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Summary of Significant Accounting Policies - Additional Information (Detail) | 1 Months Ended | 12 Months Ended |
--- | --- | --- | ---
Apr. 30, 2016 USD ($) | Dec. 31, 2018 USD ($) Customer Segment shares | Dec. 31, 2017 USD ($) Customer shares | Dec. 31, 2016 USD ($) Customer shares | Jan. 01, 2018 USD ($)
Summary Of Significant Accounting Policy [Line Items] |  |  |  |  |
Net cash used in operations |  | $ (167,470,000) | $ (217,757,000) | $ (208,408,000) |
Net decrease in cash and cash equivalents |  | 67,691,000 | (94,102,000) | 63,482,000 |
Accounts receivable written off |  | 100,000 | 0 | 0 |
Charge on finished goods inventory |  | 2,700,000 | 700,000 | 0 |
Impairment losses |  | 0 |  |  |
One-time contingent regulatory milestone payment pursuant to agreement with Ipsen Group | $ 8,000,000 |  |  |  |
Finite-lived intangible assets, net | $ 8,000,000 |  |  |  |
Amortization of intangible assets |  | 1,476,000 | 1,477,000 | 985,000 |
Estimated future amortization expense, 2019 |  | 1,500,000 |  |  |
Estimated future amortization expense, 2020 |  | 1,500,000 |  |  |
Estimated future amortization expense, 2021 |  | 1,000,000 |  |  |
Advertising costs |  | 39,800,000 | 15,600,000 | $ 1,600,000 |
Advertising costs capitalized as prepaid expenses |  | 0 | 0 |  |
Revenue recognition |  | $ (1,468,863,000) | $ (1,223,671,000) |  |
Number of large customers | Customer |  | 4 | 4 | 4 |
Antidilutive securities to purchase common stock | shares |  | 20,824,000 | 18,526,000 | 14,739,000 |
Number of business segments | Segment |  | 1 |  |  |
Tax rate |  | 21.00% | 35.00% |  |
Customer Concentration Risk | Sales Revenue, Product Line | Four Customers |  |  |  |  |
Summary Of Significant Accounting Policy [Line Items] |  |  |  |  |
Concentration risk, percentage |  | 85.00% | 89.00% | 93.00% |
Customer Concentration Risk | Accounts Receivable | Four Customers |  |  |  |  |
Summary Of Significant Accounting Policy [Line Items] |  |  |  |  |
Concentration risk, percentage |  | 84.00% | 87.00% | 91.00% |
ASU 2016-18 |  |  |  |  |
Summary Of Significant Accounting Policy [Line Items] |  |  |  |  |
Net cash used in operations |  |  | $ (100,000) |  |
Net decrease in cash and cash equivalents |  |  | $ (100,000) |  |
Topic 606 |  |  |  |  |
Summary Of Significant Accounting Policy [Line Items] |  |  |  |  |
Cumulative-effect adjustment to retained earnings |  |  |  |  | $ 0
Increase to additional paid-in capital with corresponding increase to accumulated deficit |  |  |  |  | $ 0
Topic 606 | Difference effect of change - higher (lower) |  |  |  |  |
Summary Of Significant Accounting Policy [Line Items] |  |  |  |  |
Revenue recognition |  | $ 0 |  |  |
ASU 2016-09 |  |  |  |  |
Summary Of Significant Accounting Policy [Line Items] |  |  |  |  |
Cumulative-effect adjustment to retained earnings |  | 300,000 |  |  |
Increase in deferred tax assets to record unrecognized excess tax benefits |  | 36,800,000 |  |  |
Increase to additional paid-in capital with corresponding increase to accumulated deficit |  | 300,000 |  |  |
Increase in deferred tax assets to record excess tax benefit |  | 100,000 |  |  |
ASU 2016-02 |  |  |  |  |
Summary Of Significant Accounting Policy [Line Items] |  |  |  |  |
Expected right-to-use asset upon ASU adoption |  | 12,000,000 |  |  |
Expected lease liability upon ASU adoption |  | $ 12,000,000 |  |  |

X
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