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Income Taxes - Reconciliation of Income Taxes to Amount Computed by Applying Statutory Federal Income Tax Rate to Pretax Loss (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Income Tax Disclosure [Abstract]
Amounts computed at statutory federal rate	$ (98,016)	$ (91,818)	$ (55,799)
Stock-based compensation and other permanent differences	1,341	3,065	1,752
R&D credits	(5,573)	(3,390)	(3,782)
Change in valuation allowance	(28,230)	27,583	4,580
State taxes	(26)	272	742
Contingencies	360	361	2,247
Foreign rate differential	61,480	64,065	48,456
Tax Cuts and Jobs Act	68,889
Other	894	1,203	2,134
Income tax expense	$ 1,119	$ 1,341	$ 330

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Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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