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License Agreements - Additional Information (Detail) - USD ($)	1 Months Ended		3 Months Ended	9 Months Ended
	Aug. 31, 2018	May 31, 2018	Sep. 30, 2018	Sep. 30, 2018
License Agreements [Line Items]
Loss on strategic investments				$ 1,967,000
Other assets
License Agreements [Line Items]
Aggregate carrying amount of strategic equity investment			$ 1,200,000	1,200,000
Other expense
License Agreements [Line Items]
Loss on strategic investments			1,700,000	2,000,000
Exclusivity Deed | Neuren
License Agreements [Line Items]
Aggregate carrying amount of strategic equity investment		$ 3,100,000
Shares subscribed		1,330,000
Exclusivity Deed | Neuren | Selling, general and administrative expense
License Agreements [Line Items]
Payments for exclusive right		$ 900,000
License Agreements | Neuren | North America
License Agreements [Line Items]
Upfront payment	$ 10,000,000
License Agreements | Neuren | North America | Maximum
License Agreements [Line Items]
Milestone payments payable	$ 455,000,000
License Agreements | Neuren | Research and development | North America
License Agreements [Line Items]
Upfront payment			$ 10,000,000	$ 10,000,000

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