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Income Taxes - Components of Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2018 | Dec. 31, 2017
--- | --- | ---
Income Tax Disclosure [Abstract] |  |
NOL carryforwards | $ 170,476 | $ 163,059
R&D credit carryforwards | 32,984 | 27,862
Capitalized R&D | 7,421 | 5,606
Stock-based compensation | 45,492 | 30,986
Other | 14,750 | 10,110
Deferred Tax Assets, Gross | 271,123 | 237,623
Valuation allowance | $ (271,123) | (237,623)
Deferred Tax Assets, Net |  | $ 0

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