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Basis of Presentation and Significant Accounting Policies - Additional Information (Detail) - USD ($)
 1 Months Ended 3 Months Ended 6 Months Ended
May 31, 2018
Apr. 30, 2016
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Jan. 01, 2018
Dec. 31, 2017
Basis Of Presentation And Significant Accounting Policies [Line Items]                
Net cash used in operations         $ (86,111,000) $ (129,461,000)    
Net decrease in cash and cash equivalents         5,400,000 (19,731,000)    
Accounts receivable written off         0 0    
One-time contingent regulatory milestone payment pursuant to agreement with Ipsen Group   $ 8,000,000            
Finite-lived intangible assets, net   $ 8,000,000            
Amortization of intangible assets     $ 400,000 $ 400,000 738,000 738,000    
Estimated future amortization expense, remainder of 2018     700,000   700,000      
Estimated future amortization expense, 2019     1,500,000   1,500,000      
Estimated future amortization expense, 2020     1,500,000   1,500,000      
Estimated future amortization expense, 2021     1,000,000   1,000,000      
Aggregate carrying amount of strategic equity investment     2,900,000   2,900,000      
Loss on strategic investments     (200,000)   (247,000)      
Revenue recognition     (1,341,233,000)   (1,341,233,000)     $ (1,223,671,000)
Exclusivity Deed | Neuren                
Basis Of Presentation And Significant Accounting Policies [Line Items]                
Aggregate carrying amount of strategic equity investment $ 3,100,000              
Shares subscribed 1,330,000              
ASU 2016-18                
Basis Of Presentation And Significant Accounting Policies [Line Items]                
Net cash used in operations           100,000    
Net decrease in cash and cash equivalents           100,000    
Topic 606 [Member]                
Basis Of Presentation And Significant Accounting Policies [Line Items]                
Cumulative-effect adjustment to retained earnings             $ 0  
Topic 606 [Member] | Difference effect of change - higher (lower)                
Basis Of Presentation And Significant Accounting Policies [Line Items]                
Revenue recognition     $ 0   $ 0      
Selling, general and administrative expense                
Basis Of Presentation And Significant Accounting Policies [Line Items]                
Prior period reclassification adjustment       400,000   500,000    
Selling, general and administrative expense | Exclusivity Deed | Neuren                
Basis Of Presentation And Significant Accounting Policies [Line Items]                
Payments for exclusivity right $ 900,000              
Total operating expense                
Basis Of Presentation And Significant Accounting Policies [Line Items]                
Prior period reclassification adjustment       $ 400,000   $ 500,000