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Income Taxes - Components of Deferred Tax Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2017	Dec. 31, 2016
Income Tax Disclosure [Abstract]
NOL carryforwards	$ 163,059	$ 168,753
R&D credit carryforwards	27,862	21,016
Capitalized R&D	5,606	3,977
Stock-based compensation	30,986	27,576
Other	10,110	6,102
Deferred Tax Assets, Gross	237,623	227,424
Valuation allowance	(237,623)	(227,424)
Deferred Tax Assets, Net	$ 0	$ 0

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards.

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