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Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Revenues
Type of Revenue [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember
Total revenues	$ 57,063	$ 30,475	$ 105,931	$ 45,761
Operating expenses
Type of Cost, Good or Service [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember
Cost of product sales	$ 3,562	$ 2,224	$ 5,715	$ 4,487
License fees and royalties	1,516	982	2,848	1,657
Research and development	46,592	34,180	85,868	69,589
Selling, general and administrative	69,472	61,125	130,398	126,785
Total operating expenses	121,142	98,511	224,829	202,518
Loss from operations	(64,079)	(68,036)	(118,898)	(156,757)
Interest income, net	1,279	993	2,449	1,956
Other expense	(247)		(247)
Loss before income taxes	(63,047)	(67,043)	(116,696)	(154,801)
Income tax expense	219	398	866	483
Net loss	$ (63,266)	$ (67,441)	$ (117,562)	$ (155,284)
Net loss per common share, basic and diluted	$ (0.51)	$ (0.55)	$ (0.94)	$ (1.27)
Weighted average common shares outstanding, basic and diluted	124,910	122,122	124,819	121,888

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