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Summary of Significant Accounting Policies (Tables) | 12 Months Ended
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Dec. 31, 2018
Accounting Policies [Abstract] |
Schedule of Reconciliation of Cash, Cash Equivalents and Restricted Cash | The following table provides a reconciliation of cash, cash equivalents and restricted cash reported in the consolidated balance sheets that sum to the total of the same such amounts shown in the Consolidated Statements of Cash Flows (in thousands).
|  | Twelve Months Ended December 31, 2018 |  |  | Twelve Months Ended December 31, 2017 |  |  | Twelve Months Ended December 31, 2016 |
|  | Beginning of period |  |  | End of period |  |  | Beginning of period |  |  | End of period |  |  | Beginning of period |  |  | End of period |
Cash and cash equivalents |  | $ | 69,418 |  |  | $ | 134,758 |  |  | $ | 163,620 |  |  | $ | 69,418 |  |  | $ | 102,138 |  |  | $ | 163,620 |
Restricted cash |  |  | 2,475 |  |  |  | 4,826 |  |  |  | 2,375 |  |  |  | 2,475 |  |  |  | 375 |  |  |  | 2,375 |
Total cash, cash equivalents and restricted cash shown in the statements of cash flows |  | $ | 71,893 |  |  | $ | 139,584 |  |  | $ | 165,995 |  |  | $ | 71,893 |  |  | $ | 102,513 |  |  | $ | 165,995 |
Schedule of Estimated Useful Lives by Major Asset Category | Estimated useful lives by major asset category are as follows:
|  | Useful Lives
Machinery and equipment |  | 5 to 7 years
Computers and software |  | 3 years
Furniture and fixtures |  | 10 years
Weighted-Average Assumptions Used to Estimate Fair Value of Employee Stock Options | The estimated fair value of each stock option and purchase right is then expensed over the requisite service period, which is generally the vesting period. The following weighted-average assumptions were used during these periods:
|  | Years Ended December 31, |
|  | 2018 |  |  | 2017 |  |  | 2016 |
Stock Options: |  |  |  |  |  |  |  |  |  |  |  |
Expected volatility |  |  | 71 | % |  |  | 68 | % |  |  | 78 | %
Risk-free interest rate |  |  | 3 | % |  |  | 2 | % |  | 1-2% |
Expected dividend yield |  |  | 0 | % |  |  | 0 | % |  |  | 0 | %
Expected life of options in years |  |  | 5.7 |  |  |  | 5.8 |  |  |  | 5.7 |
Weighted-Average Assumptions Used to Estimate Fair Value of Employee Stock Purchase Plan Rights |
|  | Years Ended December 31, |
|  | 2018 |  |  | 2017 |  |  | 2016 |
Employee Stock Purchase Plan: |  |  |  |  |  |  |  |  |  |  |  |
Expected volatility |  | 59%-79% |  |  | 44%-62% |  |  | 60%-77% |
Risk-free interest rate |  | 2.1%-2.8% |  |  | 1.0%-1.7% |  |  | 0.4%-1.0% |
Expected dividend yield |  |  | 0 | % |  |  | 0 | % |  |  | 0 | %
Expected life in years |  | 0.5-2.0 |  |  | 0.5-2.0 |  |  | 0.5-2.0 |
Summary of Stock-based Compensation Expense Included in Statements of Operations | The table below summarizes the total stock-based compensation expense included in the Company’s statements of operations for the periods presented (in thousands):
|  | Years Ended December 31, |
|  | 2018 |  |  | 2017 |  |  | 2016 |
Cost of product sales |  | $ | 3,863 |  |  | $ | 3,690 |  |  | $ | 1,218 |
Research and development |  |  | 32,038 |  |  |  | 26,485 |  |  |  | 18,050 |
Sales, general and administrative |  |  | 45,663 |  |  |  | 45,357 |  |  |  | 35,997 |
|  | $ | 81,564 |  |  | $ | 75,532 |  |  | $ | 55,265 |

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