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Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Revenues
Type of Revenue [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember
Total revenues	$ 58,305	$ 35,578	$ 164,236	$ 81,339
Operating expenses
Type of Cost, Good or Service [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember
Cost of product sales	$ 3,839	$ 2,135	$ 9,554	$ 6,622
License fees and royalties	1,536	1,078	4,384	2,735
Research and development	53,112	36,421	138,980	106,010
Selling, general and administrative	61,089	61,588	191,487	188,373
Total operating expenses	119,576	101,222	344,405	303,740
Loss from operations	(61,271)	(65,644)	(180,169)	(222,401)
Interest income, net	1,229	1,063	3,678	3,019
Other expense	(1,720)		(1,967)
Loss before income taxes	(61,762)	(64,581)	(178,458)	(219,382)
Income tax expense	376	667	1,242	1,150
Net loss	$ (62,138)	$ (65,248)	$ (179,700)	$ (220,532)
Net loss per common share, basic and diluted	$ (0.50)	$ (0.53)	$ (1.44)	$ (1.81)
Weighted average common shares outstanding, basic and diluted	125,009	122,484	124,883	122,089

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