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Summary of Significant Accounting Policies - Summary of Stock-based Compensation Expense Included in Statements of Operations (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |
Stock-based compensation expense | $ 81,564 | $ 75,532 | $ 55,265
Cost of product sales |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |
Stock-based compensation expense | 3,863 | 3,690 | 1,218
Research and development |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |
Stock-based compensation expense | 32,038 | 26,485 | 18,050
Sales, general and administrative |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |
Stock-based compensation expense | $ 45,663 | $ 45,357 | $ 35,997

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