary of Domestic and Foreign Pre-tax Income (Loss)

Domestic and foreign pre-tax income (loss) is as follows (in thousands):

		Years Ended December 31,
		2017				2016				2015
Domestic			(45,249	)		$	(18,419	)		$	25,854
Foreign			(243,035	)			(251,633	)			(189,967	)
			(288,284	)		$	(270,052	)		$	(164,113	)

Components of Deferred Tax Assets

The components of the deferred tax assets are as follows (in thousands):

		December 31,
		2017				2016
NOL carryforwards		$	163,059			$	168,753
R&D credit carryforwards			27,862				21,016
Capitalized R&D			5,606				3,977
Stock-based compensation			30,986				27,576
Other			10,110				6,102
			237,623				227,424
Valuation allowance			(237,623	)			(227,424	)
		$	—			$	—

Reconciliation of Income Taxes to Amount Computed by Applying Statutory Federal Income Tax Rate to Pretax Loss

A reconciliation of income taxes to the amount computed by applying the statutory federal income tax rate to the pretax loss is summarized as follows (in thousands):

		Years Ended December 31,
		2017				2016				2015
Amounts computed at statutory federal rate		$	(98,016	)		$	(91,818	)		$	(55,799	)
Stock-based compensation and other permanent differences			1,341				3,065				1,752
R&D credits			(5,573	)			(3,390	)			(3,782	)
Change in valuation allowance			(28,230	)			27,583				4,580
State taxes			(26	)			272				742
Contingencies			360				361				2,247
Foreign rate differential			61,480				64,065				48,456
Tax Cuts and Jobs Act			68,889				—				—
Other			894				1,203				2,134
Income tax expense		$	1,119			$	1,341			$	330

Unrecognized Tax Benefits

The following table provides a reconciliation of changes in unrecognized tax benefits (in thousands):

		Years Ended December 31,
		2017				2016				2015
Balance at beginning of period		$	2,664			$	2,301			$	—
Additions related to current period tax positions			361				363				2,301
Provisional impact of Tax Cuts and Jobs Act			(1,092	)			—				—
Balance at end of period		$	1,933			$	2,664			$	2,301

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

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Tabular disclosure of income before income tax between domestic and foreign jurisdictions.

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-Topic 235
-SubTopic 10
-Section S99
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Tabular disclosure of the change in unrecognized tax benefits.

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