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Commitments and Contingencies - Additional Information (Detail) | 1 Months Ended | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | ---
Aug. 31, 2018 USD ($) | May 31, 2018 USD ($) shares | Dec. 31, 2018 USD ($) ft² | Dec. 31, 2018 USD ($) ft² | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Dec. 31, 2015 USD ($)
Other Commitments [Line Items] |  |  |  |  |  |  |
Operating lease, expiration year |  |  |  | 2031-02 |  |  |
Rent expense |  |  |  | $ 4,500,000 | $ 3,800,000 | $ 2,800,000 |
Restricted cash |  |  | $ 4,826,000 | 4,826,000 | $ 2,475,000 | 2,375,000 | $ 375,000
Loss on strategic investment |  |  |  | 1,840,000 |  |  |
Other assets |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Aggregate carrying amount of strategic equity investment |  |  | $ 1,300,000 | 1,300,000 |  |  |
Other expense |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Loss on strategic investment |  |  |  | 1,800,000 |  |  |
Exclusivity Deed | Neuren |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Aggregate carrying amount of strategic equity investment |  | $ 3,100,000 |  |  |  |  |
Shares subscribed | shares |  | 1,330,000 |  |  |  |  |
Exclusivity Deed | Neuren | Sales, general and administrative |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Payments for exclusive right |  | $ 900,000 |  |  |  |  |
North America | License Agreements | Neuren |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Upfront payment | $ 10,000,000 |  |  |  |  |  |
North America | License Agreements | Neuren | Research and development |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Upfront payment |  |  |  | 10,000,000 |  |  |
Corporate Office Space Lease Agreement |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Rent expense |  |  |  | $ 0 |  |  |
Operating leases arrangement term |  |  | 10 years 9 months | 10 years 9 months |  |  |
Operating leases commencement year |  |  | 2020-05 |  |  |  |
Operating leases renewal term |  |  |  | two additional five year periods |  |  |
Corporate Office Space Lease Agreement | California |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Office space leases in square feet | ft² |  |  | 67,020 | 67,020 |  |  |
Maximum |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Percentage of royalty payments obligation on net product sales |  |  |  | 2.00% |  |  |
Maximum | North America | License Agreements | Neuren |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Milestone payments payable | $ 455,000,000 |  |  |  |  |  |
Letter of Credit |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Restricted cash |  |  |  |  |  |  | $ 400,000
Letter of Credit | Corporate Credit Card Program |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Restricted cash |  |  |  |  |  | $ 2,000,000 |
Letter of Credit | Corporate Office Space Lease Agreement |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Restricted cash |  |  | $ 2,200,000 | $ 2,200,000 |  |  |
Vehicles [Member] |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Operating leases arrangement term |  |  |  |  |  |  | 36 months
Vehicles [Member] | Minimum |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Operating leases arrangement term |  |  |  |  |  |  | 12 months
Vehicles [Member] | Maximum |  |  |  |  |  |  |
Other Commitments [Line Items] |  |  |  |  |  |  |
Operating leases arrangement term |  |  |  |  |  |  | 50 months

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